氧化应激因子FOXO在大气细颗粒物致肺遗传损伤中的作用及机制

91643108
2016
H3007.卫生毒理
张荣
重大研究计划
教授
河北医科大学
90万元
毒作用机制;呼吸系统;氧化应激;大气细颗粒物;遗传毒性
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice 期刊论文 Linpeng Niu;Mengjiao Shao;Yuan Liu;Jinfeng Hu;Ruofan Li;Heran Xie;Lixiao Zhou;Lei Shi;Rong Zhang;Yujie Niu
2 Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a 期刊论文 Lixiao Zhou;Peiyuan Li;Mengyue Zhang;Bin Han;Chen Chu;Xuan Su;Binghua Li;Hui Kang;Jie Ning;Boyuan Zhang;Shitao Ma;Dong Su;Yaxian Pang;Yujie Niu;Rong Zhang
3 Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice 期刊论文 Xuan Su;Junzhi Tian;Binghua Li;Lixiao Zhou;Hui Kang;Zijie Pei;Mengyue Zhang;Chen Li;Mengqi Wu;Qian Wang;Bin Han;Chen Chu;Yaxian Pang;Jie Ning;Boyuan Zhang;Yujie Niu;Rong Zhang
4 Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation 期刊论文 Chen Chu;Haiya Zhang;Shijie Cui;Bin Han;Lixiao Zhou;Ning Zhang;Xuan Su;Yujie Niu;Wen Chen;Rui Chen;Rong Zhang;Yuxin Zheng
5 PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse 期刊论文 Zhou Lixiao;Su Xuan;Li Binghua;Chu Chen;Sun Hongyue;Zhang Ning;Han Bin;Li Chen;Zou Bingjie;Niu Yujie;Zhang Rong
6 PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome in mouseNALP3 会议论文 张荣
7 Increased risk of carotid atherosclerosis for long-term exposure to indoor coal-burning pollution in rural area, Hebei Province, China 期刊论文 Yaxian Pang;Boyuan Zhang;Dongmei Xing;Jinmei Shang;Fengge Chen;Hui Kang;Chen Chu;Binghua Li;Juan Wang;Lixiao Zhou;Xuan Su;Bin Han;Jie Ning;Peiyuan Li;Shitao Ma;Dong Su;Rong Zhang;Yujie Niu
8 N(6)-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats. 期刊论文 Han Bin;Chu Chen;Su Xuan;Zhang Ning;Zhou Lixiao;Zhang Mengyue;Yang Shuaishuai;Shi Lei;Zhao Bo;Niu Yujie;Zhang Rong
9 miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5 期刊论文 Jie Ning;Peiyuan Li;Boyuan Zhang;Bin Han;Xuan Su;Qian Wang;Xiurong Wang;Binghua Li;Hui Kang;Lixiao Zhou;Chen Chu;Ning Zhang;Yaxian Pang;Yujie Niu;Rong Zhang
10 The Effects of Nrf2/NLRP3 Signaling Pathway Modulating Inflammation on Depression Induced by Ambient PM2.5 会议论文 张荣
11 Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects. 期刊论文 Chu Chen;Zhou Lixiao;Xie Heran;Pei Zijie;Zhang Mengyue;Wu Mengqi;Zhang Shaohui;Wang Luqi;Zhao Chunfang;Shi Lei;Zhang Ning;Niu Yujie;Zheng Yuxin;Zhang Rong
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