KLF4与组蛋白修饰酶协同调控血管平滑肌细胞特异基因表达的分子机制

31671182
2016
C1101.循环与血液生理
温进坤
面上项目
教授
河北医科大学
61万元
血管平滑肌细胞;转录因子KLF4;基因表达;血管稳态;组蛋白修饰
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Inhibition of KLF5-Myo9b-RhoA pathway-mediated podosome formation in macrophages ameliorates abdominal aortic aneurysm 期刊论文 Ma D;Zheng B;Suzuki T;Zhang R;Jiang C;Bai D;Yin W;Yang Z;Zhang X;Hou L;Zhan H;Wen JK
2 Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells 期刊论文 Qin Y;Zheng B;Yang GS;Yang HJ;Zhou J;Yang Z;Zhang XH;Zhao HY;Shi JH;Wen JK
3 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation 期刊论文 Ma D;Zhang RN;Wen Y;Yin WN;Bai D;Zheng GY;Li JS;Zheng B;Wen JK
4 iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration 期刊论文 Zhang ML;Zheng B;Tong F;Yang Z;Wang ZB;Yang BM;Sun Y;Zhang XH;Zhao YL;Wen JK
5 A novel regulatory mechanism of smooth muscle α-actin expression by NRG-1/circACTA2/miR-548f-5p axis 期刊论文 Sun Y;Yang Z;Zheng B;Zhang XH;Zhang ML;Zhao XS;Zhao HY;Suzuki T;Wen JK
6 Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development 期刊论文 Zheng B;Zheng CY;Zhang Y;Yin WN;Li YH;Liu C;Zhang XH;Nie CJ;Zhang H;Wen J;Liu SF;Wen JK
7 Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression 期刊论文 Zhao XS;Zheng B;Wen Y;Sun Y;Wen JK;Zhang XH
8 Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis 期刊论文 Yang GS;Zheng B;Qin Y;Zhou J;Yang Z;Zhang XH;Zhao HY;Yang HJ;Wen JK
9 Oxidative stress induces neuronal apoptosis through suppressing transcription factor EB phosphorylation at Ser467 期刊论文 Su Q;Zheng B;Wang CY;Yang YZ;Luo WW;Ma SM;Zhang XH;Ma D;Sun Y;Yang Z;Wen JK;Liu ZX
10 Tanshinone ⅡA inhibits VSMC inflammation and proliferation in vivo and in vitro by downregulating miR-712-5p expression 期刊论文 Qin Y;Zheng B;Yang GS;Zhou J;Yang HJ;Nie ZY;Wang TR;Zhang XH;Zhao HY;Shi JH;Wen JK
11 Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose 期刊论文 Zhou J;Zhang L;Zheng B;Zhang L;Qin Y;Zhang X;Yang Z;Nie Z;Yang G;Yu J;Wen JK
12 中医脉络学说构建及其指导微血管病变防治 奖励 吴以领;杨跃进;贾振华;李新立;黄从新;杨明会;曹克将;董强;吴伟康;曾定尹;温进坤;高彦彬;周京敏;魏聪;郑青山
13 Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission 期刊论文 Ma D;Zheng B;Liu HL;Zhao YB;Liu X;Zhang XH;Li Q;Shi WB;Suzuki T;Wen JK
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