基于肿瘤转移模型的多功能拓扑异构酶抑制剂的设计、合成及抗侵袭转移研究

21571153
2015
B0702.生物分子的化学生物学
李长正
面上项目
教授
新乡医学院
60万元
拓扑异构酶抑制剂;肿瘤转移;抗肿瘤机制;多功能药物;金属配合物
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Antitumor Activity of a Novel Dual Functional Podophyllotoxin Derivative Involved PI3K/AKT/mTOR Pathway 期刊论文 yongli Li;tengfei huang;yunFu;tingting wang;tiesuo zhao;sheng guo;yanjie sun;yun yang;changzheng Li
2 Copper Ion Attenuated the Antiproliferative Activityof Di-2-pyridylhydrazone DithiocarbamateDerivative; However, There Was a Lack ofCorrelation between ROS Generation andAntiproliferative Activity 期刊论文 tingting wang;yun fu;tengfei huang;youxun liu;meihao wu;李长正
3 Calcium release induced by 2-pyridinecarboxaldehydethiosemicarbazone and its copper complexcontributes to tumor cell death 期刊论文 yun fu;youxun liu;jiangang wang;cuiping li;sufeng zhou;yunyang;pingxin zhou;chengbiao lu;李长正
4 The antiproliferative activity of di-2-pyridylketone dithiocarbamate is partly attributed to catalase inhibition: detailing the interaction by spectroscopic methods 期刊论文 cuiping li;youxun liu;yun fu;tengfei huang;lixia kang;changzheng Li
5 The novel dithiocarbamate, DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2- ERK 1/2 signaling 期刊论文 Yun Yang;Youxun Liu;Rui Guo;Yun Fu;Ziheng Zhang;Pengfei Zhang;Pingxin Zhou;Tingting Wang;Tengfei Huang;Xiaotong Li;Changzheng Li
6 一种多功能鬼旧毒素衍生物及其制备方法和应用 专利 李长正;黄腾飞;康丽霞;付云;李翠萍;王婷婷;孙颜杰
7 二硫代甲酸衍生物及其制备方法和应用 专利 李长正;黄腾飞;李翠萍;刘友勋;付云;周素凤;王婷婷
8 Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult 期刊论文 Zhangyang Qi;Meihao Wu;Yun Fu;Tengfei Huang;Tingting Wang;Yanjie Sun;Zhibo Feng;Changzheng Li
9 Synergistic anti-tumor activity of Nimotuzumab in combination with Trastuzumab in HER2-positive breast cancer 期刊论文 YunYang;Rui Guo;Xiaoting Tian;Ziheng Zhang;Pengfei Zhang;Changzheng Li;Zhiwei Feng
10 Antiproliferative activity of di-2-pyridylhydrazonedithiocarbamate acetate partly involved in p53mediated apoptosis and autophagy 期刊论文 Tingting Wang;Youxun Liu;Yun Fu;Tengfei Huang;Yun Yang;Shaoshan Li;Changzheng Li
11 p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in Ptox(Dpt)-Induced EMT Inhibition in Liver Cancer Cell Lines 期刊论文 Li Yongli;Wang Tingting;Sun Yanjie;Huang Tengfei;Li Cuiping;Fu Yun;Li Yichun;Li Changzheng
12 Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation 期刊论文 Tengfei Huang;Yanjie Sun;Yongli Li;Tingting Wang;Yun Fu;Cuiping Li;Changzheng Li
13 Di-2-pyridylhydrazone Dithiocarbamate Butyric Acid Ester Exerted Its Proliferative Inhibition against Gastric Cell via ROS-Mediated Apoptosis and Autophagy 期刊论文 Xingshuang Guo;Yun Fu;Zhuo Wang;Tingting Wang;Cuiping Li;Tengfei Huang;Fulian Gao;Changzheng Li
14 The Synthesis of a Coumarin CarbohydrazideDinuclear Copper Complex BasedFluorescence Probe and Its Detection ofThiols 期刊论文 Guangjie He;Jing Li;Lu Yang;Chunhua Hou;Tianjun Ni;Zhijun Yang;Xinlai Qian;Changzheng Li
15 DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway 期刊论文 Wang Zhuo;Li Cuiping;Li Yongli;Guo Xingshuang;Yan Zhaoyu;Gao Fulian;Li Changzheng
16 Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA 期刊论文 Sun Yanjie;Li Cuiping;Feng Jiankang;Li Yongli;Zhai Xinbo;Zhang Lei;Li Changzheng
17 Analysis of the Interaction of Dp44mT with HumanSerum Albumin and Calf Thymus DNA UsingMolecular Docking and Spectroscopic Techniques 期刊论文 zhongjie xu;youxun liu;sufeng zhou;yun fu;李长正
18 吡啶腙二硫代甲酸衍生物及其制备方法和应用 专利 李长正;李勇莉;王婷婷;张煜;刘友勋;付云;周素凤;黄腾飞
19 Interaction of Di-2-pyridylketone 2-pyridineCarboxylic Acid Hydrazone and Its Copper Complexwith BSA: Effect on Antitumor Activity as Revealedby Spectroscopic Studies 期刊论文 Cuiping LI;Tengfei Huang;Yun Fu;Youxun Liu;Sufeng Zhou;Zhangyang Qi;Changzheng Li
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