ILC2细胞新亚群对肠癌发生发展的调控作用及功能机制研究
92042302
2020
H1101.免疫系统发育与分化异常
范祖森
重大研究计划
研究员
中国科学院生物物理研究所
150万元
转分化;ILC2-C;肿瘤发生;ILC2-A;肠癌
2021-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine | 期刊论文 | Zhen Xiong;Xiaoxiao Zhu;Jingjing Geng;Yuwei Xu;Runyuan Wu;Cunzhen Li;Dongdong Fan;Xiwen Qin;Ying Du;Yong Tian;Zusen Fan |
| 2 | Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription | 期刊论文 | Nian Liu;Jiacheng He;Dongdong Fan;Yang Gu;Jianyi Wang;Huimu Li;Xiaoxiao Zhu;Ying Du;Yong Tian;Benyu Liu;Zusen Fan |
| 3 | Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA | 期刊论文 | Liu Benyu;Liu Nian;Zhu Xiaoxiao;Yang Liuliu;Ye Buqing;Li Huimu;Zhu Pingping;Lu Tiankun;Tian Yong;Fan Zusen |
| 4 | Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling | 期刊论文 | Yang Gu;Yanying Wang;Luyun He;Jiahang Zhang;Xiaoxiao Zhu;Nian Liu;Jianyi Wang;Tiankun Lu;Lei He;Yong Tian;Zusen Fan |
| 5 | Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity | 期刊论文 | Buqing Ye;Liuliu Yang;Benyu Liu;Nian Liu;Dongdong Fan;Huimu Li;Lei Sun;Ying Du;Shuo Wang;Yong Tian;Zusen Fan |
| 6 | N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism | 期刊论文 | Yanying Wang;Jing Wang;Xiaoyu Li;Xushen Xiong;Jianyi Wang;Ziheng Zhou;Xiaoxiao Zhu;Yang Gu;Dan Dominissini;Lei He;Yong Tian;Chengqi Yi;Zusen Fan |
| 7 | Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations | 期刊论文 | Zhenzhen Chen;Jiayi Wu;Benyu Liu;Guangtan Zhang;Zhiwei Wang;Lulu Zhang;Kaili Wang;Zusen Fan;Pingping Zhu |
| 8 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons | 期刊论文 | Zhu Pingping;Lu Tiankun;Wu Jiayi;Fan Dongdong;Liu Benyu;Zhu Xiaoxiao;Guo Hui;Du Ying;Liu Feng;Tian Yong;Fan Zusen |
| 9 | Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF | 期刊论文 | Zhenzhen Chen;Tiankun Lu;Lan Huang;Zhiwei Wang;Zhongyi Yan;Yubo Guan;Wenjing Hu;Zusen Fan;Pingping Zhu |
| 10 | 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis | 期刊论文 | Pingping Zhu;Tiankun Lu;Zhenzhen Chen;Benyu Liu;Dongdong Fan;Chong Li;Jiayi Wu;Luyun He;Xiaoxiao Zhu;Ying Du;Yong Tian;Zusen Fan |
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