遗传性耳聋伴固醇代谢异常新型小型猪动物模型的建立与应用
81771000
2017
H1404.听觉异常与平衡障碍
曹新
面上项目
教授
南京医科大学
80万元
听力;动物模型;内耳
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种耳聋模型猪的重构卵及其构建方法,耳聋模型猪、构建方法及其应用 | 专利 | 曹新;姚俊;曾华沙;杨海元;王盈;邢光前;陈智斌;魏钦俊;鲁雅洁;戴一凡 |
| 2 | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis | 期刊论文 | Wang Tianming;Wei Qinjun;Liang Lihong;Tang Xujun;Yao Jun;Lu Yajie;Qu Yuan;Chen Zhibin;Xing Guangqian;Cao Xin |
| 3 | Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues | 期刊论文 | Shi Hairong;Wang Hongshun;Yao Jun;Lin Changsong;Wei Qinjun;Lu Yajie;Cao Xin |
| 4 | OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway | 期刊论文 | Zhang Cui;Zhang Hongdu;Zhang Min;Lin Changsong;Wang Hongshun;Yao Jun;Wei Qinjun;Lu Yajie;Chen Zhibin;Xing Guangqian;Cao Xin |
| 5 | Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling | 期刊论文 | Hairong Shi;Hongshun Wang;Cheng Zhang;Yajie Lu;Jun Yao;Zhibing Chen;Guangqian Xing;Qinjun Wei;Xin Cao |
| 6 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia | 期刊论文 | Yao Jun;Zeng Huasha;Zhang Min;Wei Qinjun;Wang Ying;Yang Haiyuan;Lu Yajie;Li Rongfeng;Xiong Qiang;Zhang Lining;Chen Zhibin;Xing Guangqian;Cao Xin;Dai Yifan |
| 7 | OSBPL2基因缺陷型巴马小型猪肥胖相关特征的分析 | 期刊论文 | 王天明;曾华沙;王盈;杨海元;姚俊;鲁雅洁;魏钦俊;曹新;戴一凡 |
| 8 | Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to beta-catenin | 期刊论文 | Tianming Wang;Tianyu Zhang;Youzhi Tang;Hongshun Wang;Qinjun Wei;Yajie Lu;Jun Yao;Yuan Qu;Xin Cao |
| 9 | Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity | 期刊论文 | Wang Hongshun;Lin Changsong;Yao Jun;Shi Hairong;Zhang Cui;Wei Qinjun;Lu Yajie;Chen Zhibin;Xing Guangqian;Cao Xin |
| 10 | 人/猪OSBPL2同源性比较及猪PFFs靶基因敲除细胞系的建立. | 期刊论文 | 曾华沙;姚俊;王红顺;王盈;杨海元;曹新;戴一凡 |
| 11 | 25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway | 期刊论文 | Wang Quan;Lin Changsong;Zhang Cui;Wang Hongshun;Lu Yajie;Yao Jun;Wei Qinjun;Xing Guangqian;Cao Xin |
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