MAPK通路通过磷酸化代谢性核受体（PXR/CAR）介导羧酸酯酶的负性调节作用研究
81673513
2016
H3511.临床药理
刘娓
面上项目
副教授
南京医科大学
54万元
羧酸酯酶;药物代谢酶;孕烷X受体;MAPK;通路;组成型雄甾烷受体
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXR alpha and Suppresses the Expression of PXR, CAR and Their Target Genes | 期刊论文 | Ning Rui;Zhan Yunran;He Shuangcheng;Hu Jinhua;Zhu Zhu;Hu Gang;Yan Bingfang;Yang Jian;Liu Wei |
| 2 | Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways | 期刊论文 | Minjie Zhang;Jiaxi Qu;Zhiwei Gao;Qi Qi;Hong Yin;Ling Zhu;Yichen Wu;Wei Liu;Jian Yang;Xuefeng Huang |
| 3 | 17 beta-estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes | 期刊论文 | Wu Lili;Hafiz Muhammad Zubair;Guan Yu;He Shuangcheng;Xiong Jing;Liu Wei;Yan Bingfang;Li Xiaoping;Yang Jian |
| 4 | New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III | 期刊论文 | Zhao Yun-Fang;Zhang Yu-Wei;Wang Yinru;Morris-Natschke Susan L.;Liu Wei;Shang Ting-Ting;Yin Hong;Lee Kuo-Hsiung;Huang Xue-Feng |
| 5 | Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives | 期刊论文 | Chen Zhong;Duan Huaqing;Tong Xiaohang;Hsu Peiling;Han Li;Morris Natschke Susan L;Yang Shilin;Liu Wei;Lee Kuo Hsiung |
| 6 | Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, 2 Cytotoxicity, and Mechanism of Action | 期刊论文 | Hong Yin;Min-Jie Zhang;Ren-Feng An;Jing Zhou;Wei Liu;Susan L. Morris-Natschke;Yung-Yi Cheng;Kuo-Hsiung Lee;Xue-Feng Huang |
| 7 | Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3 pathway | 期刊论文 | Zhu Zhu;Wang Yu-Wen;Ge Ding-Hao;Lu Ming;Liu Wei;Xiong Jing;Hu Gang;Li Xiao-Ping;Yang Jian |
| 8 | Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root | 期刊论文 | Wang Yin Ru;Yu Yun;Li Shu Ming;Liu Wei;Li Wei B.;Morris Natschke Susan L;Goto Masuo;Lee Kuo Hsiung;Huang Xue Feng |
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