TIGAR信号调控失衡介导的脑微血管紧密连接蛋白损伤参与痴呆分子机制研究
81673415
2016
H3501.神经精神药物药理
卢应梅
面上项目
教授
南京医科大学
54万元
低血糖;紧密连接蛋白;中隔野/海马神经环路;TIGAR;痴呆症
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation. | 期刊论文 | Gong DM;Zhang YL;Chen DY;Hong LJ;Han F;Liu QB;Jiang JJ;Lu YM |
| 2 | Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis | 期刊论文 | Liu Xiuxiu;Yang Lin;Shao Lingxiao;He Yang;Wu Gang;Bao Yuhuan;Lu Nannan;Gong Dongmei;Lu Yaping;Cui Tiantian;Sun Ninghe;Chen Danyang;Shi Weixing;Fukunaga Kohji;Chen Hongshan;Chen Zhong;Han Feng;Lu Yingmei |
| 3 | Role of pericyte-derived SENP1 in neuronal injury after brain ischemia | 期刊论文 | Sun M;Chen X;Yin YX;Gao Y;Zhang L;Chen B;Ji Y;Fukunaga K;Han F;Lu YM |
| 4 | 脑卒中防治的药物新靶点及新策略 | 奖励 | 陈忠;韩峰;盛荣;胡薇薇;张翔南;卢应梅;韩蓉 |
| 5 | Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4 | 期刊论文 | Tan Chao;Lu Nannan;Wang Chengkun;Chen Danyang;Sun Ninghe;Lyu Hang;Körbelin Jakob;Shi Weixing;Fukunaga Kohji;Lu Yingmei;Han Feng |
| 6 | 一类检测甲醛的荧光探针及其制备和应用 | 专利 | 李新;韩益丰;梁星光;卢应梅;韩峰 |
| 7 | 轴突导向因子重组蛋白Semaphorin3G的医药用途 | 专利 | 韩峰;陆楠楠;谭超;卢应梅;孙宁赫;陈丹阳;林雯;费烨;王成坤;蒋权 |
| 8 | 一种检测蛋白质巯基亚硝基化的荧光探针及其制备和应用 | 专利 | 李新;邵世怡;韩峰;卢应梅;胡永洲 |
| 9 | Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. | 期刊论文 | Shao Lingxiao;Jiang Quan;Liu Xiuxiu;Gong Danyang;Yin Yixuan;Wu Gang;Sun Ninghe;Wang Chengkun;Chen Qiaozhen;Yu Chao;Shi Weixing;Fan Hengyu;Fukunaga Kohji;Chen Zhong;Lu Yingmei;Han Feng |
| 10 | Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator (TIGAR). | 期刊论文 | Wang CK;Ahmed MM;Jiang Q;Lu NN;Tan C;Gao YP;Mahmood Q;Chen DY;Fukunaga K;Li M;Chen Z;Wilcox CS;Lu YM;Qin ZH;Han F |
| 11 | GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury | 期刊论文 | Chen Danyang;Sun Ninghe;Lu Yaping;Hong Lingjuan;Cui Tiantian;Wang Chengkun;Chen Xinghui;Wang Shuaishuai;Feng Lili;Shi Weixing;Fukunaga Kohji;Chen Zhong;Lu Yingmei;Han Feng |
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