NCOA3在多发性骨髓瘤耐药性产生中的作用机制及其特异性抑制剂SI-2的应用研究
81870161
2018
H0811.骨髓瘤与浆细胞疾病
刘志强
面上项目
教授
天津医科大学
57万元
染色质重构;特异性抑制剂;多发性骨髓瘤;核受体共激活因子3;肿瘤耐药性
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | DKK1 suppresses WWP2 to enhance bortezomib resistance in multiple myeloma via regulating GLI2 ubiquitination | 期刊论文 | Qiguo Zhang;Wenyu Gong;Hongyan Wu;Jing Wang;Qichuan Jin;Chun Lin;Shiyun Xu;Wenqiang Bao;Yin Wang;Jing Wu;Shanshan Feng;Changzhi Zhao;Bing Chen;Zhiqiang Liu |
| 2 | Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2-mediated chromatin remodelling | 期刊论文 | Ying Xie;Na Han;Feng Li;Lijuan Wang;Gerui Liu;Meilin Hu;Sheng Wang;Xuelei Wei;Jing Guo;Hongmei Jiang;Jingjing Wang;Xin Li;Yixuan Wang;Jingya Wang;Xiyun Bian;Zhongjiao Zhu;Hui Zhang;Chunhua Liu;Xiaozhi Liu;Zhiqiang Liu |
| 3 | DKK1 activates noncanonical NF-kappaB signaling via IL-6-induced CKAP4 receptor in multiple myeloma | 期刊论文 | Xin Li;Jingjing Wang;Shuai Zhu;Jinxin Zheng;Ying Xie;Hongmei Jiang;Jing Guo;Yixuan Wang;Ziyi Peng;Mengqi Wang;Jingya Wang;Sheng Wang;Yuping Zhong;Zhiqiang Liu |
| 4 | Leptin correlates with monocytes activation and severe condition in COVID-19 patients | 期刊论文 | Jingya Wang;Yinyin Xu;Xiaoli Zhang;Sheng Wang;Ziyi Peng;Jing Guo;Hongmei Jiang;Jing Liu;Ying Xie;Jingjing Wang;Xin Li;Juan Liao;Chao Wan;Lihua Yu;Jinsong Hu;Beizhong Liu;Zhiqiang Liu |
| 5 | Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma | 期刊论文 | Jing Guo;Yangyang Lv;Sheng Wang;Ziyi Peng;Ying Xie;Yixuan Wang;Hongmei Jiang;Xin Li;Mengqi Wang;Meilin Hu;Jiangpeng Mu;Jingya Wang;Yangyang Xie;Xiankui Cheng;Zhigang Zhao;Zhiqiang Liu |
| 6 | Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma | 期刊论文 | Jing Liu;Ying Xie;Jing Guo;Xin Li;Jingjing Wang;Hongmei Jiang;Ziyi Peng;Jingya Wang;Sheng Wang;Qian Li;Linquan Ye;Yuping Zhong;Qiguo Zhang;Xiaozhi Liu;David M Lonard;Jin Wang;Bert W O'Malley;Zhiqiang Liu |
| 7 | Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation | 期刊论文 | Jingjing Wang;Xu Zhu;Lin Dang;Hongmei Jiang;Ying Xie;Xin Li;Jing Guo;Yixuan Wang;Ziyi Peng;Mengqi Wang;Jingya Wang;Sheng Wang;Qian Li;Yafei Wang;Qiang Wang;Lingqun Ye;Lirong Zhang;Zhiqiang Liu |
| 8 | Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma | 期刊论文 | Hongmei Jiang;Yixuan Wang;Jingjing Wang;Yafei Wang;Sheng Wang;Enyang He;Jing Guo;Ying Xie;Jingya Wang;Xin Li;Ziyi Peng;Mengqi Wang;Jian Hou;Zhiqiang Liu |
| 9 | Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma | 期刊论文 | Yinyin Xu;Jing Guo;Jing Liu;Ying Xie;Xin Li;Hongmei Jiang;Jingjing Wang;Ziyi Peng;Jingya Wang;Sheng Wang;Chao Wan;Lanting Chen;Yuping Zhong;Beizhong Liu;Zhiqiang Liu |
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