lncRNA-HELF通过调控肝星状细胞和巨噬细胞活化及交互作用促进肝纤维化的机制研究
81800542
2018
H0310.肝损伤、修复与再生
章坤
青年科学基金项目
副教授
天津医科大学
22万元
长链非编码RNA;肝纤维化;肝巨噬细胞;基因表达;肝星状细胞
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis | 期刊论文 | Zhang Kun;Shi Zhemin;Zhang Mengxia;Dong Xueyi;Zheng Lina;Li Guantong;Han Xiaohui;Yao Zhi;Han Tao;Hong Wei |
| 2 | ZINC62678696在制备抑制肝纤维化药物的用途 | 专利 | 洪伟;韩涛;章坤;姚庆斌;洪宇桁;韩晓辉;时哲敏;郑丽娜;胡志梅 |
| 3 | Transcriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells. | 期刊论文 | Shi Z;Zhang K;Chen T;Zhang Y;Du X;Zhao Y;Shao S;Zheng L;Han T;Hong W |
| 4 | A Transcriptome-Level Study Identifies Changing Expression Profiles for Ossification of the Ligamentum Flavum of the Spine. | 期刊论文 | Han Yawei;Hong Yuheng;Li Liandong;Li Tengshuai;Zhang Zhen;Wang Jingzhao;Xia Han;Tang Yutao;Shi Zhemin;Han Xiaohui;Chen Ting;Liu Qi;Zhang Mengxia;Zhang Kun;Hong Wei;Xue Yuan |
| 5 | 慢性炎症性疾病进展关键环节标志物及治疗靶标的筛选 | 奖励 | 洪伟;韩涛;章坤;郑丽娜;时哲敏 |
| 6 | HOTAIRM1 promotes osteogenic differentiation and alleviates osteoclast differentiation by inactivating the NF-κB pathway. | 期刊论文 | Ren Yi;Zhang Kun;Wang Jingzhao;Meng Xiaoxiang;Du Xiaoxiao;Shi Zhemin;Xue Yuan;Hong Wei |
| 7 | FFAR1-and FFAR4-dependent activation of Hippo pathway mediates DHA-induced apoptosis of androgen-independent prostate cancer cells. | 期刊论文 | Wang Jingzhao;Hong Yuheng;Shao Shuai;Zhang Kun;Hong Wei |
| 8 | The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition | 期刊论文 | Zhang Kun;Zhang Mengxia;Yao Qingbin;Han Xiaohui;Zhao Yanmian;Zheng Lina;Li Guantong;Liu Qi;Chang Yanan;Zhang Peijun;Cui Hongmei;Shi Zhemin;Chen Ting;Yao Zhi;Han Tao;Hong Wei |
| 9 | Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch. | 期刊论文 | Zhang Zhen;Qi Haixia;Xia Han;Liu Qi;Ren Yi;Zhang Kun;Xue Yuan;Hong Wei |
| 10 | SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker | 期刊论文 | Zhang Kun;Han Yawei;Hu Zhimei;Zhang Zhen;Shao Shuai;Yao Qingbin;Zheng Lina;Wang Jingzhao;Han Xiaohui;Zhang Yu;Chen Ting;Yao Zhi;Han Tao;Hong Wei |
| 11 | miR-342-3p promotes osteogenic differentiation via targeting ATF3. | 期刊论文 | Han Yawei;Zhang Kun;Hong Yuheng;Wang Jingzhao;Liu Qi;Zhang Zhen;Xia Han;Tang Yutao;Li Tengshuai;Li Liandong;Xue Yuan;Hong Wei |
| 12 | Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma. | 期刊论文 | Yu Zhenjun;Zhang Yu;Shao Shuai;Liu Qi;Li Yuhan;Du Xiaoxiao;Zhang Kun;Zhang Mengxia;Yuan Haixia;Yuan Qiang;Liu Tong;Gao Yingtang;Wang Yijun;Hong Wei;Han Tao |
| 13 | LncRNA Meg8 suppresses activation of hepatic stellate cells and epithelial-mesenchymal transition of hepatocytes via the Notch pathway. | 期刊论文 | Chen Ting;Lin Huajiang;Chen Xun;Li Guantong;Zhao Yanmian;Zheng Lina;Shi Zhemin;Zhang Kun;Hong Wei;Han Tao |
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