EPC源性外泌体传递miRNA对糖尿病视网膜病变血管保护作用及机制研究

81700846
2017
H1305.视网膜、脉络膜及玻璃体相关疾病
张惟
青年科学基金项目
副主任医师
天津医科大学
20万元
内皮祖细胞;血管保护;糖尿病视网膜病变;外泌体;内皮功能损伤
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1 期刊论文 Zhang Wei;Wang Yang;Kong Yichun
2 Pathogenic roles of microvesicles in diabetic retinopathy 期刊论文 Zhang Wei;Chen Song;Liu Ming-Lin
3 Mesenchymal stem cells-derived exosomes ameliorate blue light stimulation in retinal pigment epithelium cells and retinal laser injury by VEGF-dependent mechanism. 期刊论文 He Guang-Hui;Zhang Wei;Ma Ying-Xue;Yang Jing;Chen Li;Song Jian;Chen Song
4 Exosomes derived from platelet-rich plasma activate YAP and promote the fibrogenic activity of Müller cells via the PI3K/Akt pathway 期刊论文 Zhang Wei;Jiang Hao;Kong Yichun
5 人脐带间充质干细胞源性微囊泡对高糖诱导下大鼠视网膜神经节细胞损伤的保护作用及机制 期刊论文 梁泽玉;陈松;张惟;何广辉;王俊华;高翔;武斌
6 Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway 期刊论文 Wei Zhang;Xue Dong;Tian Wang;Yichun Kong
7 Transfection with CXCR4 potentiates homing of mesenchymal stem cells in vitro and therapy of diabetic retinopathy in vivo 期刊论文 Wang Jian;Zhang Wei;He Guang-Hui;Wu Bin;Chen Song
8 YAP is essential for TGF-β-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of Müller cells. 期刊论文 Zhang Wei;Kong Yichun
9 Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1 期刊论文 Zhang Wei;Song Jian;Zhang Yue;Ma Yingxue;Yang Jing;He Guanghui;Chen Song
10 阿托伐他汀对体外培养的大鼠骨髓间充质干细胞CXC趋化因子受体4表达及迁移能力的影响 期刊论文 武斌;陈松;张惟;何广辉;王健
11 Photo-Oxidative Blue-Light Stimulation in Retinal Pigment Epithelium Cells Promotes Exosome Secretion and Increases the Activity of the NLRP3 Inflammasome 期刊论文 Zhang Wei;Ma Yingxue;Zhang Yue;Yang Jing;He Guanghui;Chen Song
12 天津市科技进步一等奖 奖励 颜华;于金国;张惟;毛春洁;范玲玲;汪洋;江枫;陈庆中;李家男;王颖;胡艳滨;周琰倢
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