铁与Alpha-突触核蛋白相互作用共同参与帕金森病的细胞分子机制

81430024
2014
H0912.神经退行性变及相关疾病
谢俊霞
重点项目
教授
青岛大学
320万元
血红素加氧酶;神经保护;α-突触核蛋白;帕金森病;脑铁代谢
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Brain Iron Metabolism Dysfunction in Parkinson's Disease. 期刊论文 Hong Jiang;Jun Wang;Jack Rogers;Junxia Xie
2 Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin. 期刊论文 Xiaojun Yu;Ning Song;Xinli Guo;Hong Jiang;Haoyun Zhang;Junxia Xie
3 High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein. 期刊论文 Fengju Jia;Ning Song;Weiwei Wang;Xixun Du;Yajing Chi;Hong Jiang
4 Neuroprotective Effects of Brain-Gut Peptides: A Potential Therapy for Parkinson's Disease. 期刊论文 Dong Dong;Junxia Xie;Jun Wang
5 The effects of 6-hydroxydopamine on iron metabolism in astrocytes are mediated by hypoxic-inducible factor-2α. 会议论文 谢俊霞
6 Ferroptosis-Suppressor-Protein 1: a potential neuroprotective target for combating ferroptosis. 期刊论文 Leilei Chen; Junxia Xie
7 The association between CYP46A1 rs4900442 polymorphism and the risk of Alzheimer's disease: A meta-analysis. 期刊论文 Fengjv Jia;Zhiguo Liu;Ning Song;Xixun Du;Junxia Xie;Hong Jiang
8 Neuroprotective effect of resveratrol on rotenone-treated C57BL/6 mice. 期刊论文 Xiaofei Zhao;Jun Wang;Song Hu;Renping Wang;Yongjun Mao;Junxia Xie
9 The modulation of ghrelin on A-type potassium channels on substantia nigra dopaminergic neurons and its mechanism. 会议论文 谢俊霞
10 Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson's Disease Models. 期刊论文 Mingxia Bi;Qian Jiao;Xixun Du;Hong Jiang
11 Exogenous α-synuclein induce endoplasmic reticulum stress in primary cultured ventral mesencephalic astrocytes. 会议论文 谢俊霞
12 Ghrelin and Neurodegenerative Disorders-a Review. 期刊论文 Limin Shi;Xixun Du;Hong Jiang;Junxia Xie
13 Post translational of iron regulatory proteins on alpha-synuclein in SH-SY5Y cells. 会议论文 谢俊霞
14 Identification of neuronal autophagy regulators: Combined use of iKAP and THANATOS. 期刊论文 Leilei Chen;Junxia Xie
15 Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP+-induced toxicity in MES23.5 cells. 期刊论文 Mingchun Jiang;Xiaohan Chen;Xia Zhao;XuejieZhang;WenfangChen
16 The association between the C282Y and H63D polymorphisms of HFE gene and the risk of Parkinson’s disease: A meta-analysis. 期刊论文 Jianjian Xia;Huamin Xu;Hong Jiang;Junxia Xie
17 Ghrelin protects MES23.5 cells against rotenone via inhibiting mitochondrial dysfunction and apoptosis. 期刊论文 Jianhan Yu;Huamin Xu;Xiaoli Shen;Hong Jiang
18 Differential regulation of estrogen in iron metabolism in astrocytes and neurons. 期刊论文 Manman Xu;Xu Tan;Na Li;Hao Wu;Yue Wang;Junxia Xie;Jun Wang
19 外泌体及其在神经退行性疾病发生、发展和诊治中的作用 期刊论文 张鲁琳;刘明欣;谢俊霞;宋宁
20 The role of NMDA receptor in the iron accumulation of 6-OHDA-treated MES23.5 dopaminergic cells. 会议论文 谢俊霞
21 Interactions between iron and α-synuclein pathology in Parkinson's disease. 期刊论文 Bingbing Chen;Xiaoming Wen;Hong Jiang;Jun Wang;Ning Song;Junxia Xie
22 Activation of NMDA receptors mediated iron accumulation via modulating iron transporters in Parkinson's disease. 期刊论文 Huamin Xu;Xiaodong Liu;Jianjian Xia;Tianshu Yu;Yanan Qu;Hong Jiang;Junxia Xie
23 Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson’s disease: involvement of PI3K/Akt and MEK/ERK signaling pathways. 期刊论文 Wenfang Chen;Lin Wu;Zhongrui Du;Lei Chen;Aili Xu;Xiaohan Chen;Jijun Teng;Mansau Wong
24 Iron-induced oxidative stress contributes to α-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2. 期刊论文 Ranran Wang;Youcui Wang;Le Qu;Bingbing Chen;Hong Jiang;Ning Song;Junxia Xie
25 New insights into the crosstalk between NMDARs and iron: implications for understanding pathology of neurological diseases. 期刊论文 Huamin Xu;Hong Jiang;Junxia Xie
26 《帕金森病多巴胺能神经元退行性改变的分子机制及防治策略研究》 奖励 谢俊霞;姜宏;石丽敏;王俊;于晓俊
27 Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin. 会议论文 谢俊霞
28 Rosmarinic acid protectes SK-N-SH cells by inhibiting iron induced α-synuclein aggregation. 会议论文 谢俊霞
29 The neurological effects of ghrelin in brain diseases: Beyond metabolic functions. 期刊论文 Qian Jiao;Xixun Du;Yong Li;Bing Gong;Limin Shi;Tingting Tang;Hong Jiang
30 Hypoxia-inducible factors regulation on iron metabolism in 6-OHDA treated astrocytes. 会议论文 谢俊霞
31 Effect of estrogen on iron metabolism in mammals. 期刊论文 Xiao Yang;Manman Xu;Jun Wang;Junxia Xie
32 Regulation of iron metabolism by hypoxia-inducible factors. 期刊论文 Manman Xu;Jun Wang;Junxia Xie
33 Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells. 期刊论文 Zhen Tan;Huamin Xu;Xiaoli Shen;Hong Jiang
34 The protective effect of lactoferrin on ventral mesencephalon neurons against MPP(+) is not connected with its iron binding ability. 期刊论文 Jun Wang;Mingxia Bi;Huiying Liu;Ning Song;Junxia Xie
35 强化国家、省重点学科(实验室)建设:创新硕博士研究生培养模式的研究与实践 奖励 谢俊霞;陈蕾;陈文芳;姜宏;马泽刚;周宇;王俊;宋宁;徐华敏;谢安木
36 Dopamine in Parkinson's Disease: Precise Supplementation with Motor Planning. 期刊论文 Leilei Chen;Junxia Xie
37 GBA突变与帕金森病的研究进展 期刊论文 王冬霞;谢俊霞;宋宁
38 Iron Dysregulation in Parkinson's Disease: Focused on the Autophagy-Lysosome Pathway. 期刊论文 Leilei Chen;Yujv Huang;Juntao Cui;Ning Song;Junxia Xie
39 Iron, dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease. 期刊论文 Ning Song;Junxia Xie
40 Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease. 期刊论文 Xiaoyan Chen;Bao Xue;Jun Wang;Haixia Liu;Limin Shi;Junxia Xie
41 Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease. 期刊论文 Yong Li;Qian Jiao;Huamin Xu;Xixun Du;Limin Shi;Fengju Jia;Hong Jiang
42 Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. 期刊论文 Xianchang Sun;Xiaofan Ren;Lei Chen;Xianqi Gao;Junxia Xie;Wenfang Chen
43 Astroglial and microglial contributions to iron metabolism disturbance in Parkinson's disease. 期刊论文 Ning Song;Jun Wang;Hong Jiang;Junxia Xie
44 《电压依赖型钾通道在帕金森病中的调制作用研究》 奖励 谢俊霞
45 Ginsenoside Rg1 exerts anti-inflammatory effects via G protein-coupled estrogen receptor in LPS-induced microglia activation. 期刊论文 Xianqi Gao;Zhongrui Du;Liangjie Yuan;Wendi Zhang;Lei Chen;Jijun Teng;Mansau Wong;Junxia Xie;Wenfang Chen
46 Acute action of rotenone on excitability of catecholaminergic neurons in rostral ventrolateral medulla. 期刊论文 Zhaoqiang Zhang;Limin Shi;Xixun Du;Qian Jiao;Hong Jiang
47 Preferential Heme Oxygenase-1 Activation in Striatal Astrocytes Antagonizes Dopaminergic Neuron Degeneration in MPTP-Intoxicated Mice. 期刊论文 Xiaofeng Xu;Ning Song;Ranran Wang;Hong Jiang;Junxia Xie
48 Nesfatin-1 protects dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the C-Raf-ERK1/2-dependent anti-apoptotic pathway. 期刊论文 Xiaoli Shen;Ning Song;Xixun Du;Yong Li;Junxia Xie;Hong Jiang
49 Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model. 期刊论文 Weiwei Wang;Ning Song;Fengjv Jia;Tingting Tang;Weiqi Bao;Chuantao Zuo;Junxia Xie;Hong Jiang
50 胶质细胞在帕金森病神经元铁聚集及退变中的作用 期刊论文 徐华敏;王俊;宋宁;姜宏;谢俊霞
51 Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro. 期刊论文 Xixun Du;Huamin Xu;Limin Shi;Zhifeng Jiang;Ning Song;Hong Jiang;Junxia Xie
52 Protective effects and mechanisms of rosmarinic acid against rotenone-induced Parkinson’s disease models. 会议论文 谢俊霞
53 Investigation of behavioral dysfunctions induced by monoamine depletions in a mouse model of Parkinson's disease. 期刊论文 Yong Li;Qian Jiao;Xixun Du;Mingxia Bi;Shuaishuai Han;Lingling Jiao;Hong Jiang
54 《Identification of Neuronal Autophagy Regulators with iKAP and THANATOS》 奖励 谢俊霞
55 Protective effects of rosmarinic acid against iron-induced neurotoxicity in SK-N-SH cells. 会议论文 谢俊霞
56 New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson's Disease. 期刊论文 Huamin Xu;Youcui Wang;Ning Song;Jun Wang;Hong Jiang;Junxia Xie
57 The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease. 期刊论文 Haixia Liu;Lu Jia;Xiaoyan Chen;Limin Shi;Junxia Xie
58 Protective effects of Ndfip1 on MPP+-induced apoptosis in MES23.5 cells and its underlying mechanisms. 期刊论文 Kai Liu;Huamin Xu;Hengwei Xiang;Peng Sun;Junxia Xie
59 Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats. 期刊论文 Jun Wang;Mingxia Bi;Junxia Xie
60 Ghrelin reduces A-type potassium channels in nigral dopaminergic neurons via PKC but not PKA pathway. 会议论文 谢俊霞
61 帕金森病中铁与Alpha-突触核蛋白的相互作用 期刊论文 王俊;宋宁;徐华敏;姜宏;谢俊霞
62 《帕金森病脑铁重新分布的分子机制与多巴胺能神经元损伤的干预策略》 奖励 谢俊霞;姜宏;石丽敏;王俊;马泽刚
63 Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation. 期刊论文 Le Qu;Huamin Xu;Wenting Jia;Hong Jiang;Junxia Xie
64 Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells. 期刊论文 Qian Jiao;Xixun Du;Jie Wei;Yong Li;Hong Jiang
65 The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in 6-OHDA rat model of Parkinson’s disease. 会议论文 谢俊霞
66 《In silico Kinome Activity Profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy》 奖励 谢俊霞
67 《原代星形胶质细胞/原代中脑腹侧神经元共培养体系在铁代谢中的应用》 专利 谢俊霞;王俊;许曼曼
68 Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1. 期刊论文 Wenting Jia;Huamin Xu;Xixun Du;Hong Jiang;Junxia Xie
69 G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia. 期刊论文 Zhongrui Du;Xiaoqing Feng;Na Li;Jiang-Xue Qu;Lu Feng;Lei Chen;Wenfang Chen
70 Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. 期刊论文 Shida Zhou;Xinxing Du;Junxia Xie;Jun Wang
71 Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases. 期刊论文 Lei Chen;Rong Xu;Fengjiao Sun;Yan Xue;Xiaomeng Hao;Hongxia Liu;Hua Wang;Xinyi Chen;Ziran Liu;Wenshuai Deng;Xiaohua Han;Junxia Xie;Wingho Yung
72 The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in 6-OHDA rat model of Parkinson’s disease. 会议论文 谢俊霞
73 Preferential HO-1 activation in striatal astrocytes antagonized dopaminergic neurons degeneration in MPTP-intoxicated mice. 会议论文 谢俊霞
74 《缺氧诱导因子-2α作为作用靶点在帕金森病预防/治疗中的应用》 专利 谢俊霞;王俊;许曼曼
75 Assessments of plasma ghrelin levels in the early stages of parkinson's disease. 期刊论文 Ning Song;Weiwei Wang;Fengjv Jia;Xixun Du;Anmu Xie;Qing He;Xiaoli Shen;Jing Zhang;Jack T. Rogers;Junxia Xie;Hong Jiang
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