内质网蛋白TM6SF2在脂质代谢及非酒精性脂肪性肝病中的作用及机制研究

31770837
2017
C0509.生物学过程与代谢
辛永宁
面上项目
主任医师
青岛大学
60万元
脂质代谢;脂肪肝;内质网应激;TM6SF2;基因多态性
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population 期刊论文 Yingyu Xu;Zhenzhen Zhao;Shousheng Liu;Yingpu Xiao;Mengyuan Miao;Quanjiang Dong;Yongning Xin
2 Association Between Four ABCA1 gene Polymorphisms and Risk of Non-Alcoholic Fatty Liver Disease in a Chinese Han Population 期刊论文 Cong Wang;Shousheng Liu;Linlin Lu;Songling Liao;Haiyan Yue;Quanjiang Dong;Yongning Xin;Shiying Xuan
3 Transmission and clinical characteristics of asymptomatic patients with SARS-CoV-2 infection 期刊论文 Tan Jie;Liu Shousheng;Zhuang Likun;Chen Lizhen;Dong Mengzhen;Zhang Jie;Xin Yongning
4 MBOAT7 rs641738单核苷酸多态性与非酒精性脂肪性肝病的相关性 期刊论文 廖宋龄;刘守胜;王聪;陈立震;辛永宁;宣世英
5 Association of LDLR rs1433099 with the Risk of NAFLD and CVD in Chinese Han Population 期刊论文 Yongshuo Zhang;Shousheng Liu;Guangxia Chen;Linlin Cao;Yi Han;Yongning Xin
6 TM6SF2 E167K Variant Overexpression Promotes Expression of Inflammatory Cytokines in the HCC Cell Line HEPA 1-6 期刊论文 Shuixian Du;Songling Liao;Shousheng Liu;Yongning Xin
7 肝脏TM6SF2特异性敲除促进非酒精性脂肪性肝病小鼠肝脏脂肪变性 期刊论文 张杰;马学峰;王艺奋;王孟轲;庄立琨;刘守胜;辛永宁
8 KCNJ11 rs5210位点多态性与非酒精性脂肪性肝病及冠心病的遗传易感性分析 期刊论文 徐艳艳;赵真真;刘守胜;宋欢;辛永宁
9 Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population 期刊论文 Yuan Li;Shousheng Liu;Yuqiang Gao;Huan Ma;Shuhui Zhan;Yan Yang;Yongning Xin;Shiying Xuan
10 青岛地区汉族人群PNPLA3 rs738409单核苷酸多态性与冠心病的相关性 期刊论文 苗梦媛;刘守胜;赵真真;徐颖誉;辛永宁;宣世英
11 Combining I148M and E167K variants to improve risk prediction for nonalcoholic fatty liver disease in Qingdao Han population, China 期刊论文 Chen Lizhen;Ding Hongyun;Liu Shousheng;Liu Qun;Jiang Xiangjun;Xin Yongning;Xuan Shiying
12 The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis 期刊论文 Xuefeng Ma;Mengzhen Dong;Shousheng Liu;Jian Zhang;Zhenzhen Zhao;Jie Tan;Jie Zhang;Yongning Xin
13 Systematic Review and Meta-analysis of Circulating Fetuin-A Levels in Nonalcoholic Fatty Liver Disease 期刊论文 Shousheng Liu;Yifen Wang;Zhenzhen Zhao;Jianhan Xiao;Mengke Wang;Yongning Xin
14 Diagnostic value of MRI-PDFF for hepatic steatosis in patients with non-alcoholic fatty liver disease: a meta-analysis 期刊论文 Gu Jiulian;Liu Shousheng;Du Shuixian;Zhang Qing;Xiao Jianhan;Dong Quanjiang;Xin Yongning
15 Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway 期刊论文 Linlin Lu;Shousheng Liu;Quangjiang Dong;Yongning Xin
16 Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD 期刊论文 Jie Zhang;Jie Tan;Mengke Wang;Yifen Wang;Mengzhen Dong;Xuefeng Ma;Baokai Sun;Shousheng Liu;Zhenzhen Zhao;Lizhen Chen;Kai Liu;Yongning Xin;Likun Zhuang
17 Can elevated concentrations of ALT and AST predict the risk of ‘recurrence’ of COVID-19? 期刊论文 Chen Lizhen;Lin Zhonghua;Chen Juan;Liu Shousheng;Shi Te;Xin Yongning
18 基于遗传易感基因的NAFLD诊断标志物开发与临床应用 奖励 辛永宁;陈立震;刘守胜;杜水仙;张旸
19 Independent and joint correlation of PNPLA3 I148M and TM6SF2 E167K variants with the risk of coronary heart disease in patients with non-alcoholic fatty liver disease 期刊论文 Wu Jianting;Liu Shousheng;Xie Xiangjun;Liu Qun;Xin Yongning;Xuan Shiying
20 The clinical characteristics of pediatric inpatients with SARS‐CoV‐2 infection: a meta‐analysis and systematic review 期刊论文 Xuefeng Ma;Shousheng Liu;Lizhen Chen;Likun Zhuang;Jie Zhang;Yongning Xin
21 TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of nonalcoholic fatty liver disease in Chinese Han population 期刊论文 Qun Liu;Feng Xue;Jing Meng;Shousheng Liu;Lizhen Chen;Hui Gao;Ning Geng;Wenwen Jin;Yongning Xin;Shiying Xuan
22 MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line 期刊论文 Zhang Qing;Ma Xuefeng;Dong Mengzhen;Tan Jie;Zhang Jie;Zhuang Likun;Liu Shousheng;Xin Yongning
23 PNPLA3与TM6SF2等基因多态性在非酒精性脂肪性肝病风险预测及诊断中的应用 奖励 辛永宁;陈立震;刘守胜;耿宁;杜水仙;金文文
24 Association between Serum Cytokeratin-18 Neoepitope M30 (CK-18 M30) Levels and Chronic Hepatitis B: A Meta-Analysis 期刊论文 Changfei Li;Shousheng Liu;Linlin Lu;Quanjiang Dong;Shiying Xuan;Yongning Xin
25 基于APRI的慢性肝脏疾病非侵入性诊断标志物的临床应用研究 奖励 辛永宁;陈立震;刘守胜;林中华;金文文;杜水仙;耿宁
26 瘦素和脂联素在非酒精性脂肪性肝病合并冠心病患者血清中的表达及意义 期刊论文 徐振;刘守胜;谭杰;孙宝凯;杜水仙;辛永宁;宣世英
27 应用CRISPR/Cas9技术构建跨膜蛋白超家族6成员2 E167K基因敲入小鼠模型 期刊论文 孙宝凯;刘守胜;张杰;宣世英;辛永宁
28 Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis 期刊论文 Xuefeng Ma;Shousheng Liu;Yifen Wang;Shiying Xuan;Shuixian Du;Mengke Wang;Yongning Xin
29 Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis 期刊论文 Ma Xuefeng;Liu Shousheng;Zhang Jie;Dong Mengzhen;Wang Yifen;Wang Mengke;Xin Yongning
30 Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population 期刊论文 Mengzhen Dong;Shousheng Liu;Yifen Wang;Shiying Xuan;Mengke Wang;Yongning Xin
31 ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19 期刊论文 Mengzhen Dong;Jie Zhang;Xuefeng Ma;Jie Tan;Lizhen Chen;Shousheng Liu;Yongning Xin;Likun Zhuang
32 肝纤维化遗传易感性研究进展 期刊论文 朱慧玲;刘守胜;徐月;廖宋龄;辛永宁
33 FABP2 rs1799883基因多态性与非乙醇性脂肪性肝病及冠心病的相关性 期刊论文 韩易;刘守胜;赵真真;辛永宁;宣世英
34 Tribbles 同源蛋白1 rs2954029 单核苷酸多态性与非酒精性 脂肪性肝病及冠状动脉粥样硬化性心脏病的相关性分析 期刊论文 刘群;栾桂萍;高慧;赵本田;杜水仙;刘守胜;辛永宁
35 FADS2 rs3834458基因多态性与中国汉族人群冠心病易感性的相关性研究 期刊论文 徐颖誉;赵真真;刘守胜;肖颖朴;苗梦媛;辛永宁
36 Apolipoprotein A5 gene polymorphisms are associated with non-alcoholic fatty liver disease 期刊论文 Xu Yue;Lu Lin-Lin;Liu Shou-Sheng;Du Shui-Xian;Zhu Hui-Ling;Dong Quan-Jiang;Xin Yong-Ning
37 肠道菌群介导的免疫反应在慢性HBV 感染中的作用 期刊论文 高慧;刘守胜;赵真真;辛永宁
38 Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis 期刊论文 Dongli Han;Shousheng Liu;Wenwen Jin;Zhenzhen Zhao;Zengzhi Zhang;Yongning Xin;Jie Chen
39 过氧化物酶体增殖激活物受体γ辅激活因子1α rs8192678位点单核苷酸多态性与非酒精性脂肪性肝病发病风险的关系 期刊论文 张青;刘守胜;孙宝凯;张梅;辛永宁
40 Association between NAFLD and Risk of ColorectalAdenomain Chinese Han Population 期刊论文 Yuan Li;Shousheng Liu;Yuqiang Gao;Huan Ma;Shuhui Zhan;Yan Yang;Yongning Xin;Shiying Xuan
41 Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population 期刊论文 Gao Hui;Liu Shousheng;Zhao Zhenzhen;Yu Xinjuan;Liu Qun;Xin Yongning;Xuan Shiying
42 TM6SF2在肝细胞癌组织中的表达及其生物信息学功能分析 期刊论文 肖剑寒;刘守胜;赵真真;辛永宁;宣世英
43 The Genetics of Clinical Liver Diseases: Insight into the TM6SF2 E167K Variant 期刊论文 Xiaoyu Zhang;Shousheng Liu;Quanjiang Dong;Yongning Xin;Shiying Xuan
44 Roles and regulatory mechanisms of miR-30b in cancer, cardiovascular disease, and metabolic disorders 期刊论文 Qing Zhang;Shousheng Liu;Jie Zhang;Xuefeng Ma;Mengzhen Dong;Baokai Sun;Yongning Xin
45 TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population 期刊论文 Liu Qun;Liu Shousheng;Zhao Zhenzhen;Zhao Bentian;Du Shuixian;Jin Wenwen;Xin Yongning
46 Role and effective therapeutic target of gut microbiota in NAFLD/NASH 期刊论文 Qun Liu;Shousheng Liu;Lizhen Chen;Zhenzhen Zhao;Shuixian Du;Quanjiang Dong;Yongning Xin;Shiying Xuan
47 Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis 期刊论文 Liu Shousheng;Ma Xuefeng;Zhao Jie;Du Shuixian;Zhang Jie;Dong Mengzhen;Xin Yongning
48 Association of TCF7L2 rs7903146 Gene Polymorphism with the Risk of NAFLD and CAD in the Chinese Han Population 期刊论文 Yan Xin;Jin Wenwen;Zhang Jie;Wang Mengke;Liu Shousheng;Xin Yongning
49 Diagnostic accuracy assessment of molecular prediction model for the risk of NAFLD based on MRI-PDFF diagnosed Chinese Han population 期刊论文 Qing Zhang;Shousheng Liu;Zhenzhen Zhao;Yongning Xin;Yueli Zhu;Wanjiang Yu;Kuirong Lv;Zhipeng Xu
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