【30870858】铁导致的alpha-突触核蛋白的聚集在帕金森病中的作用研究国家自然基金项目

铁导致的alpha-突触核蛋白的聚集在帕金森病中的作用研究

项目批准号： 30870858

批准年份： 2008

学科分类： H0912.神经退行性变及相关疾病

项目负责人：谢俊霞

资助类别：面上项目

负责人职称：教授

依托单位：青岛大学

资助金额： 40万元

关键词：铁;多巴胺能神经元;alpha-突触核蛋白;铁反应元件;帕金森病

起止时间： 2009-01-01到2011-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Activation of ATP-sensitive potassium channels enhanced iron uptake and iron-induced oxidative stress in SK-N-SH cells.	会议论文	Jiang H\|Xie J\|Song N\|Du X\|Xu H\|
2	IRP1 is activated by PKC-dependent phosphorylation in dopaminergic cell line MES23.5 cells.	会议论文	Wang J\|Xie J\|Song N\|Wang W\|Lv Z\|
3	Protective effects of curcumin on 6-OHDA-induced Parkinson's disease rat model.	会议论文	Du X\|Wang J\|Jiang H\|Xie J\|
4	Iron and Parkinson’s disease..	会议论文	Xie J\|
5	Role of alpha-synuclein aggregation and the Nrf2/ HO-1 pathway in iron-induced neurotoxicity.	会议论文	Xie J\|Xu H\|Song W\|Song N\|Yu X\|He Q\|Jiang H\|Schipper HM \|
6	Expression of iron-related proteins and alterations in iron content in the temporal cortex of parkinsonian patients.	会议论文	Du T\|Xie J\|Song N\|He q\|Yu X\|Jiang H\|
7	Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease.	期刊论文	Jiang H\|Xie J\|Xu H\|Song N\|Lv Z\|
8	. Iron induced alpha-synuclein aggregation in SK-N-SH cells. 4th Beijing International Symposium on Neurodegenerative Diseases and Stroke (BINS)	会议论文	Song N\|Li W\|Jiang H\|Xie J\|
9	Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells.	期刊论文	Li W\|Jiang H\|Song N\|Xie J\|
10	高铁饮食致 C57BL/6 小鼠黑质 DA 多巴胺能神经元选择性损伤的研究	期刊论文	谢俊霞\|吕占云\|姜宏\|徐华敏\|
11	Iron-induced alpha-synuclein aggregation is involved in its toxicity in neuroblastoma cells.4th Beijing International Symposium on Neurodegenerative Diseases and Stroke (BINS)	会议论文	Jiang H\|Song N\|Xie J\|He Q\|Lv Z\|
12	Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA Lesioned Rats.	会议论文	Wang J\|Xie J\|Jiang H\|
13	.Iron metabolism and Parkinson’s disease	会议论文	Xie J\|Jiang H\|
14	Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells.	期刊论文	Jiang H\|Du X\|Xie J\|Wang J\|
15	Iron and alpha-synuclein. Brain iron metabolism and neurodegenerative disease meeting.	会议论文	Jiang H\|Xie J\|
16	Activation of ATP-sensitive potassium channels enhances DMT1-mediated ferrous iron uptake in SK-N-SH cells.	会议论文	Song N\|Du X\|Xu H\|Jiang H\|Xie J\|
17	Up-regulation of DMT1+IRE and down-regulation of FP1 are involved in 6-hydroxydopamine-induced neurotoxicity	会议论文	Xie J\|Jiang H\|
18	Rg1 protects the MPP(+)-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake.	期刊论文	Xu H\|Wang J\|Jiang H\|Xie J\|
19	Rg1 Protects Iron-Induced Neurotoxicity Through Antioxidant and Iron Regulatory Proteins in 6-OHDA-Treated MES23.5 Cells.	期刊论文	Jiang H\|Xu H\|Xie J\|
20	Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells.	期刊论文	Song N\|He Q\|Wang R\|Xu H\|Jiang H\|Xie J\|
21	携带人 alpha- 突触核蛋白真核重组质粒构建及其 SK-N-SH 细胞表达。	期刊论文	谢俊霞\|宋宁\|姜宏\|和青\|杜婷婷\|
22	Mysregulation of iron in Parkinson's disease and its relation to the dopaminergic cell death.	会议论文	Xie J\|Jiang H\|
23	Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent.	会议论文	Jiang H\|Song N\|Wang J\|Xie J\|Xu H\|Zhang S\|
24	The role of ATP-sensitive potassium channels on DMT1-mediated ferrous iron uptake in SK-N-SH cells.	会议论文	Du X\|Xu H\|Song N\|Xie J\|Jiang H\|
25	Ceruloplasmin is invovled in the nigral iron accumulation of 6-OHDA lesiond rats.	会议论文	Wang J\|Jiang H\|Xie J\|
26	Nifedipine reduces iron-overload induced dopamine neuron degeneration by inhibition of iron accumulation in the substantia nigra of rats.	会议论文	Jiang H\|Ma Z\|Xie J\|
27	Inhibition of divalent metal transporter 1-inducediron influx involved in the protective effect of Rg1 against MPP+.	会议论文	Xie J\|Jiang H\|Wang J\|Xu H\|
28	Iron transporters mis-regulation contributes to the nigral iron accumulation in Parkinson’s disease.	会议论文	Jiang H\|Xie J\|Wang J\|Song N\|
29	Oxidative Stress Partially Contributes to Iron-Induced Alpha-Synuclein Aggregation in SK-N-SH Cells.	期刊论文	Xie J\|Song N\|Jiang H\|Li W\|
30	Nifedipine reduces iron accumulation and dopamine neuron degeneration in the iron-overloaded substantia nigra of rats	会议论文	Ma Z\|Xie J\|
31	Ferroportin1 but not hephaestin was involved in the 6-hydroxydopamine induced iron accumulation in MES23.5 dopaminergic cells.	会议论文	Jiang H\|Wang J\|Xie J\|Song N\|
32	Role of alpha-synuclein aggregation in iron-induced neurotoxicity	会议论文	Jiang H\|He Q\|Li W\|Song N\|Xie J\|
33	Ferroportin1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson’s disease.	会议论文	Jiang H\|Wang J\|Xie J\|Song N\|
34	Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent.	期刊论文	Wang J\|Song N\|Xie J\|Zhang S\|Jiang H\|Xu H\|
35	Alpha-synuclein aggregation is involved in the iron toxicity to SK-N-SH neuroblastoma cells.	会议论文	Jiang H\|Li W\|He Q\|Song N\|Xie J\|
36	A novel protection by Rg1 on MPP+ induced iron accumulation by ROS and nuclear factor-kappaB signal pathway.	会议论文	Xie J\|Xu H\|Wang J\|Jiang H\|

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