乙肝恶性转化过程中病毒变异与炎症网络的交互作用机制
91529305
2015
H1801.肿瘤病因
曹广文
重大研究计划
教授
中国人民解放军第二军医大学
249万元
整合;肝细胞癌;乙肝病毒变异;炎症信号网络
2016-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3 | 期刊论文 | Chen Pei-zhan;Li Mian;Duan Xiao-hua;Jia Jing-ying;Li Jing-quan;Chu Rui-ai;Yu Chen;Han Jun-hua;Wang Hui |
| 2 | 病毒进化和免疫遗传在乙肝相关肝细胞癌预测和特异性预防中的作用 | 奖励 | 曹广文 |
| 3 | A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer | 期刊论文 | Yao Wenbo;Ba Qian;Li Xiaoguang;Li Huiliang;Zhang Shoude;Yuan Ya;Wang Feng;Duan Xiaohua;Li Jingquan;Zhang Weidong;Wang Hui |
| 4 | Tim-3 blockade promotes iNKT cell function to inhibit HBV replication | 期刊论文 | Xu Yong;Wang Zehua;Liu Yuan;Song Xiaojia;Wang Tixiao;Tan Siyu;Liang Xiaohong;Gao Lifen;Ma Chunhong |
| 5 | Prediction and prophylaxis of hepatocellular carcinoma occurrence and postoperative recurrence in chronic hepatitis B virus-infected subjects | 期刊论文 | Du Yan;Han Xue;Ding Yi-Bo;Yin Jianhua;Cao Guangwen |
| 6 | 一种乙型肝炎病毒基因组DNA的5-乙炔基-2’脱氧尿嘧啶核苷的标记和检测方法 | 专利 | 马春红 |
| 7 | Urban-Rural Disparity in Cancer Incidence, Mortality, and Survivals in Shanghai, China, During 2002 and 2015 | 期刊论文 | Li xiaopan;Deng Yang;Tang WN;Sun Q;Chen YC;Yang C;Yan B;Wang YY;Wang J;Wang S;Yang F;Ding yibo;Zhao GM;Cao Guangwen |
| 8 | Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women | 期刊论文 | Li Chenguang;Chen Peizhan;Duan Xiaohua;Wang Jing;Shu Bing;Li Xiaoguang;Ba Qian;Li Jingquan;Wang Yongjun;Wang Hui |
| 9 | HBV suppresses ZHX2 expression to promote proliferation of HCC through miR-155 activation. | 期刊论文 | Song Xiaojia;Tan Siyu;Wu Zhuanchang;Xu Leiqi;Wang Zehua;Xu Yong;Wang Tixiao;Gao Chengjiang;Gong Yaoqin;Liang Xiaohong;Gao Lifen;Spear Brett T;Ma Chunhong |
| 10 | Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma | 期刊论文 | Chen Peizhan;Li Bin;Zhu Yan;Chen Wei;Liu Xin;Li Mian;Duan Xiaohua;Yi Bin;Wang Jinghan;Liu Chen;Luo Xiangji;Li Xiaoguang;Li Jingquan;Liang Lijian;Yin Xiaoyu;Wang Hui;Jiang Xiaoqing |
| 11 | 人鼠嵌合肝小鼠模型的建立及在HBV致病研究中的应用 | 期刊论文 | 傅忠星;杨帆;王灵;张宏伟;曹广文 |
| 12 | Systematic network assessment of the carcinogenic activities of cadmium | 期刊论文 | Chen Peizhan;Duan Xiaohua;Li Mian;Huang Chao;Li Jingquan;Chu Ruiai;Ying Hao;Song Haiyun;Jia Xudong;Ba Qian;Wang Hui |
| 13 | Titanium dioxide nanoparticles prime a specific activation state of macrophages | 期刊论文 | Huang Chao;Sun Mayu;Yang Yang;Wang Feng;Ma Xueqi;Li Jingquan;Wang Yilong;Ding Qiurong;Ying Hao;Song Haiyun;Wu Yongning;Jiang Yiguo;Jia Xudong;Ba Qian;Wang Hui |
| 14 | Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells | 期刊论文 | Ba Qian;Huang Chao;Fu Yijing;Li Junyang;Li Jingquan;Chu Ruiai;Jia Xudong;Wang Hui |
| 15 | 癌症进化发育学:基于炎-癌转化研究的新学说 | 期刊论文 | 刘文斌;曹广文 |
| 16 | Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma | 期刊论文 | Liu Yan;Tan Xiaojie;Liu Wenbin;Chen Xi;Hou Xiaomei;Shen Dan;Ding Yibo;Yin Jianhua;Wang Ling;Zhang Hongwei;Yu Yongwei;Hou Jianguo;Thompson Timothy C.;Cao Guangwen |
| 17 | Cancer Evolution-Development: experience of hepatitis B virus-induced hepatocarcinogenesis | 期刊论文 | Liu wenbin;Wu Jianfeng;Du Yan;Cao Guangwen |
| 18 | Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers | 期刊论文 | Liu Yuan;Cheng Y;Xu Yong;Wang Zehua;Du Xianhong;Li Chunyang;Peng Jun;Gao Lifen;Liang Xiaohong;Ma Chunhong |
| 19 | Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and nonepigenetic manners | 期刊论文 | Xu Leiqi;Wu Zhuanchang;Tan Siyu;Wang Zehua;Lin Qinghai;Li Xiaoyan;Song Xiaojia;Liu Yuan;Song Yang;Zhang Jie;Peng Jun;Gao Lifen;Gong Yaoqin;Liang Xiaohong;Zuo Xiuli;Ma Chunhong |
| 20 | A genetic polymorphism affects the risk and prognosis of renal cell carcinoma: association with follistatin-like protein 1 expression | 期刊论文 | Liu Yan;Han Xue;Yu Yongwei;Ding Yibo;Ni Chong;Liu Wenbin;Hou Xiaomei;Li Zixiong;Hou Jianguo;Shen Dan;Yin Jianhua;Zhang Hongwei;Thompson Timothy C.;Tan Xiaojie;Cao Guangwen |
| 21 | 肝细胞癌:肝细胞和乙型病毒肝炎的共同进化 | 期刊论文 | 杨帆;马龙腾;曹广文 |
| 22 | Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-kappa B/IL-6/STAT3 axis | 期刊论文 | Zhang Hualin;Song Yang;Yang Huimin;Liu Zhiyan;Gao Lifen;Liang Xiaohong;Ma Chunhong |
| 23 | Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for Ovarian Cancer | 期刊论文 | Li Xiaoguang;Zhou Yu;Liu Yanling;Zhang Xu;Chen Tao;Chen Kerong;Ba Qian;Li Jingquan;Liu Hong;Wang Hui |
| 24 | 一种阻断乙型肝炎病毒慢性感染的抗Tim-3抗体和α-galcer的组合及应用 | 专利 | 马春红 |
| 25 | Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice | 期刊论文 | Du xianhong;Wu Zhuanchang;Xu Yong;Liu Yuan;Liu Wen;Wang Tixiao;Li Chunyang;Zhang Cuijuan;Yi Fan;Gao Lifen;Liang Xiaohong;Ma Chunhong |
| 26 | 乙型肝炎病毒在致癌过程中的“末路变异”问题 | 期刊论文 | 王灵;曹广文 |
| 27 | 癌症进化发育学 | 专著 | 曹广文 |
| 28 | Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication. | 期刊论文 | Zhao Di;Jiang Xuemei;Xu Yong;Yang Huimin;Gao Dongni;Li Xueen;Gao Lifen;Ma Chunhong;Liang Xiaohong |
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