KLF4-RANK轴调控BMSCs成骨分化机制及其在骨骼衰老中的作用
81871099
2018
H1902.衰老相关疾病
陈晓
面上项目
副研究员
中国人民解放军第二军医大学
61万元
间充质干细胞;骨骼衰老;成骨分化;RANK受体;骨质疏松症
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-kappa B, MAPK and AKT pathways | 期刊论文 | Zhi Xin;Fang Chao;Gu Yanqiu;Chen Huiwen;Chen Xiaofei;Cui Jin;Hu Yan;Weng Weizong;Zhou Qirong;Wang Yajun;Wang Yao;Jiang Hao;Li Xiaoqun;Cao Liehu;Chen Xiao;Su Jiacan |
| 2 | Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment | 期刊论文 | Lipeng Wang;Hao Zhang;Sicheng Wang;Xiao Chen;Jiacan Su |
| 3 | The horizon of bone organoid: A perspective on construction and application | 期刊论文 | Shuangshuang Chen;Xiao Chen;Zhen Geng;Jiacan Su |
| 4 | Intra-articular nanodrug delivery strategies for treating osteoarthritis | 期刊论文 | Dongyang Zhou;Fengjin Zhou;Shihao Sheng;Yan Wei;Xiao Chen;Jiacan Su |
| 5 | Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone | 期刊论文 | Wang Yajun;Cui Jin;Gu Zhengrong;Fang Chao;Hu Yan;Weng Weizong;Li Xiaoqun;Zhou Qirong;Chen Huiwen;Zhang Hao;Guo Jiawei;Zhuang Xinchen;Sheng Shihao;Wang Sicheng;Chen Xiao;Su Jiacan |
| 6 | Exosome-guided bone targeted delivery of antagomir-188 as an anabolic therapy for bone loss | 期刊论文 | Hu Yan;Li Xiaoqun;Zhang Qin;Gu Zhengrong;Luo Ying;Guo Jiawei;Wang Xiuhui;Jing Yingying;Chen Xiao;Su Jiacan |
| 7 | Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases | 期刊论文 | Jiawei Guo;Fuxiao Wang;Yan Hu;Ying Luo;Yan Wei;Ke Xu;Hao Zhang;Han Liu;Lumin Bo;Shunli Lv;Shihao Sheng;Xinchen Zhuang;Tao Zhang;Can Xu;Xiao Chen;Jiacan Su |
| 8 | Development of 3-mercaptopropyltrimethox-ysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix | 期刊论文 | Gu Yanqiu;Chen Xiao;Wang Yao;Liu Yue;Zheng Leyi;Li Xiaoqun;Wang Rong;Wang Shaozhan;Li Shengnan;Chai Yifeng;Su Jiacan;Yuan Yongfang;Chen Xiaofei |
| 9 | 一种千层纸素A在治疗骨质疏松和促进骨折愈合中的应用 | 专利 | 苏佳灿;陈晓;李啸群;陈啸飞;王立鹏;张浩 |
| 10 | 骨质疏松性骨折诊疗误区与"三位一体"骨修复策略 | 期刊论文 | 胡衍;陈晓;苏佳灿 |
| 11 | Loss of Bcl-3 delays bone fracture healing through activating NF-κB signaling in mesenchymal stem cells | 期刊论文 | Fuxiao Wang;Jiawei Guo;Yili Wang;Yan Hu;Hao Zhang;Jiao Chen;Yingying Jing;Liehu Cao;Xiao Chen;Jiacan Su |
| 12 | Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion inhibiting subchondral osteoclast fusion | 期刊论文 | Fang Chao;Guo Jia-wei;Wang Ya-jun;Li Xiao-qun;Zhang Hao;Cui Jin;Hu Yan;Jing Ying-ying;Chen Xiao;Su Jia-can |
| 13 | Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-kappa B, MAPK and Akt pathways | 期刊论文 | Chen Huiwen;Fang Chao;Zhi Xin;Song Shaojun;Gu Yanqiu;Chen Xiaofei;Cui Jin;Hu Yan;Weng Weizong;Zhou Qirong;Wang Yajun;Wang Yao;Jiang Hao;Li Xiaoqun;Cao Liehu;Chen Xiao;Su Jiacan |
| 14 | Lactulose Suppresses Osteoclastogenesis and Ameliorates Estrogen Deficiency-Induced Bone Loss in Mice | 期刊论文 | Chen Xiao;Zhang Zheng;Hu Yan;Cui Jin;Zhi Xin;Li Xiaoqun;Jiang Hao;Wang Yao;Gu Zhengrong;Qiu Zili;Dong Xin;Li Yuhong;Su Jiacan |
| 15 | RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss | 期刊论文 | Hu Yan;Li Xiaoqun;Zhi Xin;Cong Wei;Huang Biaotong;Chen Huiwen;Wang Yajun;Li Yinghua;Wang Lipeng;Fang Chao;Guo Jiawei;Liu Ying;Cui Jin;Cao Liehu;Weng Weizong;Zhou Qirong;Wang Sicheng;Chen Xiao;Su Jiacan |
| 16 | A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction | 期刊论文 | Pan Panpan;Chen Xiao;Xing Huaran;Deng Yonghui;Chen Jingdi;Alharthi Fahad A;Alghamdi Abdulaziz A;Su Jiacan |
| 17 | Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle | 期刊论文 | Shuming Sun;Han Liu;Yan Hu;Yanpeng Wang;Mingri Zhao;Yijun Yuan;Yafei Han;Yingying Jing;Jin Cui;Xiaoxiang Ren;Xiao Chen;Jiacan Su |
| 18 | Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss | 期刊论文 | Li Xiaoqun;Wang Lipeng;Huang Biaotong;Gu Yanqiu;Luo Ying;Zhi Xin;Hu Yan;Zhang Hao;Gu Zhengrong;Cui Jin;Cao Liehu;Guo Jiawei;Wang Yajun;Zhou Qirong;Jiang Hao;Fang Chao;Weng Weizong;Chen Xiaofei;Chen Xiao;Su Jiacan |
| 19 | 骨质疏松性骨折治疗面临的挑战和解决途径 | 期刊论文 | 郭嘉炜;陈晓;苏佳灿 |
| 20 | L-plastin蛋白抑制剂在抑制破骨前体细胞融合中的应用 | 专利 | 苏佳灿;陈啸飞;陈晓;李啸群;王立鹏;顾妍秋 |
| 21 | 第三十二届上海市优秀发明金奖 | 奖励 | 苏佳灿;陈晓;智信;胡宏岗;赵庆杰;曹烈虎 |
| 22 | B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging | 期刊论文 | Fuxiao Wang;Jiawei Guo;Sicheng Wang;Yili Wang;Jiao Chen;Yan Hu;Hao Zhang;Ke Xu;Yan Wei;Liehu Cao;Xiao Chen;Yingying Jing;Jiacan Su |
| 23 | New insight into unexpected bone formation by denosumab | 期刊论文 | Lipeng Wang;Biaotong Huang;Xiao Chen;Jiacan Su |
| 24 | Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering | 期刊论文 | Xue Xu;Hu Yan;Wang Sicheng;Chen Xiao;Jing Yingying;Su Jiacan |
| 25 | Subchondral bone microenvironment in osteoarthritis and pain | 期刊论文 | Yan Hu;Xiao Chen;Sicheng Wang;Yingying Jing;Jiacan Su |
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