基于斑马鱼模型研究炎症状态下异烟肼经内质网应激-自噬通路诱发肝毒性的作用机制
81703624
2017
H3512.药物毒理
张云
青年科学基金项目
研究员
山东省科学院
20万元
异烟肼;斑马鱼;自噬;炎症状态;肝毒性
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Xiaoaiping induces developmental toxicity in zebrafish embryos through activation of ER stress, apoptosis and the Wnt pathway. | 期刊论文 | Juanjuan Li;Yun Zhang;Kechun Liu;Qiuxia He;Chen Sun;Jian Han;Liwen Han;Qingping Tian |
| 2 | Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos | 期刊论文 | Zhang Yun;Li Saiyu;Li Juanjuan;Han Liwen;He Qiuxia;Wang Rongchun;Wang Ximin;Liu Kechun |
| 3 | 基于模式生物斑马鱼研究炎症状态下的异烟肼肝脏毒性作用 | 会议论文 | 张云;岑娟;韩利文;何秋霞;江振洲;张陆勇;刘可春 |
| 4 | Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish | 期刊论文 | Huo Jingting;Yu Qinwei;Zhang Yun;Liu Kechun;Hsiao Chung-der;Jiang Zhenzhou;Zhang Luyong |
| 5 | Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa | 期刊论文 | Jiao Wei-Hua;Li Jing;Zhang Meng-Meng;Cui Jie;Gui Yu-Han;Zhang Yun;Li Jing-Ya;Liu Ke-Chun;Lin Hou-Wen |
| 6 | 基于模式生物斑马鱼在化合物毒性评价中的应用 | 会议论文 | 张云;刘可春 |
| 7 | 一种超灵敏亚铁离子荧光探针、制备方法与应用 | 专利 | 盛文龙;刘可春;张云;张轩铭;张姗姗;彭维兵 |
| 8 | 一种快速评价化合物对斑马鱼肝脏功能损伤作用的方法 | 专利 | 张云;刘可春;韩利文;王雪;何秋霞;孙晨;王希敏;楚杰;韩建;王荣春 |
| 9 | 基于模式生物斑马鱼研究抗结核药物的肝脏毒性及其毒性机制 | 会议论文 | 张云 |
| 10 | 雷公藤甲素经凋亡及自噬途径诱导斑马鱼肝毒性发生的机制研究 | 会议论文 | 霍婧婷;俞沁玮;张云;刘可春;萧崇德;江振洲;张陆勇 |
| 11 | 消癌平对斑马鱼胚胎的发育毒性及其作用机制研究 | 会议论文 | 张云;贾智莉;李娟娟;韩利文;江振洲;张陆勇;刘可春 |
| 12 | Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish | 期刊论文 | Yu Qinwei;Huo Jingting;Zhang Yun;Liu Kechun;Cai Yu;Xiang Ting;Jiang Zhenzhou;Zhang Luyong |
| 13 | PM2.5水溶性组分对斑马鱼的胚胎发育毒性研究 | 会议论文 | 张云;贾智莉;朱成悦;马瑞娇;刘可春 |
| 14 | Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway | 期刊论文 | Yun Zhang;Chao Wang;Zhi-li Jia;Rui-jiao Ma;Xue-fang Wang;Ke-chun Liu |
| 15 | The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae | 期刊论文 | Yun Zhang;Yue Zhang;Juanjuan Li;Yiming Chen;Liwen Han;Qiuxia He;Kechun Liu |
| 16 | 一种筛选具有保护斑马鱼肝功能活性化合物的方法 | 专利 | 张云;刘可春;韩利文;何秋霞;王雪;彭维兵;陈维云;王希敏;侯海荣;陈锡强 |
| 17 | 一种斑马鱼幼鱼取样器及其工作方法 | 专利 | 张云;刘可春;韩利文;何秋霞;王希敏;陈维云;邹玉 |
| 18 | Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae:Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway | 期刊论文 | Jia Zhi-Li;Cen Juan;Wang Jia-Bo;Zhang Feng;Xia Qing;Wang Xue;Chen Xi-Qiang;Wang Rong-Chun;Hsiao Chung-der;Liu Ke-Chun;Zhang Yun |
| 19 | 具有抗氧化应激损伤的脉红螺多肽及其制备方法与应用 | 专利 | 张姗姗;刘可春;李晓彬;张轩铭;张云;侯海荣;夏青;孙晨 |
| 20 | 基于斑马鱼模型的抗结核药物肝脏毒性比较研究 | 期刊论文 | 马瑞娇;贾智莉;王学芳;邬芳艳;朱成悦;萧崇德;张云;刘可春 |
| 21 | Septosones A-C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa | 期刊论文 | Gui Yu -Han;Jiao Wei-Hua;Zhou Mi;Zhang Yun;Zeng De-Quan;Zhu Hong-Rui;Liu Ke-Chun;Sun Fan;Chen Hai-Feng;Lin Hou-Wen |
| 22 | Particulate matter (PM10) induces cardiovascular developmental toxicity in zebrafish embryos and larvae via the ERS, Nrf2 and Wnt pathways | 期刊论文 | Juan Cen;Zhi-li Jia;Cheng-yue Zhu;Xue-fang Wang;Feng Zhang;Wei-yun Chen;Ke-chun Liu;Sai-yu Li;Yun Zhang |
| 23 | 一种用于研究斑马鱼再生修复功能的装置 | 专利 | 王雪;刘可春;张云;韩利文;陈锡强;夏青;王荣春;王希敏 |
| 24 | 吡嗪酰胺对斑马鱼胚胎发育和氧化应激效应的影响 | 期刊论文 | 李娟娟;韩利文;邱昌辉;刘可春;孙桂金;何秋霞;田青平;张云 |
| 25 | Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish | 期刊论文 | Zhang Yun;Cen Juan;Jia Zhili;Hsiao Chung Der;Xia Qing;Wang Xue;Chen Xiqiang;Wang Rongchun;Jiang Zhenzhou;Zhang Luyong;Liu Kechun |
| 26 | Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish | 期刊论文 | Liu Li;Wu Fang-yan;Zhu Cheng-yue;Zou Hong-yuan;Kong Rui-qi;Ma Yu-kui;Su Dan;Song Guo-qiang;Zhang Yun;Liu Ke-chun |
| 27 | Discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti-inflammatory activity in vivo zebrafish model | 期刊论文 | Gui Yu-Han;Liu Li;Wu Wei;Zhang Yun;Jia Zhi-Li;Shi Yong-Ping;Kong Hao-Tian;Liu Ke-Chun;Jiao Wei-Hua;Lin Hou-Wen |
| 28 | The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish | 期刊论文 | Qing Xia;Kechun Liu;Zhili Jia;Xiaobin Li;Shanshan Zhang;Liwen Han;Guijin Sun;Yun Zhang |
| 29 | 基于斑马鱼模型的药物早期安全性评价关键技术的建立与应用 | 奖励 | 刘可春;张云;何秋霞;靳梦;孙晨;王荣春;夏青;张姗姗;张轩铭;王雪;李晓彬;陈希强 |
| 30 | Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish | 期刊论文 | Li Juanjuan;Zhang Yun;Han Liwen;Tian Qingping;He Qiuxia;Wang Ximin;Sun Chen;Han Jian;Liu Kechun |
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