研究细胞/组织器官衰老与机体衰老关联机制的条件性敲入小鼠模型的建立与分析
81571374
2015
H1903.老年医学研究新技术与新方法
刘宝华
面上项目
教授
深圳大学
120万元
动物模型;快速老化小鼠;组织器官衰老;儿童早老症;衰老机制
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Lamin A, an activator of longevity/anti-aging SIRT1 protein | 专利 | 周中军;刘宝华 |
| 2 | Aging And Aging-Related Diseases | 专著 | Minxian Qian;Baohua Liu |
| 3 | Vascular endothelium-targeted Sirt7 gene therapy rejuvenates aging tissues and extends lifespan in Hutchinson-Gilford progeria model | 期刊论文 | Shimin Sun;Weifeng Qin;Xiaolong Tang;Yuan Meng;Wenjing Hu;Shuju Zhang;Minxian Qian;Zuojun Liu;Xinyue Cao;Qiuxiang Pang;Bosheng Zhao;Zimei Wang;Zhongjun Zhou;Baohua Liu |
| 4 | A SIRT1-centered circuitry regulates breast cancer stemness and metastasis | 期刊论文 | Shi Lei;Tang Xiaolong;Qian Minxian;Liu Zuojun;Meng Fanbiao;Fu Li;Wang Zimei;Zhu Wei-Guo;Huang Jian-Dong;Zhou Zhongjun;Liu Baohua |
| 5 | Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria | 期刊论文 | Qian M.;Liu Z.;Peng L.;Tang X.;Meng F.;Ao Y.;Zhou M.;Wang M.;Cao X.;Qin B.;Wang Z.;Zhou Z.;Wang G.;Gao Z.;Xu J.;Liu B. |
| 6 | SIRT7 antagonizes TGF-beta signaling and inhibits breast cancer metastasis | 期刊论文 | Tang X.;Shi L.;Xie N.;Liu Z.;Qian M.;Meng F.;Xu Q.;Zhou M.;Cao X.;Zhu W. G.;Liu B. |
| 7 | Advances in pharmacological interventions of aging in mice | 期刊论文 | Minxian Qian;Baohua Liu |
| 8 | SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis | 期刊论文 | Zuojun Liu;Minxian Qian;Xiaolong Tang;Wenjing Hu;Shimin Sun;Guo Li;Shuju Zhang;Fanbiao Meng;Xinyue Cao;Jie Sun;Cheng Xu;Bing Tan;Qiuxiang Pang;Bosheng Zhao;Zimei Wang;Youfei Guan;Xiongzhong Ruan;Baohua Liu |
| 9 | Sirt6 deacetylase activity regulates circadian rhythms via Per2 | 期刊论文 | Shimin Sun;Zuojun Liu;Yukun Feng;Lei Shi;Xinyue Cao;Yanlin Cai;Baohua Liu |
| 10 | Use of endothelial progenitor cells (EPCs) in rejuvenating the microvasculature, preventing aging and treating age-related diseases | 专利 | 刘宝华;孙世民 |
| 11 | An agent that enables Sirt7 gene expression and the use thereof | 专利 | 刘宝华;孙世民;唐小龙 |
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