颅脑创伤后血脑屏障继发性损伤机制及干预
81330029
2013
H0910.神经损伤、修复与再生
张建宁
重点项目
教授
天津医科大学
290万元
神经免疫;继发性脑损伤;颅脑创伤;血脑屏障;神经炎症
2014-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury | 期刊论文 | Tian Ye;Salsbery Breia;Wang Min;Yuan Hengjie;Yang Jing;Zhao Zilong;Wu Xiaoping;Zhang Yanjun;Konkle Barbara A.;Thiagarajan Perumal;Li Min;Zhang Jianning;Dong Jing-fei |
| 2 | miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis | 期刊论文 | Ge Xintong;Huang Shan;Gao Huabin;Han Zhaoli;Chen Fanglian;Zhang Shishuang;Wang Zengguang;Kang Chunsheng;Jiang Rongcai;Yue Shuyuan;Lei Ping;Zhang Jianning |
| 3 | Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor alpha membrane trafficking to promote breast cancer progression | 期刊论文 | Li Jie;Bai Tai-Ran;Gao Shan;Zhou Zhuan;Peng Xue-Mei;Zhang Li-Song;Dou Dao-Lei;Zhang Zhi-Song;Li Lu-Yuan |
| 4 | Use of non-contact hopping probe ion conductance microscopy to investigate dynamic morphology of live platelets | 期刊论文 | Liu Xiao;Li Ying;Zhu Hui;Zhao Zilong;Zhou Yuan;Zaske Ana-Maria;Liu Li;Li Min;Lu Hujie;Liu Wei;Dong Jing-Fei;Zhang Jianning;Zhang Yanjun |
| 5 | von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury. | 期刊论文 | Wu Yingang;Liu Wei;Zhou Yuan;Hilton Tristan;Zhao Zilong;Liu Wei;Wang Min;Yeon Jason;Houck Katie;Thiagarajan Perumal;Zhang Fangyi;Shi Fu-Dong;Wu Xiaoping;Li Min;Zhang Jianning;Dong Jing-Fei |
| 6 | MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation | 期刊论文 | Lv Jingfang;Zeng Yong;Qian Yu;Dong Jingfei;Zhang Zhixiang;Zhang Jianning |
| 7 | Vascular endothelial growth factor suppresses TNFSF15 production in endothelial cells by stimulating miR-31 and miR-20a expression via activation of Akt and Erk signals | 期刊论文 | Deng Hui-Ting;Liu Hai-Lin;Zhai Bei-Bei;Zhang Kun;Xu Guo-Ce;Peng Xue-Mei;Zhang Qiang-Zhe;Li Lu-Yuan |
| 8 | Cellular microparticles and pathophysiology of traumatic brain injury | 期刊论文 | Zhao Zilong;Zhou Yuan;Tian Ye;Li Min;Dong Jing-fei;Zhang Jianning |
| 9 | IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury | 期刊论文 | Gao Weiwei;Li Fei;Zhou Ziwei;Xu Xin;Wu Yingang;Zhou Shuai;Yin Dongpei;Sun Dongdong;Xiong Jianhua;Jiang Rongcai;Zhang Jianning |
| 10 | High-dose glucocorticoid aggravates TBI-associated corticosteroid insufficiency by inducing hypothalamic neuronal apoptosis | 期刊论文 | Zhu Hui;Zhao Zilong;Zhou Yuan;Chen Xin;Li Ying;Liu Xiao;Lu Hujie;Zhang Yanjun;Zhang Jianning |
| 11 | Analysis of the association of fluid balance and short-term outcome in traumatic brain injury | 期刊论文 | Zhao Zilong;Wang Dong;Jia Ying;Tian Ye;Wang Yi;Wei Yingsheng;Zhang Jianning;Jiang Rongcai |
| 12 | Electrical stimulation improved cognitive deficits associated with traumatic brain injury in rats | 期刊论文 | Zheng Zhi-tong;Dong Xin-long;Li Ya-dan;Gao Wei-wei;Zhou Yuan;Jiang Rong-cai;Yue Shu-yuan;Zhou Zi-wei;Zhang Jian-ning |
| 13 | Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury | 期刊论文 | Zhou Zi-wei;Li Ya-dan;Gao Wei-wei;Chen Jie-li;Yue Shu-yuan;Zhang Jian-ning |
| 14 | 阿托伐他汀对颅脑外伤后小胶质细胞激活的影响 | 期刊论文 | 郁龚杰;孙东东;曾勇;高伟伟;陈思亲;张建宁 |
| 15 | Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms | 期刊论文 | Wang Dong;Xu Xin;Wu Yin-Gang;Lyu Li;Zhou ZW;Zhang JN |
| 16 | miR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats | 期刊论文 | Ge Xintong;Han Zhaoli;Chen Fanglian;Wang Haichen;Zhang Baoliang;Jiang Rongcai;Lei Ping;Zhang Jianning |
| 17 | Phosphoinositide 3-Kinase Pathway Mediates Early Aldosterone Action on Morphology and Epithelial Sodium Channel in Mammalian Renal Epithelia | 期刊论文 | Zhou Yuan;Chen Xuewei;Liu Xiao;Lu Hujie;Li Ying;Zhu Hui;An Gaihong;Zhang Na;Zhang Jianning;Ma Qiang;Zhang Yanjun |
| 18 | Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury | 期刊论文 | Zhou Zi-wei;Li Fei;Zheng Zhi-tong;Li Ya-dan;Chen Tong-heng;Gao Wei-wei;Chen Jie-li;Zhang Jian-ning |
| 19 | Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice | 期刊论文 | Zhou Yuan;Cai Wei;Zhao Zilong;Hilton Tristan;Wang Min;Yeon Jason;Liu Wei;Zhang Fangyi;Shi Fu-Dong;Wu Xiaoping;Thiagarajan Perumal;Li Min;Zhang Jianning;Dong Jing-fei |
| 20 | Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic updates brain injury | 期刊论文 | Xu Xin;Yin Dongpei;Ren Honglei;Gao Weiwei;Li Fei;Sun Dongdong;Wu Yingang;Zhou Shuai;Li Lyu;Yang Mengchen;Xiong Jianhua;Han Lulu;Jiang Rongcai;Zhang Jianning |
| 21 | Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury | 期刊论文 | Xu Xin;Gao Weiwei;Cheng Shiqi;Yin Dongpei;Li Fei;Wu Yingang;Sun Dongdong;Zhou Shuai;Wang Dong;Zhang Yongqiang;Jiang Rongcai;Zhang Jianning |
| 22 | VEGI attenuates the inflammatory injury and disruption of blood-brain barrier partly by suppressing the TLR4/NF-kappa B signaling pathway in experimental traumatic brain injury | 期刊论文 | Gao Weiwei;Zhao Zilong;Yu Gongjie;Zhou Ziwei;Zhou Yuan;Hu Tingting;Jiang Rongcai;Zhang Jianning |
| 23 | Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-kappaB pathway and the NLRP3 inflammasome may be involved in the mechanism | 期刊论文 | Yin Dongpei;Zhou Shuai;Xu Xin;Gao Weiwei;Li Fei;Ma Yuyang;Sun Dongdong;Wu Yingang;Guo Qi;Liu Huimin;Han Lulu;Wang Zengguang;Wang Yi;Zhang Jianning |
| 24 | Perturbation of epithelial apicobasal polarity by rhomboid family-1 gene overexpression | 期刊论文 | Peng Xue-Mei;Gao Shan;Deng Hui-Ting;Cai Hong-Xing;Zhou Zhuan;Xiang Rong;Zhang Qiang-Zhe;Li Lu-Yuan |
| 25 | Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice | 期刊论文 | Zhao Zilong;Wang Min;Tian Ye;Hilton Tristan;Salsbery Breia;Zhou Eric Z.;Wu Xiaoping;Thiagarajan Perumal;Boilard Eric;Li Min;Zhang Jianning;Dong Jing-fei |
| 26 | 脂多糖对小胶质细胞血管内皮生长因子表达的影响 | 期刊论文 | 曾勇;吕靖芳;郁龚杰;高伟伟;张建宁 |
| 27 | TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. | 期刊论文 | Yang Gui-Li;Zhao Zilong;Qin Ting-Ting;Wang Dong;Chen Lijuan;Xiang Rong;Xi Zhen;Jiang Rongcai;Zhang Zhi-Song;Zhang Jianning;Li Lu-Yuan |
| 28 | Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury | 期刊论文 | Zhang Jianning;Zhang Fangyi;Dong Jing-fei |
| 29 | miR-21 improves the neurological outcome after traumatic brain injury in rats | 期刊论文 | Ge Xin-Tong;Lei Ping;Wang Hai-Chen;Zhang An-Ling;Han Zhao-Li;Chen Xin;Li Sheng-Hui;Jiang Rong-Cai;Kang Chun-Sheng;Zhang Jian-Ning |
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