新型ATP敏感性钾通道开放剂IPT对帕金森病模型神经保护作用的细胞与分子机制研究

30572172
2005
H3501.神经精神药物药理
胡刚
面上项目
教授
南京医科大学
33万元
埃他卡林;ATP敏感性钾通道开放剂;神经保护;靶标..;帕金森病
2006-01-01到2008-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Kir6.2 knockout alters neurotransmitter release in mouse striatum: an in vivo microdialysis study. 期刊论文
2 Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils. 期刊论文
3 Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. 期刊论文
4 亲代谢型谷氨酸受体和ATP敏感性钾通道与帕金森病的相关性研究 奖励
5 Iptakalim ameliorates MPP(+)-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoK(ATP) channels. 期刊论文
6 Iptakalim alleviated the increase of extracellular dopamine and glutamate induced by 1-methyl-4-phenylpyridinium ion in rat striatum. 期刊论文
7 Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats. 期刊论文
8 Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. 期刊论文
9 Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. 期刊论文
10 Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. 期刊论文
11 Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation. 期刊论文
12 Aquaporin 4 regulates the effects of ovarian hormones on monoamine neurotransmission. 期刊论文
13 Opening of microglial K channels inhibits rotenone-induced neuroinflammation. 期刊论文
14 KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes. 期刊论文
15 Alterations of striatal neurotransmitter release in aquaporin-4 deficient mice: An in vivo microdialysis study. 期刊论文
16 ATP-sensitive potassium channel opener iptakalim protects against MPP-induced astrocytic apoptosis via mitochondria and mitogen-activated protein kinase signal pathways. 期刊论文
17 Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. 期刊论文
18 Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes. 期刊论文
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