铂类组蛋白去乙酰化酶抑制剂的设计合成、活性评价及其靶向作用研究

21371135
2013
B0706.药物化学生物学
徐靖源
面上项目
教授
天津医科大学
80万元
抗肿瘤活性;孪药;铂类靶点药物;组蛋白去乙酰化酶抑制剂;细胞生物学
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Scalene-tricopper(II) bridged by 5-(1H-benzo[d]imidazol-2-yl-1H-imidazole-4-carboxylic acid: Synthesis, crystal structure and magnetic properties 期刊论文 Jia Shao;Qiang Ge;Yan Ouyang;Cheng-Zhi Xie;Xiao-Tong Zhang;Jing-Yuan Xu;Yves Journaux
2 A mononuclear nickel(II) complex based on polypyridyl ligand: synthesis, characterization, and biological activity 期刊论文 Yan Ouyang;Zhao Xiao-Fei;Qiao Xin;Zhang Ran;Bao Wei-Guo;Xie Cheng-Zhi;Xu Jing-Yuan
3 Synthesis, characterization, and magnetochemical properties of two Mn-4 clusters derived from 2-pyridinecarboxaldehyde Schiff base ligands 期刊论文 Tian He;Qiao Xin;Xie Cheng-Zhi;Ouyang Yan;Xu Jingyuan
4 铝离子荧光探针 专利 徐靖源;张晓彤;乔鑫
5 氨基噻唑酮Cu(Ⅱ)核酸酶的合成、结构及活性研究 期刊论文 邵佳;徐靖源
6 基于螯合诱导荧光增强的锌离子荧光探针及其应用 专利 徐靖源;葛强;谢承志
7 Two series of novel 3D potentially porous heterometallic Cu-Ln coordination frameworks assembled by 3,4-pyridinedicarboxylic acid with different topologies and channels: syntheses, structures, luminescence and magnetic properties 期刊论文 Liu Xuan-Wen;Guo Rui;Liu He;Yu Ye-Qi;Qi Xi-Wei;Xu Jing-Yuan;Xie Cheng-Zhi
8 Two polypyridyl copper(II) complexes: synthesis, crystal structure and interaction with DNA and serum protein in vitro 期刊论文 Zhao Xiao-Fei;Ouyang Yan;Liu Yan-Zhao;Su Qiao-Juan;Tian He;Xie Cheng-Zhi;Xu Jing-Yuan
9 Three Pt(II) complexes based on thiosemicarbazone: synthesis, HSA interaction, cytotoxicity, apoptosis and cell cycle arrestin 期刊论文 Lin Xu-Dong;Liu Ya-Hong;Xie Cheng-Zhi;Bao Wei-Guo;Shen Jun;Xu Jing-Yuan
10 Synthesis, Structure, DNA Binding, and Magnetic Properties of Dicobalt (II/III, III/III) Complexes Based on 5-(1H-benzo[d]imidazol-2-yl)-1H-imidazole-4-carboxylic Ligand 期刊论文 Liu Wei;Shao Jia;Lian Wen-Jing;Xie Cheng-Zhi;Xu Jing-Yuan
11 Biological evaluation of a cytotoxic 2-substituted benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells 期刊论文 Qiao Xin;Ma Zhong-Ying;Shao Jia;Bao Wei-Guo;Xu Jing-Yuan;Qiang Zhao-Yan;Lou Jian-Shi
12 Association of structural modifications with bioactivity in three new copper(II) complexes of Schiff base ligands derived from 5-chlorosalicylaldehyde and amino acids 期刊论文 Li Ang;Liu Ya-Hong;Yuan Ling-Zhi;Ma Zhong-Ying;Zhao Chun-Lai;Xie Cheng-Zhi;Bao Wei-Guo;Xu Jing-Yuan
13 A 1-D alternating copper(II) chain based on three acetate-bridging modes: synthesis, crystal structure, DNA binding and magnetic properties 期刊论文 Zhao Chun-Lai;Xie Li-Fu;Li Bing;Qiao Xin;Xie Cheng-Zhi;Bao Wei-Guo;Xu Jing-Yuan
14 Synthesis, crystal structures, DNA binding, and cytotoxicity activities of two copper(II) complexes based on unsymmetrical tripodal ligands 期刊论文 Zhang Xiao-Tong;Ma Zhong-Ying;Zhao Chuan;Zhou Qi-Ji;Xie Cheng-Zhi;Xu Jing-Yuan
15 Two dpa-based zinc(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies 期刊论文 Zhang Yong-Po;Ma Zhong-Ying;Gao Chun-Yan;Qiao Xin;Tian Jin-Lei;Gu Wen;Liu Xin;Xu Jing-Yuan;Zhao Jin-Zhong;Yan Shi-Ping
16 A thiosemicarbazone copper(II) complex as a potential anticancer agent 期刊论文 Ma Zhong-Ying;Shao Jia;Bao Wei-Guo;Qiang Zhao-Yan;Xu Jing-Yuan
17 Thiosemicarbazone Cu(II) and Zn(II) complexes as potential anticancer agents: Syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction activity 期刊论文 Shao Jia;Ma Zhong-Ying;Li Ang;Liu Ya-Hong;Xie Cheng-Zhi;Qiang Zhao-Yan;Xu Jing-Yuan
18 Synthesis, characterization, DNA interaction, cytotoxicity, and apoptosis induction of a mixed-ligand copper(II) complex 期刊论文 Xie Cheng-Zhi;Sun Meng-Meng;Li Shao-Hua;Zhang Xiao-Tong;Qiao Xin;Yan Ouyang;Xu Jing-Yuan
19 Novel Zn(II)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene 期刊论文 Lin Xu-Dong;Peng Biao;Li Shao-Yong;Shao Jia;Li Qing-Zhong;Xie Cheng-Zhi;Xu Jing-Yuan
20 Nuclease activity and protein-binding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex 期刊论文 Shao Jia;Bao Wei-Guo;Tian He;Li Bing;Zhao Xiao-Fei;Qiao Xin;Xu Jing-Yuan
21 A mixed-ligand copper(II) complex that inhibits growth and induces apoptosis by DNA targeting in human epithelial cervical cancer cells 期刊论文 Ma Zhong-Ying;Qiao Zheng;Wang Dong-Bo;Hou Xuan;Qiao Xin;Xie Cheng-Zhi;Qiang Zhao-Yan;Xu Jing-Yuan
22 Mixed-ligand copper(II) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity 期刊论文 Lian Wen-Jing;Wang Xin-Tian;Xie Cheng-Zhi;Tian He;Song Xue-Qing;Pan He-Ting;Qiao Xin;Xu Jing-Yuan
23 Four Cu(II) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity 期刊论文 Liu Ya-Hong;Li Ang;Shao Jia;Xie Cheng-Zhi;Song Xue-Qing;Bao Wei-Guo;Xu Jing-Yuan
24 Four related mixed-ligand nickel(II) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity 期刊论文 Gao Chun-Yan;Ma Zhong-Ying;Zhang Yong-Po;Li Si-Tong;Gu Wen;Liu Xin;Tian Jin-Lei;Xu Jing-Yuan;Zhao Jin-Zhong;Yan Shi-Ping
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