非经典泛素修饰蛋白的化学合成方法及应用
91753205
2017
B0702.生物分子的化学生物学
刘磊
重大研究计划
教授
清华大学
300万元
蛋白质化学合成;蛋白质翻译后修饰;非经典泛素化修饰;泛素探针;蛋白质泛素化
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop | 期刊论文 | Lu Lining;Guo Yu;Wang Tian;Liang Lujun;Zhao Suwen;Wang Feng;Liu Lei |
| 2 | Semisynthesis of Ubiquitin and SUMO-Rhodamine 110-Glycine through Aminolysis of Boc-Protected Thioester Counterparts | 期刊论文 | Fan Jian;Ye Yinshan;Chu Guochao;Zhang Zhongping;Fu Yao;Li Yi-Ming;Shi Jing |
| 3 | Efficient semi-synthesis of ubiquitin-7-amino-4-methylcoumarin | 期刊论文 | Chu Guo-Chao;Bai Jing-Si;Kong Yi-Fu;Fan Jian;Sun Shuai-Shuai;Xu Hua-Jian;Shi Jing;Li Yi-Ming |
| 4 | Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative | 期刊论文 | Man Pan;Qingyun Zheng;Yuanyuan Yu;Huasong Ai;Yuan Xie;Xin Zeng;Chu Wang;Lei Liu;Minglei Zhao |
| 5 | 泛素化核小体复合物的结构机制研究进展 | 期刊论文 | 徐子昱;艾华松;孙茂甡;田家昆;刘磊 |
| 6 | Efficient Semi-Synthesis of Atypical Ubiquitin Chains and Ubiquitin-Based Probes Forged by Thioether Isopeptide Bonds | 期刊论文 | Chu Guo-Chao;Hua Xiao;Zuo Chong;Chen Chen-Chen;Meng Xian-Bin;Zhang Zhongping;Fu Yao;Shi Jing;Li Yi-Ming |
| 7 | Structural basis of human α7 nicotinic acetylcholine receptor activation | 期刊论文 | Zhao Yue;Liu Sanling;Zhou Yingxin;Zhang Mengge;Chen Haopeng;Eric Xu H;Sun Demeng;Liu Lei;Tian Changlin |
| 8 | Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit | 期刊论文 | Man Pan;Qingyun Zheng;Shuai Gao;Qian Qu;Yuanyuan Yu;Ming Wu;Huan Lan;Yulei Li;Sanling Liu;Jiabin Li;Demeng Sun;Lining Lu;Tian Wang;Wenhao Zhang;Jiawei Wang;Yiming Li;Hong-Gang Hu;Changlin Tian;Lei Liu |
| 9 | 镜像手性蛋白质研究进展 | 期刊论文 | 黎子琛;张宝昌;左冲;刘磊 |
| 10 | Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy | 期刊论文 | Qian Qu;Shuai Gao;Fangming Wu;Meng‐Ge Zhang;Ying Li;Long‐Hua Zhang;Donald Bierer;Chang‐Lin Tian;Ji‐Shen Zheng;Lei Liu |
| 11 | Chemical Synthesis of Six-Atom Thioether Bridged Diaminodiacid for Solid-Phase Synthesis of Peptide Disulfide Bond Mimics | 期刊论文 | Chen Junyou;Sun Shuaishuai;Zhao Rui;Xi Chen-Peng;Qiu Wenjie;Wang Ning;Wang Ya;Bierer Donald;Shi Jing;Li Yi-Ming |
| 12 | An E1-Catalyzed Chemoenzymatic Strategy to Isopeptide-N-Ethylated Deubiquitylase-Resistant Ubiquitin Probes | 期刊论文 | Zheng Qingyun;Wang Tian;Chu Guo-Chao;Zuo Chong;Zhao Rui;Sui Xin;Ye Linzhi;Yu Yuanyuan;Chen Jingnan;Wu Xiangwei;Zhang Wenhao;Deng Haiteng;Shi Jing;Pan Man;Li Yi-Ming;Liu Lei |
| 13 | Chemical Synthesis of Natural Polyubiquitin Chains through Auxiliary-Mediated Ligation of an Expressed Ubiquitin Isomer | 期刊论文 | Xu Ling;Huang Jian-Feng;Chen Chen-Chen;Qu Qian;Shi Jing;Pan Man;Li Yi-Ming |
| 14 | Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones | 期刊论文 | Chu Guo-Chao;Pan Man;Li Jiabin;Liu Sanlin;Zuo Chong;Tong Ze-Bin;Bai Jing-Si;Gong Qjngyue;Ai Huasong;Fan Jian;Meng Xianbin;Huang Yi-Chao;Shi Jing;Deng Haiteng;Tian Changlin;Li Yi-Ming;Liu Lei |
| 15 | Chemical synthesis of activity-based E2-ubiquitin probes for the structural analysis of E3 ligase-catalyzed transthiolation. | 期刊论文 | Lu‐Jun Liang;Guo‐Chao Chu;Qian Qu;Chong Zuo;Junxiong Mao;Qingyun Zheng;Jingnan Chen;Xianbin Meng;Yangwode Jing;Haiteng Deng;Yi‐Ming Li;Lei Liu |
| 16 | Mechanistic insight into substrate processing and allosteric inhibition of human p97 | 期刊论文 | Man Pan;Yuanyuan Yu;Qingyun Zheng;Minglei Zhao;Lei Liu;Huasong Ai;Yuan Xie |
| 17 | 多肽、提高多肽稳定性的方法、药物组合物以及多肽在制备药物中的用途 | 专利 | 刘磊;张林琦;郭叶;史宣玲 |
| 18 | A Novel d ‐Peptide Identified by Mirror‐Image Phage Display Blocks TIGIT/PVR for Cancer Immunotherapy | 期刊论文 | Xiuman Zhou;Chao Zuo;Wanqiong Li;Weiwei Shi;Xiaowen Zhou;Hongfei Wang;Shaomeng Chen;Jiangfeng Du;Guanyu Chen;Wenjie Zhai;Wenshan Zhao;Yahong Wu;Yuanming Qi;Lei Liu;Yanfeng Gao |
| 19 | Racemic crystal structures of peptide toxins, GsMTx4 prepared by protein total synthesis | 期刊论文 | Qu Qian;Gao Shuai;Li Yi-Ming |
| 20 | Development of Ubiquitin Tools for Studies of Complex Ubiquitin Processing Protein Machines | 期刊论文 | Sui Xin;Li Yi-Ming |
| 21 | Total Chemical Synthesis of Proteins | 专著 | Ashraf Brik;Philip Dowson;Lei Liu |
| 22 | An activity-based probe developed by a sequential dehydroalanine formation strategy targets HECT E3 ubiquitin ligases | 期刊论文 | Xu Ling;Fan Jian;Wang Yu;Zhang Zhongping;Fu Yao;Li Yi-Ming;Shi Jing |
| 23 | Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction | 期刊论文 | Huang Dong-Liang;Bai Jing-Si;Wu Meng;Wang Xia;Riedl Bernd;Pook Elisabeth;Alt Carsten;Erny Marion;Li Yi-Ming;Bierer Donald;Shi Jing;Fang Ge-Min |
| 24 | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1 | 期刊论文 | Sun Demeng;Liu Sanling;Li Siyu;Zhang Mengge;Yang Fan;Wen Ming;Shi Pan;Wang Tao;Pan Man;Chang Shenghai;Zhang Xing;Zhang Longhua;Tian Changlin;Liu Lei |
| 25 | 化合物及其制备方法和应用 | 专利 | 刘磊;潘漫;郑清芸;王天;曲倩 |
| 26 | 磷酸化对UCHL3体外去泛素化酶活性的影响 | 期刊论文 | 丁珊;任禹静;姜凌;梅子青 |
| 27 | 一种天然利那洛肽的结晶方法 | 专利 | 刘磊;陈晨晨;高帅;李宜明 |
| 28 | A Diaminodiacid (DADA) Strategy for the Development of Disulfide Surrogate Peptides | 期刊论文 | Qi Yun-Kun;Qu Qian;Bierer Donald;Liu Lei |
| 29 | Identification of interferon receptor IFNAR2 as a novel HCV entry factor by using chemical probes | 期刊论文 | Jie Qing;Ming Wu;Rui Luo;Jizheng Chen;Lin Cao;Debin Zeng;Luqing Shang;Junxiu Nong;Qinkai Wu;Bi-Sen Ding;Xinwen Chen;Zihe Rao;Lei Liu;Zhiyong Lou |
| 30 | Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling | 期刊论文 | Hua Xiao;Bai Jing-Si;Kong Yi-Fu;Chu Guo-Chao;Shi Jing;Li Yi-Ming |
| 31 | A mirror-image protein-based information barcoding and storage technology | 期刊论文 | Jun Liang;Wei-Wei Shi;Lei Liu;Hong-Gang Hu;Ji-Shen Zheng;Ying Li;Chang-Lin Tian |
| 32 | Chemical synthesis and racemic crystallization of rat C5a-desArg | 期刊论文 | Zuo Chao;Zhang Baochang;Wu Meng;Bierer Donald;Shi Jing;Fang Ge-Min |
| 33 | 一种环保型正交保护的二氨基二酸类化合物、其制备方法及其应用 | 专利 | 李宜明;白静思;王涛;许杨 |
| 34 | Structural insights into Ubr1-mediated N-degron polyubiquitination | 期刊论文 | Man Pan;Qingyun Zheng;Tian Wang;Lujun Liang;Junxiong Ma;Chong Zuo;Ruichao Ding;Huasong Ai;Yuan Xie;Dong Si;Yuanyuan Yu;Lei Liu;Minglei Zhao |
| 35 | Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy | 期刊论文 | Zuo Chao;Yan Bing-Jia;Zhu Han-Ying;Shi Wei-Wei;Xi Tong-Kuai;Shi Jing;Fang Ge-Min |
| 36 | A PROTAC peptide induces durable beta-catenin degradation and suppresses Wnt-dependent intestinal cancer | 期刊论文 | Liao Hongwei;Li Xiang;Zhao Lianzheng;Wang Yalong;Wang Xiaodan;Wu Ye;Zhou Xin;Fu Wei;Liu Lei;Hu Hong-Gang;Chen Ye-Guang |
| 37 | Synthesis of Peptide Disulfide-Bond Mimics by Using Fully Orthogonally Protected Diaminodiacids | 期刊论文 | Wang Tao;Fan Jian;Chen Xiao-Xu;Zhao Rui;Xu Yang;Bierer Donald;Liu Lei;Li Yi-Ming;Shi Jing;Fang Ge-Min |
| 38 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca~(2+)ions and L-tryptophan | 期刊论文 | Ling Shenglong;Shi Pan;Liu Sanling;Meng Xianyu;Zhou Yingxin;Sun Wenjing;Chang Shenghai;Zhang Xing;Zhang Longhua;Shi Chaowei;Sun Demeng;Liu Lei;Tian Changlin |
| 39 | Chemical Synthesis of Proteins Containing 300 Amino Acids | 期刊论文 | Zhang Baochang;Li Yulei;Shi Weiwei;Wang Tongyue;Zhang Feng;Liu Lei |
| 40 | The Ubiquitin Enigma: Progress in the Detection and Chemical Synthesis of Branched Ubiquitin Chains | 期刊论文 | Hua Xiao;Chu Guo-Chao;Li Yi-Ming |
| 41 | Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist | 期刊论文 | Zuo Chao;Shi Weiwei;Chen Xiaoxu;Glatz Marie;Riedl Bernd;Flamme Ingo;Pook Elisabeth;Wang Jiawei;Fang Gemin;Bierer Donald;Liu Lei |
| 42 | Development and application of ubiquitin-based chemical probes | 期刊论文 | Sui Xin;Wang Yu;Du Yun-Xiang;Liang Lu-Jun;Zheng Qingyun;Li Yi-Ming;Liu Lei |
| 43 | Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond | 期刊论文 | Zhao Rui;Shi Pan;Chen Junyou;Sun Shuaishuai;Chen Jingnan;Cui Jibin;Wu Fangming;Fang Gemin;Tian Changlin;Shi Jing;Bierer Donald;Liu Lei;Li Yi-Ming |
| 44 | Efficient synthesis of a side-chain extended diaminodiacid for solid-phase synthesis of peptide disulfide bond mimics | 期刊论文 | Sun Shuai-Shuai;Chen Junyou;Zhao Rui;Bierer Donald;Wang Jun;Fang Ge-Min;Li Yi-Ming |
| 45 | 化合物及其制备方法和应用 | 专利 | 刘磊;郑基深;左超;唐姗;田长麟 |
| 46 | Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents | 期刊论文 | Xu Yang;Wang Yu;Liu Peiyuan;Chu Guo-Chao;Xu Huajian;Li Yi-Ming;Wang Jun;Shi Jing |
| 47 | 一种用于二泛素合成的新型辅基连接臂及其合成方法和应用 | 专利 | 李宜明;陈俊佑;储国超 |
| 48 | K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle | 期刊论文 | Qingyun Zheng;Yuanyuan Yu;Man Pan;Seongjin Park;Satchal K. Erramilli;Minglei Zhao;Anthony A. Kossiakoff;Lei Liu;Jingxian Li;Jingyi Fei;Yuan Xie |
| 49 | Semi-synthesis of Ubiquitin-propargylamide for identifying deubiquitinase targeting inhibitors | 期刊论文 | Tan Xiaodan;Bai Jingsi;Ding Shan;Ren Yujing;Hong Danning;Mei Ziqing;Li Yi-Ming |
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