新型蛋白质甲基化、酰基化修饰的系统鉴定及其动态调控机制研究
91753203
2017
B0702.生物分子的化学生物学
李海涛
重大研究计划
教授
清华大学
300万元
分子机制;蛋白质翻译后修饰;动态调控;结构生物学;质谱分析
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种具有自动清洗功能的纳升液相系统及控制方法 | 专利 | 谭敏佳;翟琳辉;刘萍 |
| 2 | Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1 | 期刊论文 | Fan Zhao;Yunan Liu;Xiaonan Su;Ji-Eun Lee;Yutong Song;Daliang Wang;Kai Ge;Juntao Gao;Michael Q. Zhang;Haitao Li |
| 3 | Protein acetylation and butyrylation regulate the phenotype and metabolic shifts of the endospore-forming Clostridium acetobutylicum | 期刊论文 | Jun-Yu Xu;Zhen Xu;XinXin Liu;Minjia Tan;Bang-Ce Ye |
| 4 | The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L | 期刊论文 | Bing-bing Hao;Xiao-jing Li;Xing-long Jia;Yu-xing Wang;Lin-hui Zhai;Duan-zhuo Li;Jie Liu;Die Zhang;Yu-lu Chen;Yong-hu Xu;Sang-kyu Lee;Guo-feng Xu;Xiao-hua Chen;Yong-jun Dang;Bin Liu;Min-jia Tan |
| 5 | N6-methyladenine in DNA antagonizes SATB1 in early development | 期刊论文 | Zheng Li;Shuai Zhao;Raman V. Nelakanti;Kaixuan Lin;Tao P. Wu;Myles H. Alderman;Cheng Guo;Pengcheng Wang;Min Zhang;Wang Min;Zongliang Jiang;Yinsheng Wang;Haitao Li;Andrew Z. Xiao |
| 6 | Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity | 期刊论文 | Chih-Chao Hsu;Dan Zhao;Jiejun Shi;Danni Peng;Haipeng Guan;Yuanyuan Li;Yaling Huang;Hong Wen;Wei Li;Haitao Li;Xiaobing Shi |
| 7 | Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. | 期刊论文 | Zhao Shuai;Chuh Kelly N;Zhang Baichao;Dul Barbara E;Thompson Robert E;Farrelly Lorna A;Liu Xiaohui;Xu Ning;Xue Yi;Roeder Robert G;Maze Ian;Muir Tom W;Li Haitao |
| 8 | Beyond histone acetylation—writing and erasing histone acylations | 期刊论文 | Shuai Zhao;Xingrun Zhang;Haitao Li |
| 9 | Selective Targeting of AF9 YEATS Domain by Cyclopeptide Inhibitors with Preorganized Conformation. | 期刊论文 | Yixiang Jiang;Li Haitao;Guochao Chen;Xiao-Meng Li;Sha Liu;Gaofei Tian;Yuanyuan Li;Xin Li;Xiang David Li |
| 10 | Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution | 期刊论文 | Mengqing Gao;Jin Wang;Sophie Rousseaux;Minjia Tan;Lulu Pan;Lijun Peng;Sisi Wang;Wenqian Xu;Jiayi Ren;Yuanfang Liu;Martin Spinck;Sophie Barral;Tao Wang;Florent Chuffart;Ekaterina Bourova-Flin;Denis Puthier;Sandrine Curtet;Lisa Bargier;Zhongyi Cheng;Heinz Neumann;Jian Li;Yingming Zhao;Jian-Qing Mi;Saadi Khochbin |
| 11 | 丹参酮类化合物及其 用于治疗血管瘤的用途 | 专利 | 吴晔明;叶阳;武志祥;姚胜;蔡翊鸿;谭敏佳 |
| 12 | 一种色谱柱支架 | 专利 | 郭方;谭敏佳;翟琳辉;刘萍 |
| 13 | Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism | 期刊论文 | Jun-Yu Xu;Lei Zhao;Ying Xu;Bolin Li;Linhui Zhai;Minjia Tan;Bang-Ce Ye |
| 14 | Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins | 期刊论文 | Xiangle Ren;Yang Zhou;Zhaoyu Xue;Ning Hao;Yuanyuan Li;Xiaohuan Guo;Daliang Wang;Xiaobing Shi;Haitao Li |
| 15 | LysargiNase and Chemical Derivatization Based Strategy for Facilitating In-Depth Profiling of C-Terminome | 期刊论文 | Hao Hu;Wensi Zhao;Mengdi Zhu;Lei Zhao;Linhui Zhai;Jun-yu Xu;Ping Liu;Minjia Tan |
| 16 | Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14 | 期刊论文 | Shuangping Zheng;Yucong Bi;Haining Chen;Bo Gong;Shunji Jia;Haitao Li |
| 17 | DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing | 期刊论文 | Yufeng Li;Junyu Xu;Yuting Lu;Hua Bian;Lin Yang;Honghong Wu;Xinwen Zhang;Beilei Zhang;Maoqian Xiong;Yafei Chang;Jie Tang;Fan Yang;Lei Zhao;Jing Li;Xin Gao;Mingfeng Xia;Minjia Tan |
| 18 | MLN4924在缓解秋水仙碱中毒中的新用途 | 专利 | 谭敏佳;刘彬;翟琳辉 |
| 19 | Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis | 期刊论文 | Xu Jun Yu;Zhao Lei;Liu XinXin;Hu Hao;Liu Ping;Tan Minjia;Ye Bang Ce |
| 20 | Molecular basis for hierarchical histone de-beta-hydroxybutmlation by SIRT3 | 期刊论文 | Zhang Xingrun;Cao Ruili;Niu Jinrong;Yang Shumin;Ma Huida;Zhao Shuai;Li Haitao |
| 21 | Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered E. coli | 期刊论文 | Xu Jun Yu;Xu Ya;Chu Xiaohe;Tan Minjia;Ye Bang Ce |
| 22 | Mammalian ALKBH1 serves as an N~6-mA demethylase of unpairing DNA | 期刊论文 | Zhang Min;Yang Shumin;Nelakanti Raman;Zhao Wentao;Liu Gaochao;Li Zheng;Liu Xiaohui;Wu Tao;Xiao Andrew;Li Haitao |
| 23 | Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors | 期刊论文 | Huang Xun;Yan Juan;Zhang Min;Wang Yafang;Chen Yi;Fu Xuhong;Wei Rongrui;Zheng Xing-ling;Liu Zhiwei;Zhang Xiong;Yang Hong;Hao Bingbing;Shen Yan-yan;Su Yi;Cong Xiaoji;Huang Min;Tan Minjia;Ding Jian;Geng Meiyu |
| 24 | Integrative proteomic characterization of human lung adenocarcinoma. | 期刊论文 | Xu Jun-Yu;Zhang Chunchao;Wang Xiang;Zhai Linhui;Ma Yiming;Mao Yousheng;Qian Kun;Sun Changqing;Liu Zhiwei;Jiang Shangwen;Wang Minghui;Feng Lin;Zhao Lei;Liu Ping;Wang Bo;Zhao Xin;Xie Hui;Yang Xiaoyun;Zhao Liyuan;Chang Yafei;Jia Jingya;Wang Xijun;Zhang Yimin;Wang Yaru;Yang Yikun;Wu Zhixiang;Yang Longhai;Liu Bin;Zhao Teng;Ren Shengguo... |
| 25 | A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. | 期刊论文 | Zhiwei Liu;Yingluo Liu;Lili Qian;Shangwen Jiang;Xiameng Gai;Shu Ye;Yuehong Chen;Xiaomin Wang;Linhui Zhai;Jun Xu;Congying Pu;Jing Li;Fuchu He;Min Huang;Minjia Tan |
| 26 | Architecture of Saccharomyces cerevisiae SAGA complex | 期刊论文 | Gaochao Liu;Xiangdong Zheng;Haipeng Guan;Yong Cao;Hongyuan Qu;Junqing Kang;Xiangle Ren;Jianlin Lei;Meng-Qiu Dong;Xueming Li;Haitao Li |
| 27 | The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape | 期刊论文 | Daniel N.Weinberg;Simon Papillon-Cavanagh;Haifen Chen;Yuan Yue;Xiao Chen;Kartik N.Rajagopalan;Cynthia Horth;John T.McGuire;Xinjing Xu;Hamid Nikbakht;Agata E.Lemiesz;Dylan M.Marchione;Matthew R.Marunde;Matthew J.Meiners;Marcus A.Cheek;Michael-Christopher Keogh;Eric Bareke;Anissa Djedid;Ashot S.Harutyunyan;Nada Jabado;Benjamin A.Garcia;Haitao Li;C.David Allis;Jacek Majewski;Chao Lu |
| 28 | Molecular basis for SPIN·DOC-Spindlin1 engagement and its role in transcriptional inhibition | 期刊论文 | Fan Zhao;Fen Yang;Fan Feng;Bo Peng;Mark T. Bedford;Haitao Li1 |
| 29 | Molecular basis for histidine N1 position-specific methylation by CARNMT1. | 期刊论文 | Cao Ruili;Zhang Xingrun;Liu Xiaohui;Li Yuanyuan;Li Haitao |
| 30 | Comparative evaluation of label-free quantification strategies. | 期刊论文 | Lei Zhao;Xiaoji Cong;Linhui Zhai;Hao Hu;Jun-Yu Xu;Wensi Zhao;Mengdi Zhu;Minjia Tan;Bang-Ce Ye |
| 31 | Molecular basis for histidine N3-specific methylation of actin H73 by SETD3 | 期刊论文 | Yihui Zheng;Xingrun Zhang;Haitao Li |
| 32 | Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN | 期刊论文 | Liu Bin;Jiang Shangwen;Li Min;Xiong Xuelian;Zhu Mingrui;Li Duanzhuo;Zhao Lei;Qian Lili;Zhai Linhui;Li Jing;Lu Han;Sun Shengnan;Lin Jiandie;Lu Yan;Li Xiaoying;Tan Minjia |
| 33 | Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products | 期刊论文 | Jun-Yu Xu;Ya Xu;Zhen Xu;Lin-Hui Zhai;Yang Ye;Yingming Zhao;Xiaohe Chu;Minjia Tan;Bang-Ce Ye |
| 34 | Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. | 期刊论文 | Ping Liu;Xiaoji Cong;Shengjie Liao;Xinglong Jia;Xiaomin Wang;Wei Dai;Linhui Zhai;Lei Zhao;Jing Ji;Duan Ni;Zhiwei Liu;Yulu Chen;Lulu Pan;Wei Liu;Jian Zhang;Min Huang;Bin Liu;Minjia Tan |
| 35 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation | 期刊论文 | Shuai Zhao;Lingling Cheng;Yifei Gao;Baichao Zhang;Xiangdong Zheng;Liang Wang;Pilong Li;Qianwen Sun;Haitao Li |
| 36 | Histone H3.3 phosphorylation amplifies stimulation-induced transcription. | 期刊论文 | Armache Anja;Yang Shuang;Martínez de Paz Alexia;Robbins Lexi E;Durmaz Ceyda;Cheong Jin Q;Ravishankar Arjun;Daman Andrew W;Ahimovic Dughan J;Klevorn Thaís;Yue Yuan;Arslan Tanja;Lin Shu;Panchenko Tanya;Hrit Joel;Wang Miao;Thudium Samuel;Garcia Benjamin A;Korb Erica;Armache Karim-Jean;Rothbart Scott B;Hake Sandra B;Allis C David;Li Haitao;Josefowicz Steven Z |
| 37 | Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines | 期刊论文 | Bingbing Hao;Mingwei Sun;Min Zhang;Xiaoxiao Zhao;Lei Zhao;Bolin Li;Linhui Zhai;Ping Liu;Hao Hu;Jun-Yu Xu;Minjia Tan |
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