【81130066】基于整体观的中药复方(糖肾方)系统-系统的现代基础研究国家自然基金项目

基于整体观的中药复方(糖肾方)系统-系统的现代基础研究

项目批准号： 81130066

批准年份： 2011

学科分类： H32.中药学

项目负责人：罗国安

资助类别：重点项目

负责人职称：教授

依托单位：清华大学

资助金额： 240万元

关键词：作用机理;整体观;系统生物学;中药复方;系统-系统

起止时间： 2012-01-01到2016-12-31

中英文摘要
结题摘要
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序号	标题	类型	作者
1	Biomarkers for early diagnosis of type 2 diabetic nephropathy: a study based on an integrated biomarker system	期刊论文	Pang, Liqiong\|Han, Lida\|Wang, Yiming\|Luo, Guoan\|
2	中医药治疗糖尿病肾病合并血脂异常的Meta分析	期刊论文	刘鹏\|孔繁婧\|赵劼\|李平\|
3	糖尿病强化降糖治疗肾脏受益与相关风险	期刊论文	张并璇\|严美花\|赵海玲\|李平\|
4	Metabolomic and lipidomic study of the protective effect of Chaihuang-Yishen formula on rats with diabetic nephropathy	期刊论文	Lan Huiyao\|Liang Qionglin\|Luo Guoan\|Li Ping\|
5	Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Rats	期刊论文	Wen, YuMin\|Wang, Hua\|Lan, Hui Yao\|Li, Ping\|
6	Increased DNase I activity in diabetes might be associated with injury of pancreas	期刊论文	Pengmin Chen\|Haojun Zhang\|Tingting Zhao\|Ping Li\|
7	Urinary metabolomics study on an induced-stress rat model using UPLC-QTOF/MS	期刊论文	Zhang Huiyun\|Sun Peng\|Qiao Mingqi\|Luo Guoan\|
8	基于药代动力学和代谢组学研究咖啡因对异丙嗪镇静作用的影响	期刊论文	梁琼麟\|王义明\|白延强\|罗国安\|
9	Integrating qualitative and quantitative characterization of traditional Chinese medicine injection by high-performance liquid chromatography with diode array detection and tandem mass spectrometry	期刊论文	Qiaowei Wang\|Yiming Wang\|Qionglin Liang\|Guoan Luo\|
10	Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode	期刊论文	Xue-mei Fan\|Hong-Yang Zhang\|Qing-Li Zhang\|Guo-an Luo\|
11	Steaming-Induced Chemical Transformations and Holistic Quality Assessment of Red Ginseng Derived from Panax ginseng by Means of HPLC-ESI-MS/MSn-Based Multicomponent Quantification Fingerprint	期刊论文	Ma, Jin-fang\|Wang, Yi-ming\|Liang, Qiong-lin\|Luo, Guo-an\|
12	中医药发展亟需第二次思想解放—二论创建新医药学	期刊论文	梁琼麟\|王义明,\|谢媛媛\|范雪梅\|
13	The decreased expression of electron transfer flavoprotein beta is associated with tubular cell apoptosis in diabetic nephropathy	期刊论文	Sun, Sifan\|Lan, Hui-Yao\|Li, Ning\|Li, Ping\|
14	中西医结合治疗糖尿病肾病的“病证方效”研究	期刊论文	李平\|严美花\|文玉敏\|
15	Metabolism and pharmacokinetics of major polyphenol components in rat plasma after oral administration of total flavonoid tablet from Anemarrhenae Rhizoma	期刊论文	Yuan, Yong-sheng\|Li, Hong-yan\|Liang, Qiong-lin\|Luo, Guo-an\|
16	Efficacy and safety of tangshen formula on patients with type 2 diabetic kidney disease: a multicenter double-blinded randomized placebo-controlled trial	期刊论文	Li Ping\|
17	反相高效液相色谱法同时测定地黄中5 种成分的含量	期刊论文	谢媛媛\|王义明\|梁琼麟\|罗国安\|
18	益气活血法治疗糖尿病肾病显性蛋白尿的临床与基础研究.	奖励	张浩军\|赵婷婷\|李靖\|严美花\|
19	Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease: post-hoc findings from a multi-center, randomized, double-blind, placebo-controlled trial investigating the eff	期刊论文	Yan, Meihua\|Wen, Yumin\|Zhao, Tingting\|Li, Ping\|
20	中医药临床系统生物学研究体系与实践	期刊论文	范雪梅\|王义明\|陈万生\|罗国安\|
21	Evidence for the Involvement of JAK/STAT/SOCS Pathway in the Mechanism of Tangshen Formula-Treated Diabetic Nephropathy	期刊论文	Xiangsheng Meng\|Yiming Wang\|Qionglin Liang\|Guoan Luo\|
22	Renoprotective effect of berberine on type 2 diabetic nephropathy in rats	期刊论文	Wen Yumin\|Pan Xinping\|Lan Huiyao\|Li Ping\|
23	我们的中国梦:新医药学——四论创建新医药学	期刊论文	王义明\|梁琼麟\|谢媛媛\|范雪梅\|
24	Chinese herbal medicine Tangshen Formula treatment of patients with type 2 diabetic kidney disease with macroalbuminuria: study protocol for a randomized controlled trial	期刊论文	Lu, Xiaoguang\|Zhang, Bingxuan\|Huang, Weiping\|Li, Ping\|
25	丹参脂溶性成分抑制体外血管新生及机制研究	期刊论文	梁琼麟\|王文凯\|王义明\|罗国安\|
26	Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells	期刊论文	Zhu, Bin\|Han, Wenbing\|Wang, Hongpan\|Li, Ping\|
27	Screening and evaluation of traditional Chinese medicine by microarray expression analysis	期刊论文	Fan Xuemei\|Liang Qionglin\|Wang Yiming\|Luo Guoan\|
28	中医药整合医学—三论创建新医药学	期刊论文	谢媛媛\|梁琼麟\|范雪梅\|王义明\|
29	Systems Biology for Traditional Chinese Medicine	专著	罗国安\|
30	基于临床系统生物学的糖尿病肾病中医辨治研究与应用	奖励	付桂香\|路晓光\|杨丽平\|赵铁\|
31	糖肾方对db/db小鼠肾脏氧化损伤的保护作用	期刊论文	赵婷婷\|严美花\|赵海玲\|李平\|
32	Metabolomic and lipidomic study of the protective effect of Chaihuang-Yishen formula on rats with diabetic nephropathy	期刊论文	Lan Huiyao\|Liang Qionglin\|Luo Guoan\|Li Ping\|
33	Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode	期刊论文	Xue-mei Fan\|Hong-Yang Zhang\|Qing-Li Zhang\|Guo-an Luo\|

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