共价/非共价Polo-like Kinase 2抑制剂的设计、合成及其抗帕金森氏症的机理研究

21672050
2016
B0706.药物化学生物学
廖晨钟
面上项目
教授
合肥工业大学
65万元
药物设计;选择性抑制剂;Plk-2;药物合成;抗帕金森氏症
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors 期刊论文 Li Shiyu;Lv Xiao;Cheng Kai;Tian Yongbing;Huang Xufeng;Kong Haiyan;Duan Yajun;Han Jihong;Liao Chenzhong;Xie Zhouling
2 The selectivity and bioavailability improvement of novel oral anticoagulants: An overview 期刊论文 Xie Zhouling;Tian Yongbing;Lv Xiao;Xiao Xuan;Zhan Meimiao;Cheng Kai;Li Shiyu;Liao Chenzhong
3 精准靶向药物分子设计在药物发现中的应用 会议论文 廖晨钟
4 甲氨蝶呤缓释植入剂延迟小鼠肉瘤复发的研究 期刊论文 刘秀秀;高莉;夏伦洋;许健健;廖晨钟
5 Developments in inhibiting platelet aggregation based on different design strategies 期刊论文 Xie Zhouling;Tian Yongbin;Ma Lei;Lv Xiao;Cheng Kai;Li Shiyu;Huang Xufeng;Kong Haiyan;Huang Lei;Wu Bo;Liao Chenzhong
6 Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold 期刊论文 Zhan Mei Miao;Yang Yang;Luo Jinfeng;Zhang Xing Xing;Xiao Xuan;Li Shiyu;Cheng Kai;Xie Zhouling;Tu Zhengchao;Liao Chenzhong
7 Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold 期刊论文 Lv Xiao;Yang Xiaoxiao;Zhan Mei-Miao;Cao Peichang;Zheng Shihong;Peng Ruijun;Han Jihong;Xie Zhouling;Tu Zhengchao;Liao Chenzhong
8 一类新型二氢蝶啶酮类衍生物及其制备方法和在医药上的用途 专利 廖晨钟;杨洋;涂正超;张兴星;倪勇;郑敏;许涵菲;肖炫;詹美苗
9 Design, synthesis and evaluation of 1,4-benzodioxine derivatives as novel platelet aggregation inhibitors 期刊论文 Xie Zhouling;Zhao Lulu;Ding Xue;Kong Yi;Li Zhiyu
10 Progress in the Discovery of Macrocyclic Histone Deacetylase Inhibitors for the Treatment of Cancer 期刊论文 Cheng Kai;Li Siyu;Liao Chenzhong
11 Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors 期刊论文 Tian Yongbin;Xie Zhouling;Liao Chenzhong
12 Design, synthesis, and biological evaluation of novel highly selective Polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold 会议论文 詹美苗;肖炫;杨洋;谢周令;涂正超;廖晨钟
13 Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors 期刊论文 Lv Xiao;Tian Yongbing;Li Shiyu;Cheng Kai;Huang Xufeng;Kong Haiyan;Liao Chenzhong;Xie Zhouling
14 一种酞嗪衍生物及其制备方法和应用 专利 廖晨钟;田永彬;谢周令;吕笑
15 Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases 期刊论文 Xie Zhouling;Yang Xiaoxiao;Duan Yajun;Han Jihong;Liao Chenzhong
16 一种茚满类衍生物及其合成方法和在医药上的用途 专利 廖晨钟;张兴星;肖炫;詹美苗;马靖雯;朱蜜蜜;李银凤;管丽
17 Developing polo-like kinase 1 inhibitors 期刊论文 Huang Xufeng;Xie Zhouling;Liao Chenzhong
18 Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure 期刊论文 Cheng Kai;Li Shiyu;Lv Xiao;Tian Yongbin;Kong Haiyan;Huang Xufeng;Duan Yajun;Han Jihong;Xie Zhouling;Liao Chenzhong
19 Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline 期刊论文 Xiao Xuan;Zhang Xing Xing;Zhan Mei Miao;Cheng Kai;Li Shiyu;Xie Zhouling;Liao Chenzhong
20 Structure-based Design and SAR Development of Novel Selective Polo-Like Kinase 1 Inhibitors Having the Tetrahydropteridin Scaffold 会议论文 谢周令;廖晨钟
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