基于诱导多能干细胞和小鼠模型的重性抑郁症和双相抑郁症发病机制比较研究
31830038
2018
C0907.认知心理学
姚骏
重点项目
副教授
清华大学
274万元
动物模型;诱导多能干细胞;重性抑郁症;双相情感障碍;情感障碍
2019-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release | 期刊论文 | Si-Yao Lu;Chong-Lei Fu;Liang Liang;Bo Yang;Wei Shen;Qiu-Wen Wang;Yun Chen;Yan-Fen Chen;Yao-Nan Liu;Lin Zhu;Jieqing Zhao;Wei Shi;Shuangli Mi;Jun Yao |
| 2 | A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson’s disease mouse model | 期刊论文 | Chong-Lei Fu;Bo-Cheng Dong;Xi Jiang;Dan Li;Jun Yao |
| 3 | 16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin | 期刊论文 | Qiu-Wen Wang;Junhong Qin;Yan-Fen Chen;Yingfeng Tu;Yun-Yun Xing;Yuchen Wang;Lv-Yu Yang;Si-Yao Lu;Libo Geng;Wei Shi;Yiming Yang;Jun Yao |
| 4 | Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons | 期刊论文 | Yun Chen;Ying-Han Wang;Yi Zheng;Meijing Li;Bing Wang;Qiu-Wen Wang;Chong-Lei Fu;Yao-Nan Liu;Xueming Li;Jun Yao |
| 5 | Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. | 期刊论文 | Wang Qiu-Wen;Lu Si-Yao;Liu Yao-Nan;Chen Yun;Wei Hui;Shen Wei;Chen Yan-Fen;Fu Chong-Lei;Wang Ying-Han;Dai Anbang;Huang Xuan;Gage Fred H;Xu Qi;Yao Jun |
| 6 | Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice | 期刊论文 | Wei Shen;Qiu-Wen Wang;Yao-Nan Liu;Maria C. Marchetto;Sara Linker;Si-Yao Lu;Yun Chen;Chuihong Liu;Chongye Guo;Zhikai Xing;Wei Shi;John R. Kelsoe;Martin Alda;Hongwei Wang;Yi Zhong;Sen-Fang Sui;Mei Zhao;Yiming Yang;Shuangli Mi;Liping Cao;Fred H. Gage;Jun Yao |
| 7 | Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α | 期刊论文 | Yingfeng Tu;Jiao Qin;Qiao-Ming Zhang;Tie-Shan Tang;Lifang Wang;Jun Yao |
| 8 | Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants | 期刊论文 | Wang Qiu-Wen;Wang Ying-Han;Wang Bing;Chen Yun;Lu Si-Yao;Yao Jun |
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