定向纤维水凝胶递送多信号协同调控脊髓神经再生修复的研究
31771056
2017
C1003.组织工程学
王秀梅
面上项目
教授
清华大学
60万元
微环境;脊髓损伤;组织工程;神经再生;水凝胶
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种用于外周神经修复的仿生神经 移植物及其制备方法 | 专利 | 王秀梅;曹峥;杜金蓉;姚生莲 |
| 2 | 一种定向壳聚糖纤维水凝胶及其制备方法 | 专利 | 王秀梅;曹峥;姚生莲;隋佳洁 |
| 3 | Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair | 期刊论文 | He Yuzhu;Jin Yahui;Ying Xiaoxia;Wu Qiong;Yao Shenglian;Li Yuanyuan;Liu Huiying;Ma Guowu;Wang Xiumei |
| 4 | Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery. | 期刊论文 | Yang Shuhui;Zhu Jinjin;Lu Changfeng;Chai Yi;Cao Zheng;Lu Jiaju;Zhang Zhe;Zhao He;Huang Yin-Yuan;Yao Shenglian;Kong Xiangdong;Zhang Peixun;Wang Xiumei |
| 5 | Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats | 期刊论文 | Lu Jiaju;Guan Fengyi;Cui Fuzhai;Sun Xiaodan;Zhao Lingyun;Wang Ying;Wang Xiumei |
| 6 | Increased recruitment of endogenous stem cells and chondrogenic differentiation by a composite scaffold containing bone marrow homing peptide for cartilage regeneration | 期刊论文 | Lu Jiaju;Shen Xuezhen;Sun Xun;Yin Heyong;Yang Shuhui;Lu Changfeng;Wang Yu;Liu Yifan;Huang Yingqi;Yang Zijin;Dong Xianqi;Wang Chenhao;Guo Quanyi;Zhao Lingyun;Sun Xiaodan;Lu Shibi;Mikos Antonios G.;Peng Jiang;Wang Xiumei |
| 7 | Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release | 期刊论文 | Liu Zhu;Ye Weilong;Zheng Jingchuan;Wang Qindong;Ma Guowu;Liu Huiying;Wang Xiumei |
| 8 | Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration | 期刊论文 | Yang Shuhui;Wang Chong;Zhu Jinjin;Lu Changfeng;Li Haitao;Chen Fuyu;Lu Jiaju;Zhang Zhe;Yan Xiaoqing;Zhao He;Sun Xiaodan;Zhao Lingyun;Liang Jing;Wang Yu;Peng Jiang;Wang Xiumei |
| 9 | In Vitro Monolayer Culture of Dispersed Neural Stem Cells on the E-Cadherin-Based Substrate with Long-Term Stemness Maintenance | 期刊论文 | Yang Shuhui;Cao Zheng;Zhu Jinjin;Zhang Zhe;Zhao He;Zhao Lingyun;Sun Xiaodan;Wang Xiumei |
| 10 | Structural alignment guides oriented migration and differentiation of endogenous neural stem cells for neurogenesis in brain injury treatment. | 期刊论文 | Chai Yi;Zhao He;Yang Shuhui;Gao Xiaohan;Cao Zheng;Lu Jiaju;Sun Qingling;Liu Wei;Zhang Zhe;Yang Junyi;Wang Xuelin;Chen Tuoyu;Kong Xiangdong;Mikos Antonios G;Zhang Xiaohua;Zhang Yuqi;Wang Xiumei |
| 11 | Crosstalk between PC12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized self-assembling peptide nanofiber hydrogel | 期刊论文 | Zhang Zhe;Chai Yi;Zhao He;Yang Shuhui;Liu Wei;Yang Zihui;Ye Weilong;Wang Chenlong;Gao Xiaohan;Kong Xiangdong;Sun Xiaodan;Zhao Lingyun;Chen Tuoyu;Zhang Yuqi;Lu Jiaju;Wang Xiumei |
| 12 | White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury | 期刊论文 | Cao Zheng;Man Weitao;Xiong Yuhui;Guo Yi;Yang Shuhui;Liu Dongkang;Zhao He;Yang Yongdong;Yao Shenglian;Li Zhuzhong;Zhao Lingyun;Sun Xiaodan;Guo Hua;Wang Guihuai;Wang Xiumei |
| 13 | 一种神经导管及其制备方法 | 专利 | 王秀梅;王硕;段古满 |
| 14 | Bioactive Self-Assembling Peptide Hydrogels Functionalized with Brain-Derived Neurotrophic Factor and Nerve Growth Factor Mimicking Peptides Synergistically Promote Peripheral Nerve Regeneration | 期刊论文 | Lu Changfeng;Wang Yu;Yang Shuhui;Wang Chong;Sun Xun;Lu Jiaju;Yin Heyong;Jiang Wenli;Meng Haoye;Rao Feng;Wang Xiumei;Peng Jiang |
| 15 | Hierarchically aligned fibrin nanofiber hydrogel accelerated axonal regrowth and locomotor function recovery in rat spinal cord injury. | 期刊论文 | Yao Shenglian;Yu Shukui;Cao Zheng;Yang Yongdong;Yu Xing;Mao Hai-Quan;Wang Lu-Ning;Sun Xiaodan;Zhao Lingyun;Wang Xiumei |
| 16 | 一种复合神经导管及其制备方法 | 专利 | 王秀梅;赵勇刚 |
| 17 | Synergistic effects of dual-presenting VEGF- and BDNF-mimetic peptide epitopes from self-assembling peptide hydrogels on peripheral nerve regeneration | 期刊论文 | Lu Jiaju;Yan Xiaoqing;Sun Xun;Shen Xuezhen;Yin Heyong;Wang Chenhao;Liu Yifan;Lu Changfeng;Fu Haitao;Yang Shuhui;Wang Yu;Sun Xiaodan;Zhao Lingyun;Lu Shibi;Mikos Antonios G;Peng Jiang;Wang Xiumei |
| 18 | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525. | 期刊论文 | He Yuzhu;Li Yuanyuan;Zuo Enjun;Chai Songling;Ren Xiang;Fei Tao;Ma Guowu;Wang Xiumei;Liu Huiying |
| 19 | In Situ Articular Cartilage Regeneration through Endogenous Reparative Cell Homing Using a Functional Bone Marrow-Specific Scaffolding System. | 期刊论文 | Sun Xun;Yin Heyong;Wang Yu;Lu Jiaju;Shen Xuezhen;Lu Changfeng;Tang He;Meng Haoye;Yang Shuhui;Yu Wen;Zhu Yun;Guo Quanyi;Wang Aiyuan;Xu Wenjing;Liu Shuyun;Lu Shibi;Wang Xiumei;Peng Jiang |
| 20 | A multi-modal delivery strategy for spinal cord regeneration using a composite hydrogel presenting biophysical and biochemical cues synergistically | 期刊论文 | Man Weitao;Yang Shuhui;Cao Zheng;Lu Jiaju;Kong Xiangdong;Sun Xiaodan;Zhao Lingyun;Guo Yi;Yao Shenglian;Wang Guihuai;Wang Xiumei |
| 21 | Directional axonal regrowth induced by an aligned fibrin nanofiber hydrogel contributes to improved motor function recovery in canine L2 spinal cord injury | 期刊论文 | Cao Zheng;Yao Shenglian;Xiong Yuhui;Zhang Zhenxia;Yang Yongdong;He Feng;Zhao He;Guo Yi;Wang Guihuai;Xie Sheng;Guo Hua;Wang Xiumei |
| 22 | Mineralization of calcium phosphate controlled by biomimetic self-assembled peptide monolayers via surface electrostatic potentials | 期刊论文 | Wang Shuo;Yang Yongdong;Wang Ronghan;Kong Xiangdong;Wang Xiumei |
| 23 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration | 期刊论文 | Lu Jiaju;Sun Xun;Yin Heyong;Shen Xuezhen;Yang Shuhui;Wang Yu;Jiang Wenli;Sun Yue;Zhao Lingyun;Sun Xiaodan;Lu Shibi;Mikos Antonios G;Peng Jiang;Wang Xiumei |
| 24 | Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures | 期刊论文 | Zhu Jinjin;Yang Shuhui;Cai Kaiwen;Wang Shuo;Qiu Zhiye;Huang Junfei;Jiang Guoqiang;Wang Xiumei;Fang Xiangqian |
| 25 | 一种用于神经再生的定向纤维蛋白与多 肽互穿网络复合水凝胶及其制备方法 | 专利 | 王秀梅;曹峥;杨淑慧;杨嘉 |
| 26 | 两种新型功能化自组装多肽水凝胶的制备和体外研究 | 期刊论文 | 鲁长风;杨淑慧;王冲;杨轩;陈鹏;黄绍代;王玉;汪爱媛;林秋霞;许文静;卢世璧;彭江 |
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