【31270019】间充质干细胞作为多功能聚合物纳米粒子的载体用于肿瘤的靶向治疗国家自然基金项目

间充质干细胞作为多功能聚合物纳米粒子的载体用于肿瘤的靶向治疗

项目批准号： 31270019

批准年份： 2012

学科分类： C1002.生物材料与生物效应

项目负责人：梅林

资助类别：面上项目

负责人职称：教授

依托单位：清华大学

资助金额： 80万元

关键词：间充质干细胞;纳米粒子;肿瘤靶向;药物载体;共聚物

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
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序号	标题	类型	作者
1	DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer	期刊论文	Zeng Xiaowei\|Tao Wei\|Tsai Hsiang-i\|Mei Lin\|
2	BlackPhosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics	期刊论文	Wang, Xusheng\|Shi, Jinjun\|Zhang, Han\|Mei, Lin\|
3	Star-shaped block polymers as a molecular biomaterial for nanomedicine development	期刊论文	Mei, Lin\|Jiang, Yuyang\|Feng, Si-shen\|
4	Synthesis of cholic acid-core poly(epsilon-caprolactone-ran-lactide)-b-poly(ethylene glycol) 1000 random copolymer as a chemotherapeutic nanocarrier for liver cancer treatment	期刊论文	Gao, Yongfeng\|Tang, Jiao\|Huang, Laiqiang\|Mei, Lin\|
5	Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment	期刊论文	Shi, Xiaojun\|Tao, Wei\|Huang, Laiqiang\|Mei, Lin\|
6	Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells	期刊论文	Yang, Chengming\|Mei, Lin\|Wang, Zhongyuan\|Huang, Laiqiang\|
7	Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy.	期刊论文	Xiong, Qingqing\|Ouyang, Chunping\|Huang, Laiqiang\|Mei, Lin\|
8	Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress	期刊论文	Zhu, Xianbing\|Chang, Danfeng\|Zeng, Xiaowei\|Mei, Lin\|
9	Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer	期刊论文	Wang, Teng\|Zhang, Linhua\|Zeng, Xiaowei\|Mei, Lin\|
10	深圳市青年科技奖	奖励	梅林\|
11	A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity	期刊论文	Wang, Lijun\|Huang, Laiqiang\|He, Xiangjiu\|Mei, Lin\|
12	Autophagy inhibition strategy for advanced nanomedicine	期刊论文	Mei, Lin\|Zhang, Xudong\|Feng, Si-shen\|
13	Paclitaxel drug delivery systems	期刊论文	Zhang, Zhiping\|Mei, Lin\|Feng, Si-shen\|
14	Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance	期刊论文	Liu, Ranyi\|Cai, Lintao\|Mei, Lin\|Feng, Si-shen\|
15	pH-Triggered burst intracellular release from hollow microspheres to induce autophagic cancer cell death	期刊论文	Wu, Xiaojin\|Chen, Hongbo\|Zhang, Xudong\|Mei, Lin\|
16	Pharmaceutical nanotechnology for oral delivery of anticancer drugs	期刊论文	Huang, Laiqiang\|Yang, Xiang-Liang\|Tang, Jintian\|Feng, Si-Shen\|
17	Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma.	期刊论文	Liu, Xiaoyu\|Yu, Haiqiong\|Mei, Lin\|Liu, Zhigang\|
18	Porphine functionalized nanoparticles of star-shaped poly(epsilon-caprolactone)-b-D-alpha-tocopheryl polyethylene glycol 1000 succinate biodegradable copolymer for chemophotodynamic therapy on cervical cancer	期刊论文	Wang, Lijun\|Huang, Laiqiang\|Feng, Si-Shen\|Mei, Lin\|
19	Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer	期刊论文	Mei, Lin\|Huang, Laigiang\|Tan, Chunyan\|Feng, Si-Shen\|
20	Docetaxel-Loaded Nanoparticles of Dendritic Amphiphilic Block Copolymer H40-PLA-b-TPGS for Cancer Treatment	期刊论文	Jiang, Yuyang\|Huang, Laiqiang\|Mei, Lin\|Feng, Si-Shen\|
21	The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug	期刊论文	Chen, Hongbo\|Huang, Laiqiang\|Mei, Lin\|Feng, Si-Shen\|
22	Surface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapy	期刊论文	Xiao, Xiaojun\|Zhu, Yongqiang\|Gu, Dayong\|Mei, Lin\|
23	Doping effect of Al2O3 and CeO2 on Fe2O3 support for gold catalyst in CO oxidation at low-temperature	期刊论文	Zhen, Feng\|Zhang, Yuyan\|Mei, Lin\|Zeng, Xiaowei\|
24	Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects	期刊论文	Xudong Zhang\|Jinxie Zhang\|Gan Liu\|Lin Mei\|
25	The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo	期刊论文	Chang, Danfeng\|He, Shuai\|Mei, Lin\|Shi, Xiaojun\|
26	Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy	期刊论文	Liang, Xin\|Zhu, Xianbing\|Tao, Wei\|Mei, Lin\|
27	Investigation and intervention of autophagy to guide cancer treatment with nanogels	期刊论文	Liu Gan\|Zhang Yongjun\|Mei Lin\|Gu Zhen\|
28	功能性药用辅料及其在药物传递系统中的应用基础研究	奖励	黄来强\|曾小伟\|郑义\|陈红波\|
29	Nanotheranostics - Application and Further Development of Nanomedicine Strategies for Advanced Theranostics	期刊论文	Muthu, Madaswamy S.\|Leong, David Tai\|Mei, Lin\|Feng, Si-Shen\|
30	Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy	期刊论文	Liu, Yanlan\|Yu, Qingtong\|Huang, Laiqiang\|Mei, Lin\|
31	Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy	期刊论文	Tao, Wei\|Mei, Lin\|Huang, Laiqiang\|Zeng, Xiaowei\|
32	Antitumor Efficiency of D-alpha -Tocopheryl Polyethylene Glycol 1000 Succinate-b-Poly(epsilon-caprolactone-ran-lactide) Nanoparticle-Based Delivery of Docetaxel in Mice Bearing Cervical Cancer	期刊论文	Zhang, Jinxie\|Ming, Pinghong\|Huang, Laiqiang\|Mei, Lin\|
33	Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer	期刊论文	Xiao, Xiaojun\|Chen, Hongbo\|Huang, Laiqiang\|Mei, Lin\|
34	The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment.	期刊论文	Chen, Hongbo\|Jiang, Yuyang\|Mei, Lin\|Feng, Si-shen\|
35	Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma.	期刊论文	Liu, Xiaoyu\|Yu, Haiqiong\|Mei, Lin\|Liu, Zhigang\|
36	Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy	期刊论文	Tao, Wei\|Mei, Lin\|Huang, Laiqiang\|Zeng, Xiaowei\|

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