神经元来源外泌体中PPP2R5C蛋白在阿尔茨海默病发病机制中的作用研究
81971029
2019
H0902.意识障碍与认知功能障碍
沈璐
面上项目
教授
中南大学
55万元
tau蛋白;阿尔茨海默病;神经元来源外泌体;发病机制;PPP2R5C
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population | 期刊论文 | Xuewen Xiao;Bin Jiao;Xinxin Liao;Weiwei Zhang;Zhenhua Yuan;Lina Guo;Xin Wang;Lu Zhou;Xixi Liu;Xinxiang Yan;Beisha Tang;Lu Shen |
| 2 | The associations of APP , PSEN1 , and PSEN2 genes with Alzheimer's disease: A large case–control study in Chinese population | 期刊论文 | Xuewen Xiao;Hui Liu;Lu Zhou;Xixi Liu;Tianyan Xu;Yuan Zhu;Qijie Yang;Xiaoli Hao;Yingzi Liu;Weiwei Zhang;Yafang Zhou;Junling Wang;Jinchen Li;Bin Jiao;Lu Shen;Xinxin Liao |
| 3 | Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology | 期刊论文 | Bin Jiao;Rihui Li;Hui Zhou;Kunqiang Qing;Hui Liu;Hefu Pan;Yanqin Lei;Wenjin Fu;Xiaoan Wang;Xuewen Xiao;Xixi Liu;Qijie Yang;Xinxin Liao;Yafang Zhou;Liangjuan Fang;Yanbin Dong;Yuanhao Yang;Haiyan Jiang;Sha Huang;Lu Shen |
| 4 | Analyses Mutations in GSN, CST3, TTR, and ITM2B Genes in Chinese Patients With Alzheimer's Disease | 期刊论文 | Yaling Jiang;Bin Jiao;Xinxin Liao;Xuewen Xiao;Xixi Liu;Lu Shen |
| 5 | Clinical features of NOTCH2NLC-related neuronal intranuclear inclusion disease | 期刊论文 | Yun Tian;Lu Zhou;Jing Gao;Bin Jiao;Sizhe Zhang;Qiao Xiao;Jin Xue;Ying Wang;Hui liang;Yaling Liu;Guang Ji;Chenhui Mao;Caiyan Liu;Liling Dong;Long Zhang;Shugang Zhang;Jiping Yi;Guohua Zhao;Yingying Luo;Qiying Sun;Yafang Zhou;Fang Yi;Xiaoyu Chen;Chaojun Zhou;Nina Xie;Mengchuan Luo;Lingyan Yao;Yacen Hu;Mengqi Zhang;Qiuming Zeng;Liangjuan Fang;Hongyu Long;Yuanyuan Xie;Ling Weng;Si Chen;Juan Du;Qian Xu;Li Feng;Qing Huang... |
| 6 | The macular inner plexiform layer thickness as an early diagnostic indicator for Parkinson’s disease | 期刊论文 | Xin Wang;Bin Jiao;Xiaoliang Jia;Yaqin Wang;Hui Liu;Xiangyu Zhu;Xiaoli Hao;Yuan Zhu;Bei Xu;Sizhe Zhang;Qian Xu;Junling Wang;Jifeng Guo;Xinxiang Yan;Beisha Tang;Rongchang Zhao;Lu Shen |
| 7 | Associations of risk genes with onset age and plasma biomarkers of Alzheimer’s disease: a large case–control study in mainland China | 期刊论文 | Bin Jiao;Xuewen Xiao;Zhenhua Yuan;Lina Guo;Xinxin Liao;Yafang Zhou;Lu Zhou;Xin Wang;Xixi Liu;Hui Liu;Yaling Jiang;Zhuojie Lin;Yuan Zhu;Qijie Yang;Weiwei Zhang;Jinchen Li;Lu Shen |
| 8 | Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer’s disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations | 期刊论文 | Yingzi Liu;Xuewen Xiao;Hui Liu;Xinxin Liao;Yafang Zhou;Ling Weng;Lu Zhou;Xixi Liu;Xiang-yun Bi;Tianyan Xu;Yuan Zhu;Qijie Yang;Sizhe Zhang;Xiaoli Hao;Weiwei Zhang;Junling Wang;Bin Jiao;Lu Shen |
| 9 | CYLD. variants identified in Alzheimer's disease and frontotemporal dementia patients | 期刊论文 | Xuewen Xiao;Tianyan Xu;Hui Liu;Xixi Liu;Xinxin Liao;Yafang Zhou;Lu Zhou;Xin Wang;Yuan Zhu;Qijie Yang;Xiaoli Hao;Yingzi Liu;Hong Jiang;Jifeng Guo;Junling Wang;Beisha Tang;Jinchen Li;Lu Shen;Bin Jiao |
| 10 | A detection model for cognitive dysfunction based on volatile organic compounds from a large Chinese community cohort | 期刊论文 | Bin Jiao;Sizhe Zhang;Yuzhang Bei;Guiwen Bu;Li Yuan;Yuan Zhu;Qijie Yang;Tianyan Xu;Lu Zhou;Qianqian Liu;Ziyu Ouyang;Xuan Yang;Yong Feng;Beisha Tang;Haibin Chen;Lu Shen |
| 11 | The role of genetics in neurodegenerative dementia: a large cohort study in South China. | 期刊论文 | Bin Jiao;Hui Liu;Lina Guo;Xuewen Xiao;Xinxin Liao;Yafang Zhou;Ling Weng;Lu Zhou;Xin Wang;Yaling Jiang;Qijie Yang;Yuan Zhu;Lin Zhou;Weiwei Zhang;Junling Wang;Xinxiang Yan;Jinchen Li;Beisha Tang;Lu Shen |
| 12 | Association Between Serum Vitamins and the Risk of Alzheimer’s Disease in Chinese Population | 期刊论文 | Xixi Liu;Pengfei Wu;Yingzi Liu;Yaling Jiang;Meidan Wan;Xuewen Xiao;Qijie Yang;Bin Jiao;Xinxin Liao;Junling Wang;Shaohui Liu;Xuewei Zhang;Lu Shen |
| 13 | Genetics of progressive supranuclear palsy in a Chinese population | 期刊论文 | Xuewen Xiao;Qijie Yang;Yafei Wen;Bin Jiao;Xinxin Liao;Yafang Zhou;Ling Weng;Hui Liu;Tianyan Xu;Yuan Zhu;Lina Guo;Lu Zhou;Xin Wang;Xixi Liu;Xiangyun Bi;Yingzi Liu;Sizhe Zhang;Weiwei Zhang;Jinchen Li;Beisha Tang;Lu Shen |
| 14 | 遗传性痉挛性截瘫分子诊断规范流程的制定及应用 | 奖励 | 沈璐;杜鹃;佘鹏;王俊岭;唐北沙;严新翔 |
| 15 | Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population | 期刊论文 | Xinyue Zhang;Bin Jiao;Ling Weng;Yafang Zhou;Lina Guo;Xin Wang;Lu Zhou;Xixi Liu;Xuewen Xiao;Hui Liu;Xiangyu Zhu;Chenping Li;Yuan Zhu;Qijie Yang;Zhuojie Lin;Yaling Jiang;Yafei Wen;Hui Zhou;Lu Shen;Xinxin Liao |
| 16 | Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease | 期刊论文 | Xin Wang;Bin Jiao;Hui Liu;Yaqin Wang;Xiaoli Hao;Yuan Zhu;Bei Xu;Huizhuo Xu;Sizhe Zhang;Xiaoliang Jia;Qian Xu;Xinxin Liao;Yafang Zhou;Hong Jiang;Junling Wang;Jifeng Guo;Xinxiang Yan;Beisha Tang;Rongchang Zhao;Lu Shen |
| 17 | Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study | 期刊论文 | Ya-Fei Wen;Xue-Wen Xiao;Lu Zhou;Ya-Ling Jiang;Yuan Zhu;Li-Na Guo;Xin Wang;Hui Liu;Ya-Fang Zhou;Jun-Ling Wang;Xin-Xin Liao;Lu Shen;Bin Jiao |
| 18 | Associations of multiple visual rating scales based on structural magnetic resonance imaging with disease severity and cerebrospinal fluid biomarkers in patients with Alzheimer’s disease | 期刊论文 | Mei-dan Wan;Hui Liu;Xi-xi Liu;Wei-wei Zhang;Xue-wen Xiao;Si-zhe Zhang;Ya-ling Jiang;Hui Zhou;Xin-xin Liao;Yan-Jie Zhou;Bei-sha Tang;Jun-Ling Wang;Ji-feng Guo;Bin Jiao;Lu Shen |
| 19 | The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging | 期刊论文 | Yaling Jiang;Zhenxing Wang;Xixi Liu;Meidan Wan;Yiwei Liu;Bin Jiao;Xinxin Liao;Zhongwei Luo;Yiyi Wang;Chungu Hong;Yijuan Tan;Ling Weng;Yafang Zhou;Shanshan Rao;Jia Cao;Zhengzhao Liu;Tengfei Wan;Yuan Zhu;Hui Xie;Lu Shen |
| 20 | The role of frontotemporal dementia associated genes in patients with Alzheimer's disease | 期刊论文 | Xuewen Xiao;Zhenhua Yuan;Lina Guo;Xinxin Liao;Yafang Zhou;Weiwei Zhang;Lu Zhou;Xin Wang;Xixi Liu;Hui Liu;Junling Wang;Jinchen Li;Lu Shen;Bin Jiao |
| 21 | GSNgene frameshift mutations in Alzheimer’s disease | 期刊论文 | Yaling Jiang;Meidan Wan;XueWen Xiao;Zhuojie Lin;Xixi Liu;Yafang Zhou;Xinxin Liao;Jingyi Lin;Hui Zhou;Lu Zhou;Ling Weng;Junling Wang;Jifeng Guo;Hong Jiang;Zhuohua Zhang;Kun Xia;Jiada Li;Beisha Tang;Bin Jiao;Lu Shen |
| 22 | Specific serum autoantibodies predict the development and progression of Alzheimer’s disease with high accuracy | 期刊论文 | Liangjuan Fang;Bin Jiao;Xixi Liu;Zhenghong Wang;Peng Yuan;Hui Zhou;Xuewen Xiao;Liqin Cao;Jifeng Guo;Beisha Tang;Lu Shen |
| 23 | Association of rare variants in neurodegenerative genes with familial Alzheimer's disease | 期刊论文 | Weiwei Zhang;Bin Jiao;Tingting Xiao;Xixi Liu;Xinxin Liao;Xuewen Xiao;Lina Guo;Zhenhua Yuan;Xinxiang Yan;Beisha Tang;Lu Shen |
| 24 | Brain-derived extracellular vesicles promote bone-fat imbalance in Alzheimer's disease | 期刊论文 | Xixi Liu;Chunyuan Chen;Yaling Jiang;Meidan Wan;Bin Jiao;Xinxin Liao;Shanshan Rao;Chungu Hong;Qijie Yang;Yuan Zhu;Qianqian Liu;Zhongwei Luo;Ran Duan;Yiyi Wang;Yijuan Tan;Jia Cao;Zhengzhao Liu;Zhenxing Wang;Hui Xie;Lu Shen |
| 25 | Macular Microvascular Density as a Diagnostic Biomarker for Alzheimer’s Disease | 期刊论文 | Xin Wang;Yaqin Wang;Hui Liu;Xiangyu Zhu;Xiaoli Hao;Yuan Zhu;Bei Xu;Sizhe Zhang;Xiaoliang Jia;Ling Weng;Xinxin Liao;Yafang Zhou;Beisha Tang;Rongchang Zhao;Bin Jiao;Lu Shen |
| 26 | Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats | 期刊论文 | Bin Jiao;Mengli Wang;Hao Feng;Han Bao;Feiran Zhang;Hao Wu;Junling Wang;Beisha Tang;Peng Jin;Lu Shen |
| 27 | 用于阿尔茨海默症自身抗体检测的含JMJD2D蛋白片段的组合物 | 专利 | 沈璐;吴奇辉;殷堃;邹永红 |
| 28 | 用于阿尔茨海默症自身抗体检测的蛋白抗原组合及其应用 | 专利 | 邹永红;沈璐 |
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