衰老骨基质外泌体通过转运miR-483-5p抑制H型血管再生参与老年骨质疏松症发病
81871822
2018
H0608.骨、关节、软组织退行性病变
谢辉
面上项目
研究员
中南大学
57万元
微小RNA;H型血管;骨基质;外泌体;老年骨质疏松
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 树兰医学青年奖 | 奖励 | 谢辉 |
| 2 | 中华医学会骨质疏松和骨矿盐疾病中青年学术会议“刘士豪-朱宪彝”冠名优秀中青年研究者奖 | 奖励 | 谢辉 |
| 3 | Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox | 期刊论文 | Zhen-Xing Wang;Zhong-Wei Luo;Fu-Xing-Zi L;Jia Cao;Shan-Shan Rao;Yi-Wei Liu;Yi-Yi Wang;Guo-Qiang Zhu;Jiang-Shan Gong;Jing-Tao Zou;Qiang Wang;Yi-Juan Tan;Yan Zhang;Yin Hu;You-You Li;Hao Yin;Xiao-Kai Wang;Ze-Hui He;Lu Ren;Zheng-Zhao Liu;Xiong-Ke Hu;Ling-Qing Yuan;Ran Xu;Chun-Yuan Chen;Hui Xie |
| 4 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism | 期刊论文 | Hu Yin;Zhang Yan;Ni Chu-Yu;Chen Chun-Yuan;Rao Shan-Shan;Yin Hao;Huang Jie;Tan Yi-Juan;Wang Zhen-Xing;Cao Jia;Liu Zheng-Zhao;Xie Ping-Li;Wu Ben;Luo Juan;Xie Hui |
| 5 | Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice | 期刊论文 | Hu Yin;Xu Ran;Chen Chun-Yuan;Rao Shan-Shan;Xia Kun;Huang Jie;Yin Hao;Wang Zhen-Xing;Cao Jia;Liu Zheng-Zhao;Tan Yi-Juan;Luo Juan;Xie Hui |
| 6 | Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y | 期刊论文 | Yan Zhang;Chun-Yuan Chen;Yi-Wei Liu;Shan-Shan Rao;Yi-Juan Tan;Yu-Xuan Qian;Kun Xia;Jie Huang;Xi-Xi Liu;Chun-Gu Hong;Hao-Yin;Jia Cao;Shi-Kai Feng;Ze-Hui He;You-You Li;Zhong-Wei Luo;Ben Wu;Zi-Qi Yan;Tuan-Hui Chen;Meng-Lu Chen;Yi-Yi Wang;Zhen-Xing Wang;Zheng-Zhao Liu;Ming-Jie Luo;Xiong-Ke Hu;Ling Jin;Teng-Fei Wan;Tao Yue;Si-Yuan Tang;Hui Xie |
| 7 | Harmine targets inhibitor of DNA binding‐2 and activator protein‐1 to promote preosteoclast PDGF‐BB production | 期刊论文 | Jie Huang;You‐You Li;Kun Xia;Yi‐Yi Wang;Chun‐Yuan Chen;Meng‐Lu Chen;Jia Cao;Zheng‐Zhao Liu;Zhen‐Xing Wang;Hao Yin;Xiong‐Ke Hu;Zheng‐Guang Wang;Yong Zhou;Hui Xie |
| 8 | 动物主流烟雾全身暴露装置 | 专利 | 祝晟;谢辉;杜威;胡新月 |
| 9 | 一种双歧杆菌及其胞外囊泡在制备对抗高脂饮食导致的疾病的制剂中的应用 | 专利 | 谢辉;殷豪;陈春媛 |
| 10 | 2021年中华医学科技奖一等奖(骨关节退行性疾病治疗策略与关键技术创新和应用) | 奖励 | 雷光华;白晓春;曾超;谢辉;魏捷;贺新宁;蔡道章;黄敏军;张海严;杨原蘅;鄢博;高曙光;王伊伦;李辉;陈春媛 |
| 11 | Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3 | 期刊论文 | Zheng-Zhao Liu;Chun-Gu Hong;Wen-Bao Hu;Meng-Lu Chen;Ran Duan;Hong-Ming Li;Tao Yue;Jia Cao;Zhen-Xing Wang;Chun-Yuan Chen;Xiong-Ke Hu;Ben Wu;Haoming Liu;Yi-Juan Tan;Jiang-Hua Liu;Zhong-Wei Luo;Yan Zhang;Shan-Shan Rao;Ming-Jie Luo;Hao Yin;Yi-Yi Wang;Kun Xia;Lang Xu;Siyuan Tang;Ronggui Hu;Hui Xie |
| 12 | In vitro and in vivo osteogenesis up-regulated by two-dimensional nanosheets through a macrophage-mediated pathway | 期刊论文 | Haoming Liu;Gaojie Yang;Hao Yin;Zhen-Xing Wang;Chun-Yuan Chen;Zheng-Zhao Liu;Hui Xie |
| 13 | The Role of Autophagy in Osteoarthritis | 期刊论文 | Duan Ran;Xie Hui;Liu Zheng-Zhao |
| 14 | Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength | 期刊论文 | Liu Jiang-Hua;Chen Chun-Yuan;Liu Zheng-Zhao;Luo Zhong-Wei;Rao Shan-Shan;Jin Ling;Wan Teng-Fei;Yue Tao;Tan Yi-Juan;Yin Hao;Yang Fei;Huang Fei-Yu;Guo Jian;Wang Yi-Yi;Xia Kun;Cao Jia;Wang Zhen-Xing;Hong Chun-Gu;Luo Ming-Jie;Hu Xiong-Ke;Liu Yi-Wei;Du Wei;Luo Juan;Hu Yin;Zhang Yan;Huang Jie;Li Hong-Ming;Wu Ben;Liu Hao-Ming;Chen Tuan-Hui;Qian Yu-Xuan;Li You-You;Feng Shi-Kai;Chen Yang;Qi Lu-Yue... |
| 15 | 湖南省自然科学奖一等奖(骨质疏松症临床与发病机制研究) | 奖励 | 罗湘杭;谢辉;廖二元;李长俊;蒋铁建;鲁琼 |
| 16 | Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis | 期刊论文 | Chun-Yuan Chen;Shan-Shan Rao;Tao Yue;Yi-Juan Tan;Hao Yin;Ling-Jiao Chen;Ming-Jie Luo;Zun Wang;Yi-Yi Wang;Chun-Gu Hong;Yu-Xuan Qian;Ze-Hui He;Jiang-Hua Liu;Fei Yang;Fei-Yu Huang;Si-Yuan Tang;Hui Xie |
| 17 | Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation | 期刊论文 | Liu Jiang-Hua;Yue Tao;Luo Zhong-Wei;Cao Jia;Yan Zi-Qi;Jin Ling;Wan Teng-Fei;Shuai Ci-Jun;Wang Zheng-Guang;Zhou Yong;Xu Ran;Xie Hui |
| 18 | The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging | 期刊论文 | Ya-Ling Jiang;Zhen-Xing Wang;Xi-Xi Liu;Mei-Dan Wan;Yi-Wei Liu;Bin Jiao;Xin-Xin Liao;Zhong-Wei Luo;Yi-Yi Wang;Chun-Gu Hong;Yi-Juan Tan;Ling Weng;Ya-Fang Zhou;Shan-Shan Rao;Jia Cao;Zheng-Zhao Liu;Teng-Fei Wan;Yuan Zhu;Hui Xie;Lu Shen |
| 19 | 年轻骨细胞来源的细胞外囊泡的制备方法及其在制备治疗阿尔兹海默症药物中的应用 | 专利 | 沈璐;谢辉;江亚凌;王振兴;焦彬 |
| 20 | Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration | 期刊论文 | Luo Zhong-Wei;Li Fu-Xing-Zi;Liu Yi-Wei;Rao Shan-Shan;Yin Hao;Huang Jie;Chen Chun-Yuan;Hu Yin;Zhang Yan;Tan Yi-Juan;Yuan Ling-Qing;Chen Tuan-Hui;Liu Hao-Ming;Cao Jia;Liu Zheng-Zhao;Wang Zhen-Xing;Xie Hui |
| 21 | Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG | 期刊论文 | Chen Chun-Yuan;Rao Shan-Shan;Tan Yi-Juan;Luo Ming-Jie;Hu Xiong-Ke;Yin Hao;Huang Jie;Hu Yin;Luo Zhong-Wei;Liu Zheng-Zhao;Wang Zhen-Xing;Cao Jia;Liu Yi-Wei;Li Hong-Ming;Chen Yang;Du Wei;Liu Jiang-Hua;Zhang Yan;Chen Tuan-Hui;Liu Hao-Ming;Wu Ben;Yue Tao;Wang Yi-Yi;Xia Kun;Lei Peng-Fei;Tang Si-Yuan;Xie Hui |
| 22 | Extracellular vesicles from human urine-derived stem cells inhibit glucocorticoid-induced osteonecrosis of the femoral head by transporting and releasing pro-angiogenic DMBT1 and anti-apoptotic TIMP1 | 期刊论文 | Chen Chun-Yuan;Du Wei;Rao Shan-Shan;Tan Yi-Juan;Hu Xiong-Ke;Luo Ming-Jie;Ou Qi-Feng;Wu Pan-Feng;Qing Li-Ming;Cao Zhe-Ming;Yin Hao;Yue Tao;Zhan Chao-Hong;Huang Jie;Zhang Yan;Liu Yi-Wei;Wang Zhen-Xing;Liu Zheng-Zhao;Cao Jia;Liu Jiang-Hua;Hong Chun-Gu;He Ze-Hui;Yang Jun-Xiao;Tang Si-Yuan;Tang Ju-Yu;Xie Hui |
| 23 | H-type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing | 期刊论文 | Yan Zi-Qi;Wang Xiao-Kai;Zhou Yong;Wang Zheng-Guang;Wang Zhen-Xing;Jin Ling;Yin Hao;Xia Kun;Tan Yi-Juan;Feng Shi-Kai;Xie Ping-Li;Tang Si-Yuan;Fang Chang-Yun;Cao Jia;Xie Hui |
| 24 | 一种益生菌及其外膜囊泡在制备抗吸烟相关疾病制剂中的应用 | 专利 | 谢辉;胡新月;祝晟;王振兴 |
| 25 | 尿源干细胞外泌体在制备抗衰老制剂中的应用 | 专利 | 谢辉;陈春媛;饶珊珊;胡雄科;殷豪;王振兴 |
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