Gasdermin D介导内毒素血症相关心肌功能障碍的机制研究
81870171
2018
H0201.心脏结构、功能与发育异常
蔡菁菁
面上项目
研究员
中南大学
57万元
线粒体;心肌功能障碍;Gasdermin;炎症性半胱氨酸天冬氨酸特异性蛋白水解酶;内毒素血症;D
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women. | 期刊论文 | Yao Lu;Raimund Pechlaner;Jingjing Cai;Hong Yuan;Zhijun Huang;Guoping Yang;Jiangang Wang;Zhiheng Chen;Stefan Kiechl;Qingbo Xu |
| 2 | Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia. | 期刊论文 | Xuejing Sun;Junru Wu;Lun Liu;Yuanyuan Chen;Yan Tang;Suzhen Liu;Hang Chen;Youxiang Jiang;Yuanyuan Liu;Hong Yuan;Yao Lu;Zhaoyang Chen;Jingjing Cai |
| 3 | Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes | 期刊论文 | Xu Cheng;Ye-Mao Liu;Haomiao Li;Xin Zhang;Fang Lei;Juan-Juan Qin;Ze Chen;Ke-Qiong Deng;Lijin Lin;Ming-Ming Chen;Xiaohui Song;Meng Xia;Xuewei Huang;Weifang Liu;Jingjing Cai;Xiao-Jing Zhang;Feng Zhou;Peng Zhang;Yibin Wang;Xinliang Ma;Qingbo Xu;Juan Yang;Ping Ye;Weiming Mao;Xiaodong Huang;Jiahong Xia;Bing-Hong Zhang;Jiao Guo;Lihua Zhu;Zhibing Lu;Yufeng Yuan;Xiang Wei;Zhi-Gang She;Yan-Xiao Ji;Hongliang Li |
| 4 | Association of blood pressure in the first-week of hospitalization and long-term mortality in patients with acute left ventricular myocardial infarction. | 期刊论文 | Yan Tang;Suzhen Liu;Yunming Shi;Tian He;Xuejing Sun;Mingxing Wu;Zhiliu Peng;Fei Gui;Hong Yuan;Yao Lu;Jingjing Cai;Yuanyuan Chen |
| 5 | Effects of mechanical circulatory support devices in patients with acute myocardial infarction undergoing stent implantation: a systematic review and meta-analysis of randomised controlled trials. | 期刊论文 | Yunmin Shi;Yujie Wang;Xuejing Sun;Yan Tang;Mengqing Jiang;Yuanyuan Bai;Suzhen Liu;Weihong Jiang;Hong Yuan;Yao Lu;Jingjing Cai |
| 6 | 芙蓉学者奖励计划 | 奖励 | 蔡菁菁 |
| 7 | Nonalcoholic Fatty Liver Disease: An Emerging Driver of Hypertension | 期刊论文 | Yan-Ci Zhao;Guo-Jun Zhao;Ze Chen;Zhi-Gang She;Jingjing Cai;Hongliang Li |
| 8 | Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease. | 期刊论文 | Ze Chen;Yao Yu;Jingjing Cai;Hongliang Li |
| 9 | 长江学者青年学者 | 奖励 | 蔡菁菁 |
| 10 | Projection of global burden and risk factors for aortic aneurysm - timely warning for greater emphasis on managing blood pressure. | 期刊论文 | Xuewei Huang;Zhouxiang Wang;Zhengjun Shen;Fang Lei;Ye-Mao Liu;Ze Chen;Juan-Juan Qin;Hui Liu;Yan-Xiao Ji;Peng Zhang;Xiao-Jing Zhang;Juan Yang;Jingjing Cai;Zhi-Gang She;Hongliang Li |
| 11 | Global death burden and attributable risk factors of peripheral artery disease by age, sex, SDI regions, and countries from 1990 to 2030: Results from the Global Burden of Disease study 2019. | 期刊论文 | Weifang Liu;Chengzhang Yang;Ze Chen;Fang Lei;Juan-Juan Qin;Hui Liu;Yan-Xiao Ji;Peng Zhang;Jingjing Cai;Ye-Mao Liu;Zhi-Gang She;Xiao-Jing Zhang;Hongliang Li |
| 12 | Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. | 期刊论文 | Lihua Zhu;Zhi-Gang She;Xu Cheng;Juan-Juan Qin;Xiao-Jing Zhang;Jingjing Cai;Fang Lei;Haitao Wang;Jing Xie;Wenxin Wang;Haomiao Li;Peng Zhang;Xiaohui Song;Xi Chen;Mei Xiang;Chaozheng Zhang;Liangjie Bai;Da Xiang;Ming-Ming Chen;Yanqiong Liu;Youqin Yan;Mingyu Liu;Weiming Mao;Jinjing Zou;Liming Liu;Guohua Chen;Pengcheng Luo;Bing Xiao;Changjiang Zhang;Zixiong Zhang;Zhigang Lu;Junhai Wang;Haofeng Lu;Xigang Xia;Daihong Wang... |
| 13 | Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure | 期刊论文 | Yao Lu;Junru Wu;Wenduo Gu;Zhijun Huang;Zhihao Shu;Miao Huang;Jingyuan Chen;Mengli Zhou;Yuanyuan Bai;Xiang Chen;Yi Xiao;Minxue Shen;Dan Luo;Qihong Deng;Liyuan Chai;Meian He;Jicheng Gong;Hong Yuan;Qingbo Xu;Jingjing Cai |
| 14 | The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19. | 期刊论文 | Jingjing Cai;Haomiao Li;Changjiang Zhang;Ze Chen;Hui Liu;Fang Lei;Juan-Juan Qin;Ye-Mao Liu;Feng Zhou;Xiaohui Song;Jianghua Zhou;Yan-Ci Zhao;Bin Wu;Meiling He;Huilin Yang;Lihua Zhu;Peng Zhang;Yan-Xiao Ji;Guang-Nian Zhao;Zhigang Lu;Liming Liu;Weiming Mao;Xiaofeng Liao;Haofeng Lu;Daihong Wang;Xigang Xia;Xiaodong Huang;Xiang Wei;Jiahong Xia;Bing-Hong Zhang;Yufeng Yuan;Zhi-Gang She;Qingbo Xu;Xinliang Ma;Yibin Wang... |
| 15 | 线粒体氧化心磷脂作为靶点在筛选用于防治内毒血症相关性心功能障碍的制品中的应用 | 专利 | 蔡菁菁;唐艳;伍俊儒;孙雪菁;袁洪;陆瑶;石云敏;陈圆圆 |
| 16 | Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. | 期刊论文 | Ze Chen;Ruifeng Tian;Zhigang She;Jingjing Cai;Hongliang Li |
| 17 | 肾胺酶在心血管疾病中的作用与机制研究 | 奖励 | 蔡菁菁 |
| 18 | Nonalcoholic Fatty Liver Disease and Cardiac Remodeling Risk: Pathophysiological Mechanisms and Clinical Implications. | 期刊论文 | Jianghua Zhou;Lan Bai;Xiao-Jing Zhang;Hongliang Li;Jingjing Cai |
| 19 | Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling | 期刊论文 | Junyong Wang;Junpeng Ma;Hongyu Nie;Xiao-Jing Zhang;Peng Zhang;Zhi-Gang She;Hongliang Li;Yan-Xiao Ji;Jingjing Cai |
| 20 | Distributions and trends of the global burden of COPD attributable to risk factors by SDI, age, and sex from 1990 to 2019: a systematic analysis of GBD 2019 data. | 期刊论文 | Jiahua Zou;Tao Sun;Xiaohui Song;Ye-Mao Liu;Fang Lei;Ming-Ming Chen;Ze Chen;Peng Zhang;Yan-Xiao Ji;Xiao-Jing Zhang;Zhi-Gang She;Jingjing Cai;Yunman Luo;Ping Wang;Hongliang Li |
| 21 | Unexpected Rapid Increase in the Burden of NAFLD in China From 2008 to 2018: A Systematic Review and Meta-Analysis. | 期刊论文 | Feng Zhou;Jianghua Zhou;Wenxin Wang;Xiao-Jing Zhang;Yan-Xiao Ji;Peng Zhang;Zhi-Gang She;Lihua Zhu;Jingjing Cai;Hongliang Li |
| 22 | Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension | 期刊论文 | Sun X;Zhou M;Wen G;Huang Y;Wu J;Peng L;Jiang W;Yuan H;Lu Y;Cai J |
| 23 | Impact of Local Alloimmunity and Recipient Cells in Transplant Arteriosclerosis | 期刊论文 | Jingjing Cai;Jiacheng Deng;Wenduo Gu;Zhichao Ni;Yuanyuan Liu;Yogesh Kamra;Alka Saxena;Yanhua Hu;Hong Yuan;Qingzhong Xiao;Yao Lu;Qingbo Xu |
| 24 | Development and validation of a novel risk score to predict 5-year mortality in patients with acute myocardial infarction in China: a retrospective study. | 期刊论文 | Yan Tang;Yuanyuan Bai;Yuanyuan Chen;Xuejing Sun;Yunmin Shi;Tian He;Mengqing Jiang;Yujie Wang;Mingxing Wu;Zhiliu Peng;Suzhen Liu;Weihong Jiang;Yao Lu;Hong Yuan;Jingjing Cai |
| 25 | Epidemiological feature of NAFLD from 1999 to 2018 in China | 期刊论文 | Jianghua Zhou;Feng Zhou;Wenxin Wang;Xiao-Jing Zhang;Yan-Xiao Ji;Peng Zhang;Zhi-Gang She;Lihua Zhu;Jingjing Cai;Hongliang Li |
| 26 | 高血压风险评估与辅助决策关键技术研究及应用推广 | 奖励 | 蔡菁菁 |
| 27 | Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies. | 期刊论文 | Weiyi Qu;Tengfei Ma;Jingjing Cai;Xiaojing Zhang;Peng Zhang;Zhigang She;Feng Wan;Hongliang Li |
| 28 | 高血压风险评估与辅助决策关键技术研究及应用推广 | 奖励 | 袁洪;陈丰原;蔡菁菁;陆瑶;刘梅林;华琦;王馨;匡泽民 |
| 29 | Newly-Diagnosed Diabetes and Sustained Hyperglycemia are Associated with Poorer Outcomes in COVID-19 Inpatients Without Pre-Existing Diabetes. | 期刊论文 | Lijin Lin;Ze Chen;Ting Ding;Hui Liu;Feng Zhou;Xuewei Huang;Xingyuan Zhang;Weifang Liu;Bing-Hong Zhang;Yufeng Yuan;Peng Zhang;Xiao-Jing Zhang;Zhi-Gang She;Jingjing Cai;Wenping Chen;Hongliang Li |
| 30 | 镉损害人体早期健康的检测标志物及其筛选方法和用途 | 专利 | 袁洪;蔡菁菁;陆瑶 |
| 31 | Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism. | 期刊论文 | Yao Lu;Xuejing Sun;Liping Peng;Weihong Jiang;Wenbo Li;Hong Yuan;Jingjing Cai |
| 32 | NAFLD as a continuous driver in the whole spectrum of vascular disease. | 期刊论文 | Wei Li;Jiayi Liu;Jingjing Cai;Xiao-Jing Zhang;Peng Zhang;Zhi-Gang She;Shaoze Chen;Hongliang Li |
| 33 | Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis. | 期刊论文 | Mengqing Jiang;Xuejing Sun;Suzhen Liu;Yan Tang;Yunming Shi;Yuanyuan Bai;Yujie Wang;Qiong Yang;Qize Yang;Weihong Jiang;Hong Yuan;Qixia Jiang;Jingjing Cai |
| 34 | Kidney Function Indicators Predict Adverse Outcomes of COVID-19. | 期刊论文 | Ye-Mao Liu;Jing Xie;Ming-Ming Chen;Xiao Zhang;Xu Cheng;Haomiao Li;Feng Zhou;Juan-Juan Qin;Fang Lei;Ze Chen;Lijin Lin;Chengzhang Yang;Weiming Mao;Guohua Chen;Haofeng Lu;Xigang Xia;Daihong Wang;Xiaofeng Liao;Jun Yang;Xiaodong Huang;Bing-Hong Zhang;Yufeng Yuan;Jingjing Cai;Xiao-Jing Zhang;Yibin Wang;Xin Zhang;Zhi-Gang She;Hongliang Li |
| 35 | Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia. Circ Res. | 期刊论文 | Ze Chen;Jiayi Liu;Feng Zhou;Haomiao Li;Xiao-Jing Zhang;Zhi-Gang She;Zhibing Lu;Jingjing Cai;Hongliang Li |
| 36 | Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease. | 期刊论文 | Wenxin Wang;Manli Hu;Hui Liu;Xingyuan Zhang;Haomiao Li;Feng Zhou;Ye-Mao Liu;Fang Lei;Juan-Juan Qin;Yan-Ci Zhao;Ze Chen;Weifang Liu;Xiaohui Song;Xuewei Huang;Lihua Zhu;Yan-Xiao Ji;Peng Zhang;Xiao-Jing Zhang;Zhi-Gang She;Juan Yang;Hailong Yang;Jingjing Cai;Hongliang Li |
| 37 | Association between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study. | 期刊论文 | Huang Xue-Wei;Deng Ke-Qiong;Qin Juan-Juan;Lei Fang;Zhang Xing-Yuan;Wang Wen-Xin;Lin Lijin;Zheng Yu-Ming;Yao Dong-Ai;Lu Hui-Ming;Liu Feng;Chen Li-Dong;Zhang Gui-Lan;Liu Yue-Ping;Yang Qiong-Yu;Cai Jing-Jing;She Zhi-Gang;Li Hong-Liang |
| 38 | Nonalcoholic Fatty Liver Disease Pandemic Fuels the Upsurge in Cardiovascular Diseases. | 期刊论文 | Jingjing Cai;Xiao-Jing Zhang;Yan-Xiao Ji;Peng Zhang;Zhi-Gang She;Hongliang Li |
| 39 | High Remnant Cholesterol Level Potentiates the Development of Hypertension. | 期刊论文 | Ming-Ming Chen;Xuewei Huang;Chengsheng Xu;Xiao-Hui Song;Ye-Mao Liu;Dongai Yao;Huiming Lu;Gang Wang;Gui-Lan Zhang;Ze Chen;Tao Sun;Chengzhang Yang;Fang Lei;Juan-Juan Qin;Yan-Xiao Ji;Peng Zhang;Xiao-Jing Zhang;Lihua Zhu;Jingjing Cai;Feng Wan;Zhi-Gang She;Hongliang Li |
| 40 | Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19 [published correction appears in Circ Res | 期刊论文 | Peng Zhang;Lihua Zhu;Jingjing Cai;Fang Lei;Juan-Juan Qin;Jing Xie;Ye-Mao Liu;Yan-Ci Zhao;Xuewei Huang;Lijin Lin;Meng Xia;Ming-Ming Chen;Xu Cheng;Xiao Zhang;Deliang Guo;Yuanyuan Peng;Yan-Xiao Ji;Jing Chen;Zhi-Gang She;Yibin Wang;Qingbo Xu;Renfu Tan;Haitao Wang;Jun Lin;Pengcheng Luo;Shouzhi Fu;Hongbin Cai;Ping Ye;Bing Xiao;Weiming Mao;Liming Liu;Youqin Yan;Mingyu Liu;Manhua Chen;Xiao-Jing Zhang;Xinghuan Wang... |
| 41 | 急性心肌梗死患者5年内生存率的预测方法和系统 | 专利 | 蔡菁菁;袁洪;唐艳;白圆圆;陆瑶;孙雪菁;陈圆圆;石云敏 |
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