组织蛋白酶Cathepsin L促进BMPR2降解参与肺动脉高压内皮损伤的作用及机制

81773734
2017
H3502.心脑血管药物药理
李晓晖
面上项目
教授
中南大学
56万元
组织蛋白酶L;内皮损伤;肺动脉高压;骨形成蛋白受体2;蛋白降解
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种肺动脉压力检测装置 专利 李晓晖
2 Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression 期刊论文 Li Wen Qun;Tan Sheng Lan;Li Xiao Hui;Sun Tao Li;Li Dai;Du Jie;Wei Shan Shan;Li Yuan Jian;Zhang Bi Kui
3 Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway 期刊论文 Li Lijun;Yin Minghui;Hu Liqing;Tian Xiaoting;He Xiangrong;Zhao Congke;Li Ying;Li Qianbin;Li Xiaohui
4 Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats 期刊论文 Yuan-Yuan Cao;Hui-Xue Ba;Ying Li;Si-Yuan Tang;Zi-Qiang Luo;Xiao-Hui Li
5 一种小动物低氧培养仓 专利 李晓晖
6 Natural plant products in treatment of pulmonary arterial hypertension 期刊论文 Xiang Lili;Li Ying;Deng Xu;Kosanovic Djuro;Schermuly Ralph Theo;Li Xiaohui
7 Dendrobium candidum aqueous extract attenuates isoproterenol-induced cardiac hypertrophy through the ERK signalling pathway 期刊论文 Cao Yuan-Yuan;Li Ke;Li Ying;Tian Xiao-Ting;Ba Hui-Xue;Wang Aiping;Li Xiao-Hui
8 CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis. 期刊论文 Li Wenqun;Zhang Zheng;Li Xiaohui;Cai Jifeng;Li Dai;Du Jie;Zhang Bikui;Xiang Daxiong;Li Niansheng;Li Yuanjian
9 Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity 期刊论文 Wei Shanshan;Ma Wanjun;Li Xiaohui;Jiang Chuanhao;Sun Taoli;Li Yuanjian;Zhang Bikui;Li Wenqun
10 HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling 期刊论文 Wang Jin;Tian Xiao ting;Peng Zhouyf;Li Wen qun;Cao Yuan yuan;Li Ying;Li Xiao hui
11 An emerging strategy for targeted therapy of pulmonary arterial hypertension: Vasodilation plus vascular remodeling inhibition 期刊论文 Liqing Hu;Congke Zhao;Zhuo Chen;Gaoyun Hu;Xiaohui Li;Qianbin Li
12 炎症Caspase调控固有免疫在心血管疾病中的作用 期刊论文 盘冰洁;田晓婷;李晓晖
13 PKR deficiency alleviates pulmonary hypertension via inducing inflammasome adaptor ASC inactivation 期刊论文 Li Yapei;Li Ying;Li Lijun;Yin Minghui;Wang Jiangang;Li Xiaohui
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