簇集蛋白（Clusterin）介导的衰老相关分泌表型（SASP）在六价铬[Cr(VI)] 诱导的肝细胞恶性转化中的作用研究

81773478
2017
H3007.卫生毒理
肖芳
面上项目
教授
中南大学
45万元
簇集蛋白;六价铬;肝细胞;恶性转化;衰老相关分泌表型
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes. 期刊论文 Zhang Yujing;Bian Huanfeng;Ma Yu;Xiao Yuanyuan;Xiao Fang
2 Cr(VI)-Induced Autophagy Protects L-02 Hepatocytes from Apoptosis Through the ROS-AKT-mTOR Pathway 期刊论文 Liang Qi;Xiao Yuanyuan;Liu Kaihua;Zhong Caigao;Zeng Ming;Xiao Fang
3 Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca(2+)-ROS-Drp1-mitochondrial fission axis. 期刊论文 Tang Sixuan;Ye Shuzi;Ma Yu;Liang Yuehui;Liang NingJuan;Xiao Fang
4 Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity. 期刊论文 Zhang Yujing;Ma Yu;Xiao Yuanyuan;Lu Chan;Xiao Fang
5 Clusterin increases mitochondrial respiratory chain complex i activity and protects against hexavalent chromium-induced cytotoxicity in L-02 hepatocytes 期刊论文 Xiao Y;Zeng M;Yin L;Li N;Xiao F
6 Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium 期刊论文 Ma Yu;Liang Yuehui;Liang Ningjuan;Zhang Yujing;Xiao Fang
7 Blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes 期刊论文 Zhang Yujing;Ma Yu;Liang Ningjuan;Liang Yuehui;Lu Chan;Xiao Fang
8 The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence 期刊论文 Li Siwen;Ma Yu;Liang Yuehui;Liang Ningjuan;Ye Shuzi;Xiao Fang
9 Cellular and molecular mechanisms of xenobiotics-induced premature senescence. 期刊论文 Liang Yuehui;Liang Ningjuan;Yin Lirong;Xiao Fang
10 Comparison of several commonly used detection indicators of cell senescence. 期刊论文 Xiao Yuanyuan;Zhang Yiyuan;Xiao Fang
11 The role of IP3R-SOCCs in Cr(VI)-induced cytosolic Ca(2+)overload and apoptosis in L-02 hepatocytes 期刊论文 Liang Qi;Zhang Yujing;Zeng Ming;Guan Lan;Xiao Yuanyuan;Xiao Fang
12 Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes 期刊论文 Liang Ningjuan;Li Siwen;Liang Yuehui;Ma Yu;Tang Sixuan;Ye Shuzi;Xiao Fang
13 Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity. 期刊论文 Ma Yu;Zhang Yujing;Xiao Yuanyuan;Xiao Fang
14 Role of Clusterin/NF-kappa B in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes 期刊论文 Liang Yuehui;Liang Ningjuan;Ma Yu;Tang Sixuan;Ye Shuzi;Xiao Fang
15 Role of mitochondrial damage in Cr(VI)-induced endoplasmic reticulum stress in L-02 hepatocytes 期刊论文 Liang Qi;Zhang Yujing;Huang Manfeng;Xiao Yuanyuan;Xiao Fang
16 ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4. 期刊论文 Zhang Yujing;Xiao Yuanyuan;Ma Yu;Liang Ningjuan;Liang Yuehui;Lu Chan;Xiao Fang
17 衰老相关分泌表型对恶性肿瘤促进作用的研究进展 期刊论文 梁宁娟;肖芳
18 Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway 期刊论文 Ma Yu;Li Siwen;Ye Shuzi;Tang Sixuan;Hu Die;Wei Lai;Xiao Fang
19 Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway 期刊论文 Zhang Yujing;Zhang Yiyuan;Xiao Yuanyuan;Zhong Caigao;Xiao Fang
20 衰老相关分泌表型对恶性肿瘤的双向调节作用 期刊论文 梁月辉;肖芳
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