TREM-1/NLRP3炎症小体正反馈环路在ALI炎症级联反应中的作用
81670014
2016
H0102.呼吸系统感染、炎症与免疫
管茶香
面上项目
教授
中南大学
60万元
炎症级联反应;急性肺损伤;髓样细胞表达的触发受体-1;NLRP3炎症小体;正反馈
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence | 期刊论文 | Zhang Chen-Yu;Duan Jia-Xi;Yang Hui-Hui;Sun Chen-Chen;Zhong Wen-Jing;Tao Jia-Hao;Guan Xin-Xin;Jiang Hui-Ling;Hammock Bruce D.;Hwang Sung Hee;Zhou Yong;Guan Cha-Xiang |
| 2 | Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation | 期刊论文 | Liu Tian;Zhou Yong;Li Ping;Duan Jia Xi;Liu Yong Ping;Sun Guo Ying;Wan Li;Dong Liang;Fang Xiang;Jiang Jian Xin;Guan Cha Xiang |
| 3 | Vasoactive intestinal peptide overexpression mediated by lentivirus attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation | 期刊论文 | Sun Guo-Ying;Yang Hui-Hui;Guan Xin-Xin;Zhong Wen-Jing;Liu Yong-Ping;Du Ming-Yuan;Luo Xiao-Qin;Zhou Yong;Guan Cha-Xiang |
| 4 | Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on Myeloid Cells-1 by Inhibiting NF-kB Activation in Murine Macrophage | 期刊论文 | Dong Liang;Zhou Yong;Zhu Zhao-Qiong;Liu Tian;Duan Jia-Xi;Zhang Jun;Li Ping;Hammcok Bruce D.;Guan Cha-Xiang |
| 5 | Psoralen attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting myofibroblast activation and collagen deposition | 期刊论文 | Du Ming Yuan;Duan Jia Xi;Zhang Chen Yu;Yang Hui Hui;Guan Xin Xin;Zhong Wen Jing;Liu Yan Zhe;Li Zi Ming;Cheng Yu Rui;Zhou Yong;Guan Cha Xiang |
| 6 | Genomic Analysis Identifies Mutations Concerning Drug-Resistance and Beijing Genotype in Multidrug-ResistantMycobacterium tuberculosisIsolated From China | 期刊论文 | Wan Li;Liu Haican;Li Machao;Jiang Yi;Zhao Xiuqin;Liu Zhiguang;Wan Kanglin;Li Guilian;Guan Cha-xiang |
| 7 | A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress | 期刊论文 | Zhang Yan-Feng;Sun Chen-Chen;Duan Jia-Xi;Yang Hui-Hui;Zhang Chen-Yu;Xiong Jian-Bing;Zhong Wen-Jing;Zu Cheng;Guan Xin-Xin;Jiang Hui-Ling;Hammock Bruce D.;Hwang Sung Hee;Zhou Yong;Guan Cha-Xiang |
| 8 | Activation of NLRP3 inflammasome up-regulates TREM-1 expression in murine macrophages via HMGB1 and IL-18 | 期刊论文 | Zhong Wenjing;Duan Jiaxi;Liu Tian;Yang Huihui;Guan Xinxin;Zhang chenyu;Yang Jintong;Zhou Yong;Guan Chaxiang;Li Qing |
| 9 | PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice | 期刊论文 | Sun Chen-Chen;Zhang Chen-Yu;Duan Jia-Xi;Guan Xin-Xin;Yang Hui-Hui;Jiang Hui-Ling;Hammock Bruce D.;Hwang Sung Hee;Zhou Yong;Guan Cha-Xiang;Liu Shao-Kun;Zhang Jun |
| 10 | The role of NOX4 in pulmonary diseases | 期刊论文 | Li Zi-Ming;Xu Sheng-Ya;Feng Yi-Zhuo;Cheng Yu-Rui;Xiong Jian-Bing;Zhou Yong;Guan Cha-Xiang |
| 11 | A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation | 期刊论文 | Yang Hui-Hui;Duan Jia-Xi;Liu Shao-Kun;Xiong Jian-Bing;Guan Xin-Xin;Zhong Wen-Jing;Sun Chen-Chen;Zhang Chen-Yu;Luo Xiao-Qin;Zhang Yan-Feng;Chen Ping;Hammock Bruce D.;Hwang Sung Hee;Jiang Jian-Xin;Zhou Yong;Guan Cha-Xiang |
| 12 | VIP对LPS应激的小鼠成纤维细胞TREM-2表达的影响及其机制 | 期刊论文 | 李淑芬;宋卓慧;杨慧慧;刘永平;熊建兵;管茶香;孙国瑛 |
| 13 | Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells | 期刊论文 | Shao Min;Wen Zhi-Bin;Yang Hui-Hui;Zhang Chen-Yu;Xiong Jian-Bing;Guan Xin-Xin;Zhong Wen-Jing;Jiang Hui-Ling;Sun Chen-Chen;Luo Xiao-Qin;He Xiao-Fan;Zhou Yong;Guan Cha-Xiang |
| 14 | Aucubin Alleviates Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model | 期刊论文 | Zhou Yong;Li Ping;Duan Jia Xi;Liu Tian;Guan Xin Xin;Mei Wen Xiu;Liu Yong Ping;Sun Guo Ying;Wan Li;Zhong Wen Jing;Ouyang Dong Sheng;Guan Cha Xiang |
| 15 | Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice | 期刊论文 | Yong Zhou;Tian Liu;Jia-Xi Duan;Ping Li;Guo-Ying Sun;Yong Ping Liu;Jun Zhang;Liang Dong;Kin Sing Stephen Lee;Bruce D. Hammock;Jian-Xin Jiang;Cha-Xiang Guan |
| 16 | Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages | 期刊论文 | Luo Xiao-Qin;Duan Jia-Xi;Yang Hui-Hui;Zhang Chen-Yu;Sun Chen-Chen;Guan Xin-Xin;Xiong Jian-Bing;Zu Cheng;Tao Jia-Hao;Zhou Yong;Guan Cha-Xiang |
| 17 | Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model | 期刊论文 | Wen-Jing Zhong;Hui-Hui Yang;Xin-Xin Guan;Jian-Bing Xiong;Chen-Chen Sun;Chen-Yu Zhang;Xiao-Qin Luo;Yan-Feng Zhang;Jun Zhang;Jia-Xi Duan;Yong Zhou;Cha-Xiang Guan |
| 18 | Accuracy of a reverse dot blot hybridization assay for simultaneous detection of the resistance of four anti-tuberculosis drugs in Mycobacterium tuberculosis isolated from China | 期刊论文 | Wan Li;Guo Qian;Wei Jian-Hao;Liu Hai-Can;Li Ma-Chao;Jiang Yi;Zhao Li-Li;Zhao Xiu-Qin;Liu Zhi-Guang;Wan Kang-Lin;Li Gui-Lian;Guan Cha-Xiang |
| 19 | Vasoactive intestinal peptide inhibits the activation of murine fibroblasts and expression of interleukin 17 receptor C | 期刊论文 | Zhang Yan Feng;Zhang Jun;Sun Chen Chen;Tang Chun Yan;Sun Guo Ying;Luo Wan Jun;Zhou Yong;Guan Cha Xiang |
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