椎间盘退变中CK8介导的压力承载对髓核细胞命运及功能的调控研究
81730065
2017
H06.运动系统
罗卓荆
重点项目
教授
中国人民解放军第四军医大学
262万元
生物压力;椎间盘退变;髓核细胞;细胞凋亡;角蛋白8
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration | 期刊论文 | Pandi Peng;Dong Wang;Xiaolong Xu;Di Wang;Bo Gao;Han Wang;Haoruo Jia;Qiliang Shang;Chao Zheng;Chu Gao;Jianxin Mao;Zhuojing Luo;Liu Yang;Xueyu Hu |
| 2 | Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice | 期刊论文 | Bo Gao;Lin Xisheng;Huan Jing;Jing Fan;Chenchen Ji;Qiang Jie;Chao Zheng;Di Wang;Xiaolong Xu;Yaqian Hu;Weiguang Lu;Zhuojing Luo;Liu Yang |
| 3 | Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p | 期刊论文 | Bing Xia;Jianbo Gao;Shengyou Li;Liangliang Huang;Lei Zhu;Teng Ma;Laihe Zhao;Yujie Yang;Kai Luo;Xiaowei;Shi;Liangwei Mei;Hao Zhang;Yi Zheng;Lei Lu;Zhuojing Luo;Jinghui Huang |
| 4 | Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration | 期刊论文 | Dong Wang;Xin He;Chao Zheng;Chengzhe Wang;Pandi Peng;Chu Gao;Xiaolong Xu;Yachao Ma;Mei Liu;Liu Yang;Zhuojing Luo |
| 5 | Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration | 期刊论文 | Di Wang;Qiliang Shang;Jianxin Mao;Chu Gao;Jie Wang;Dong Wang;Han Wang;Haoruo Jia;Pandi Peng;Mu Du;Zhuojing Luo;Liu Yang |
| 6 | Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway | 期刊论文 | Dong Wang;Xin He;Di Wang;Pandi Peng;Xiaolong Xu;Bo Gao;Chao Zheng;Han Wang;Haoruo Jia;Qiliang Shang;Zhen Sun;Zhuojing Luo;Liu Yang |
| 7 | Epothilone B Facilitates Peripheral Nerve Regeneration by Promoting Autophagy and Migration in Schwann Cells | 期刊论文 | Zhou Jianhua;Li Shengyou;Gao Jianbo;Hu Yawei;Chen Shaochu;Luo Xinle;Zhang Hao;Luo Zhuojing;Huang Jinghui |
| 8 | Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias | 期刊论文 | Chao Zheng;Xisheng Lin;Xiaolong Xu;Cheng Wang;Jinru Zhou;Bo Gao;Jing Fan;Weiguang Lu;Yaqian Hu;Qiang Jie;Zhuojing Luo;Liu Yang |
| 9 | Magnetic Field Promotes Migration of Schwann Cells with Chondroitinase ABC (ChABC)-Loaded Superparamagnetic Nanoparticles Across Astrocyte Boundary in vitro | 期刊论文 | Jianbo Gao;Bing Xia;Shengyou Li;Liangliang Huang;Teng Ma;Xiaowei Shi;Kai Luo;Yujie Yang;Laihe Zhao;Hao Zhang;Beier Luo;Jinghui Huang |
| 10 | Cytokines CCL2 and CXCL1 may be potential novel predictors of early bone loss | 期刊论文 | Yaqian Hu;Long Wang;Zhuojie Zhao;Weiguang Lu;Jing Fan;Bo Gao;Zhuojing Luo;Qiang Jie;Xiaojuan Shi;Liu Yang |
| 11 | Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane | 期刊论文 | Xiaolong Xu;Di Wang;Chao Zheng;Bo Gao;Jing Fan;Pengzhen Cheng;Baohua Liu;Liu Yang;Zhuojing Luo |
| 12 | Leptin receptor–expressing cells represent a distinct subpopulation of notochord-derived cells and are essential for disc homoeostasis | 期刊论文 | Bo Gao;Jinhua Yin;Xiaolong Xu;Jing Fan;Di Wang;Chao Zheng;Weiguang Lu;Pengzhen Cheng;Jicheng Sun;Dong Wang;Lu Li;Bo O.Zhou;Liu Yang;Zhuojing Luo |
| 13 | SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis | 期刊论文 | Jianxin Mao;Di Wang;Dong Wang;Qi Wu;Qiliang Shang;Chu Gao;Huanbo Wang;Han Wang;Mu Du;Pandi Peng;Haoruo Jia;Xiaolong Xu;Jie Wang;Liu Yang;Zhuojing Luo |
| 14 | Hsa-let-7f-1-3p targeting the circadian gene Bmal1 mediates intervertebral disc degeneration by regulating autophagy | 期刊论文 | Liangwei Mei;Yi Zheng;Xue Gao;Teng Ma;Bing Xia;Yiming Hao;Bin Wei;Yitao Wei;Zhuojing Luo;Jinghui Huang |
| 15 | Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2 alpha arm of unfolded protein response and blocking autophagy | 期刊论文 | Wang Di;Zhang Peiran;Xu Xiaolong;Wang Jianhui;Wang Dong;Peng Pandi;Zheng Chao;Meng Qing-Jun;Yang Liu;Luo Zhuojing |
| 16 | Phenotypic characterization of. Slc26a2. mutant mice reveals a multifactorial etiology of spondylolysis | 期刊论文 | Chao Zheng;Xisheng Lin;He Liu;Weiguang Lu;Xiaolong Xu;Di Wang;Bo Gao;Cheng Wang;Jinru Zhou;Jing Fan;Yaqian Hu;Qiang Jie;Di Chen;Liu Yang;Zhuojing Luo |
| 17 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration | 期刊论文 | Dong Wang;Pandi Peng;Michal Dudek;Xueyu Hu;Xiaolong Xu;Qiliang Shang;Di Wang;Haoruo Jia;Han Wang;Bo Gao;Chao Zheng;Jianxin Mao;Chu Gao;Xin He;Pengzhen Cheng;Huanbo Wang;Jianmin Zheng;Judith A. Hoyland;Qing-Jun Meng;Zhuojing Luo;Liu Yang |
| 18 | Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration | 期刊论文 | Haoruo Jia;Xiao Lin;Dong Wang;Jingwei Wang;Qiliang Shang;Xin He;Kang Wu;Boyan Zhao;Pandi Peng;Han Wang;Di Wang;Pan Li;Liu Yang;Zhuojing Luo;Lei Yang |
| 19 | Decoding the annulus fibrosus cell atlas by scRNA-seq to develop an inducible composite hydrogel: A novel strategy for disc reconstruction | 期刊论文 | Han Wang;Di Wang;Beier Luo;Dong Wang;Haoruo Jia;Pandi Peng;Qiliang Shang;Jianxin Mao;Chu Gao;Ye Peng;Lu Gan;Junjie Du;Zhuojing Luo;Liu Yang |
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