支链氨基酸介导的能量代谢障碍在糖尿病心肌损伤中的作用及机制
81730011
2017
H02.循环系统
陶凌
重点项目
教授
中国人民解放军第四军医大学
295万元
支链氨基酸;丙酮酸脱氢酶;糖尿病;心肌能量代谢;心肌损伤
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through a beta-Catenin-Dependent Manner | 期刊论文 | Yan Wenjun;Lin Chen;Guo Yongzhen;Chen Youhu;Du Yunhui;Lau Wayne Bond;Xia Yunlong;Zhang Fuyang;Su Renzhi;Gao Erhe;Wang Yajing;Li Congye;Liu Rui;Ma Xin-liang;Tao Ling |
| 2 | Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation. | 期刊论文 | Zhang Xiaomeng;Xie Huaning;Chang Pan;Zhao Huishou;Xia Yunlong;Zhang Ling;Guo Xiong;Huang Chong;Yan Feng;Hu Lang;Lin Chen;Li Yueyang;Xiong Zhenyu;Wang Xiong;Li Guohua;Deng Longxiang;Wang Shan;Tao Ling |
| 3 | 中组部“万人计划”即科技部中青年科技创新领军人才 | 奖励 | 陶凌 |
| 4 | 缺血性心脏病心肌保护基础与临床研究团队-中国青年女科学家团队奖 | 奖励 | 陶凌;李飞;李妍;孙冬冬;张英梅;王海昌;易蔚;杨剑;闫文俊;马恒;孙阳;李嘉;葛伟;高好考;邢文娟 |
| 5 | FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin alpha V/beta 5-AKT signaling and reduction of oxidative/nitrosative stress | 期刊论文 | Lin Chen;Guo Yongzhen;Xia Yunlong;Li Congye;Xu Xiaoming;Qi Tingting;Zhang Fuyang;Fan Miaomiao;Hu Guangyu;Zhao Hang;Zhao Huishou;Liu Rui;Gao Erhe;Yan Wenjun;Tao Ling |
| 6 | 高危、复杂冠心病综合治疗策略的建立及应用 | 奖励 | 陶凌;王海昌;李成祥;孙冬冬;李伟杰;李飞;李妍;郭文怡;胡涛;刘毅;何争;刘兵;袁铭;易甫;王琼 |
| 7 | Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids | 期刊论文 | Yunlong Xia;Xinyue Xu;Yongzhen Guo;Chen Lin;Xiaoming Xu;Fuyang Zhang;Miaomiao Fan;Tingting Qi;Congye Li;Guangyu Hu;Lu Peng;Shan Wang;Ling Zhang;Chunxu Hai;Rui Liu;Wenjun Yan;Ling Tao |
| 8 | Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection | 期刊论文 | Hang Zhao;Xiyao Chen;Guangyu Hu;Congye Li;Lanyan Guo;Ling Zhang;Fangfang Sun;Yunlong Xia;Wenjun Yan;Ze Cui;Yongzhen Guo;Xiong Guo;Chong Huang;Miaomiao Fan;Shan Wang;Fuyang Zhang;Ling Tao |
| 9 | 一种转谷氨酰胺酶交联明胶的新用途 | 专利 | 陶凌;陈有虎;闫文俊;郭永珍;林晨 |
| 10 | Tailorable Hydrogel Improves Retention and Cardioprotection of Intramyocardial Transplanted Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice | 期刊论文 | Chen Youhu;Li Congye;Li Chengxiang;Chen Jiangwei;Li Yan;Xie Huaning;Lin Chen;Fan Miaomiao;Guo Yongzhen;Gao Erhe;Yan Wenjun;Tao Ling |
| 11 | TXNIP/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia/reperfusion injury in mice | 期刊论文 | Gao Chao;Wang Rutao;Li Bing;Guo Yongzhen;Yin Tao;Xia Yunlong;Zhang Fuyang;Lian Kun;Liu Yi;Wang Han;Zhang Ling;Gao Erhe;Yan Wenjun;Tao Ling |
| 12 | Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction | 期刊论文 | Fuyang Zhang;Guangyu Hu;Xiyao Chen;Ling Zhang;Lanyan Guo;Congye Li;Hang Zhao;Zhe Cui;Xiong Guo;Fangfang Sun;Dandan Song;Wenjun Yan;Yunlong Xia;Shan Wang;Miaomiao Fan;Ling Tao |
| 13 | Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation | 期刊论文 | Yueyang Li;Zhenyu Xiong;Wenjun Yan;Erhe Gao;Hexiang Cheng;Guiling Wu;Yi Liu;Ling Zhang;Congye Li;Shan Wang;Miaomiao Fan;Huishou Zhao;Fuyang Zhang;Ling Tao |
| 14 | Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling. | 期刊论文 | Zhao Huishou;Zhang Fuyang;Sun Dan;Wang Xiong;Zhang Xiaomeng;Zhang Jinglong;Yan Feng;Huang Chong;Xie Huaning;Lin Chen;Liu Yi;Fan Miaomiao;Yan Wenjun;Chen Youhu;Lian Kun;Li Yueyang;Zhang Ling;Wang Shan;Tao Ling |
| 15 | Resistin promotes cardiac homing of mesenchymal stem cells and functional recovery after myocardial ischemia/reperfusion via the ERK1/2-MMP-9 pathway | 期刊论文 | Yuan He;Yanjie Guo;Yunlong Xia;Yongzhen Guo;Rutao Wang;Fuyang Zhang;Lanyan Guo;Yi Liu;Tao Yin;Chao Gao;Erhe Gao;Congye Li;Shan Wang;Ling Zhang;Wenjun Yan;Ling Tao |
| 16 | Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction | 期刊论文 | Xia Yunlong;Zhang Fuyang;Zhao Shihao;Li Yueyang;Chen Xiyao;Gao Erhe;Xu Xinyue;Xiong Zhenyu;Zhang Xiaomeng;Zhang Jinglong;Zhao Huishou;Wang Wei;Wang Helin;Guo Yanjie;Liu Yi;Li Congye;Wang Shan;Zhang Ling;Yan Wenjun;Tao Ling |
| 17 | 树兰医学青年奖 | 奖励 | 陶凌 |
| 18 | Irisin Promotes Cardiac Homing of Intravenously Delivered MSCs and Protects against Ischemic Heart Injury. | 期刊论文 | Yan Wenjun;Chen Youhu;Guo Yongzhen;Xia Yunlong;Li Congye;Du Yunhui;Lin Chen;Xu Xiaoming;Qi Tingting;Fan Miaomiao;Zhang Fuyang;Hu Guangyu;Gao Erhe;Liu Rui;Hai Chunxu;Tao Ling |
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