HLA-E限制性多功能CD8+T细胞应答在汉滩病毒感染中的免疫保护及调节作用机制研究
81871239
2018
H1104.炎症、感染与免疫
马樱
面上项目
副教授
中国人民解放军第四军医大学
57万元
细胞应答;CD8+T;HLA-E;汉滩病毒;表位;免疫保护和免疫调节
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 褪黑素在感染性疾病中作用的研究进展 | 期刊论文 | 马焱;唐康;张春梅;张宇丝;张赟;金伯泉;马樱 |
| 2 | Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice | 期刊论文 | Ying Ma;Kang Tang;Yusi Zhang;Chunmei Zhang;Linfeng Cheng;Fanglin Zhang;Ran Zhuang;Boquan Jin;Yun Zhang |
| 3 | HTNV infection induces activation and deficiency of CD8 +MAIT cells in HFRS patients | 期刊论文 | Yusi Zhang;Meng Wang;Xiyue Zhang;Kang Tang;Chunmei Zhang;Xiaozhou Jia;Haifeng Hu;He Liu;Na Li;Ran Zhuang;Boquan Jin;Ying Ma;Yun Zhang |
| 4 | Elevated Plasma Fractalkine Level Is Associated with the Severity of Hemorrhagic Fever with Renal Syndrome in Humans | 期刊论文 | Chunmei Zhang;Kang Tang;Yusi Zhang;Ying Ma;Hong Du;Xuyang Zheng;Kun Yang;Lihua Chen;Ran Zhuang;Boquan Jin;Yun Zhang |
| 5 | Elevated Plasma Interleukin 34 Levels Correlate With Disease Severity-Reflecting Parameters of Patients With Haemorrhagic Fever With Renal Syndrome | 期刊论文 | Kang Tang;Chunmei Zhang;Yusi Zhang;Yun Zhang;Hong Du;Boquan Jin;Ying Ma |
| 6 | HLA-E限制性HTNV结构蛋白特异性CD8+T细胞表位肽及其聚合物和应用 | 专利 | 马樱;唐康;袁斌;庄然;张赟;张宇丝;张春梅;金伯泉 |
| 7 | Elevation of Myeloperoxidase Correlates with Disease Severity in Patients with Hantaan Virus Infection | 期刊论文 | Pengcheng Li;Chunmei Zhang;Meng Wang;Xiyue Zhang;Yusi Zhang;Kang Tang;Haifeng Hu;Xiaozhou Jia;Ran Zhuang;Boquan Jin;Ying Ma;Yun Zhang |
| 8 | Hantaan virus-induced elevation of plasma osteoprotegerin and its clinical implications in hemorrhagic fever with renal syndrome | 期刊论文 | Kang Tang;Yusi Zhang;Chunmei Zhang;Haifeng Hu;Ran Zhuang;Boquan Jin;Yun Zhang;Ying Ma |
| 9 | IL-15/ NKG2D轴参与CD8+T细胞旁路激活在病毒感染性疾病中的作用研究进展 | 期刊论文 | 张希越;王萌;张宇丝;唐康;张春梅;庄然;金伯泉;张赟;马樱 |
| 10 | 抗原特异性HLA-E限制性CD8+T细胞在感染性疾病中的作用 | 期刊论文 | 李昕瑜;马樱;唐康;刘晓斌;陈丽华 |
| 11 | Design and Synthesis of HLA-A02-restricted Hantaan Virus Multiple-Antigenic Peptide for CD8 + T Cells | 期刊论文 | Yan Ma;Kang Tang;Yusi Zhang;Chunmei Zhang;Yun Zhang;Boquan Jin;Ying Ma |
| 12 | Anti-platelet factor 4/heparin antibodies in patients with Hantaan virus infection | 期刊论文 | Meng Wang;Chunmei Zhang;Ying Ma;Kang Tang;Xiyue Zhang;Xiaozhou Jia;Haifeng Hu;Ran Zhuang;Boquan Jin;Yusi Zhang;Yun Zhang |
| 13 | The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome | 期刊论文 | Jingang Zhang;Kang Tang;Yun Zhang;Ying Ma;Chunmei Zhang;Haifeng Hu;Xiaozhou Jia;Ran Zhuang;Boquan Jin;Meng Wang;Xiyue Zhang;Dalu Liu;Yusi Zhang |
| 14 | Increased CD4+CD8+ Double Positive T Cells during Hantaan Virus Infection | 期刊论文 | Huiyuan Zhang;Yazhen Wang;Ying Ma;Kang Tang;Chunmei Zhang;Meng Wang;Xiyue Zhang;Manling Xue;Xiaozhou Jia;Haifeng Hu;Na Li;Ran Zhuang;Boquan Jin;Lihua Chen;Yun Zhang;Yusi Zhang |
| 15 | 一种HTNV抗原表位线性串联多肽及表位肽-复合物四聚体和应用 | 专利 | 马樱;张赟;袁斌;唐康;张宇丝;张春梅;方亮;陈丽华;杨琨;金伯泉 |
| 16 | IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection | 期刊论文 | Xiyue Zhang;Yusi Zhang;He Liu;Kang Tang;Chunmei Zhang;Meng Wang;Manling Xue;Xiaozhou Jia;Haifeng Hu;Na Li;Ran Zhuang;Boquan Jin;Fanglin Zhang;Yun Zhang;Ying Ma |
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