银屑病发病新机制——角蛋白17介导的免疫紊乱及其靶向治疗

81430073
2014
H12.皮肤病学
王刚
重点项目
主任医师
中国人民解放军第四军医大学
320万元
角质形成细胞;银屑病;T淋巴细胞;中性粒细胞;角蛋白17
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 银屑病免疫学研究热点与靶向治疗发展趋势 期刊论文 王刚;党二乐
2 含有白芍提取物的银屑病外用药及其制备方法 专利 王刚;俞晨;党二乐;薛柯;白小翠
3 银屑病调节性 T 细胞的功能异常及 STAT3通路调控机制研究 期刊论文 杨璐婷;李冰;张倩;党二乐;王刚
4 Mechanical Stretch Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production 期刊论文 Qiao Pei;Guo Wei;Ke Yao;Fang Hui;Zhuang Yuchen;Jiang Man;Zhang Jieyu;Shen Shengxian;Qiao Hongjiang;Dang Erle;Wang Gang
5 Up-regulation of Interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes 期刊论文 Cao Tianyu;Shao Shuai;Li Bing;Jin Liang;Lei Jie;Qiao Hongjiang;Wang Gang
6 Semaphorin4D Drives CD8(+) T-Cell Lesional Trafficking in Oral Lichen Planus via CXCL9/CXCL10 Upregulations in Oral Keratinocytes 期刊论文 Ke Yao;Dang Erle;Shen Shengxian;Zhang Tongmei;Qiao Hongjiang;Chang Yuqian;Liu Qing;Wang Gang
7 Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion 期刊论文 Shao Shuai;Cao Tianyu;Jin Liang;Li Bing;Fang Hui;Zhang Jieyu;Zhang Yuan;Hu Jinhong;Wang Gang
8 Ultrastructural characterization of hyperactive endothelial cells, pericytes and fibroblasts in hypertrophic and nodular port-wine stain lesions 期刊论文 Gao L.;Yin R.;Wang H.;Guo W.;Song W.;Nelson J. S.;Tan W.;Wang G.
9 Keratin 17 in disease pathogenesis: from cancer to dermatoses. 期刊论文 Yang Luting;Zhang Shaolong;Wang Gang
10 银屑病免疫学研究新进展 期刊论文 王刚
11 Mechanical stretch exacerbates psoriasis by promoting cell proliferation and amplifying pro-inflammatory effects of keratinocytes 会议论文 Qiao Pei;Dang Erle;Wang Gang
12 Autoantigen Keratin 17 presented by keratinocytes directs T cell auto-reactivity in psoriasis 会议论文 Dang Erle;Xiao Chunying;Wang Gang
13 Activation of PKC alpha and PI3K Kinases in Hypertrophic and Nodular Port Wine Stain Lesions 期刊论文 Yin Rong;Gao Lin;Tan Wenbin;Guo Wei;Zhao Tao;Nelson Jhon Stuart;Wang Gang
14 Neutrophil-derived exosome drives the autoinflammatory responses of generalized pustular psoriasis via activating NOD2 in keratinocytes 会议论文 Shao Shuai;Fang Hui;Dang Erle;Wang Gang
15 Effect of Calcipotriol on IFN-gamma-Induced Keratin 17 Expression in Immortalized Human Epidermal Keratinocyte Cells 期刊论文 Zhang Jieyu;Fang Hui;Wang Ruoyang;Dang Erle;Jiang Man;Wang Gang
16 Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes. 期刊论文 Shao Shuai;Fang Hui;Zhang Jingliang;Jiang Man;Xue Ke;Ma Jingyi;Zhang Jieyu;Lei Jie;Zhang Yangyang;Li Bing;Yuan Xu;Dang Erle;Wang Gang
17 TGF beta/SMAD/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis 期刊论文 Jiang Man;Sun Zhongbin;Dang Erle;Li Bing;Fang Hui;Li Junqin;Gao Lin;Zhang Kaiming;Wang Gang
18 Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3. 期刊论文 Luting Yang;Bing Li;Erle Dang;Liang Jin;Xueli Fan;Gang Wang
19 Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis 期刊论文 Jiang Man;Li Bing;Zhang Jieyu;Hu Lei;Dang Erle;Wang Gang
20 Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis. 期刊论文 Jiang Man;Fang Hui;Shao Shuai;Dang Erle;Zhang Jieyu;Qiao Pei;Yang Angang;Wang Gang
21 Proinflammatory effect of high-mobility group protein B1 onkeratinocytes: an autocrine mechanism underlying psoriasis development 期刊论文 Zhang Weigang;Guo Sen;Li Bing;Liu Lin;Ge Rui;Cao Tianyu;Wang Huina;Gao Tianwen;Wang Gang;Li Chunying
22 CD72low CD19+B subset associated with antibody production and corticosteroids resistance in bullous pemphigoid 会议论文 Shen Shengxian;Ke Yao;Fang Hui;Dang Erle;Zhang Jieyu;Qiao Hongjiang;Wang Gang
23 NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways. 期刊论文 Zhuang Yuchen;Han Changxu;Li Bing;Jin Liang;Dang Erle;Fang Hui;Qiao Hongjiang;Wang Gang
24 Neutrophil extracellular traps exacerbate the inflammation in psoriasis by inducing CXCL1/CXCL10 secretion in keratinocytes 会议论文 Shao Shuai;Fang Hui;Dang Erle;Wang Gang
25 Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk 期刊论文 Shao Shuai;Fang Hui;Dang Erle;Xue Ke;Zhang Jieyu;Li Bing;Qiao Hongjiang;Cao Tianyu;Zhuang Yuchen;Shen Shengxian;Zhang Tongmei;Qiao Pei;Li Caixia;Gudjonsson Johann E;Wang Gang
26 Topical Halometasone Reduces Acute Adverse Effects Induced by Pulsed Dye Laser for Treatment of Port Wine Stain Birthmarks. 期刊论文 Gao Lin;Qian Linhan;Wang Li;Li Kai;Yin Rong;Wang Yanting;Kang Hanmei;Song Wenting;Wang Gang
27 T cell epitopes of BPAG2 antigen and the epitope-based pathogenesis of bullous pemphigoid 会议论文 Zhang Jieyu;Fang Hui;Dang Erle;Li Qiuju;Wang Gang
28 CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-kappa B and the Inflammasome in Keratinocytes 期刊论文 Zhang Chen;Xiao Chunying;Dang Erle;Cao Jiao;Zhu Zhenlai;Fu Meng;Yao Xu;Liu Yufeng;Jin Boquan;Wang Gang;Li Wei
29 可抑制角蛋白17表达的SiRNA序列及应用 专利 王刚;党二乐;庄玉晨
30 Dysregulation of Akt-FOXO1 Pathway Leads to Dysfunction of Regulatory T Cells in Patients with Psoriasis 期刊论文 Li Bing;Lei Jie;Yang Luting;Gao Chao;Dang Erle;Cao Tianyu;Xue Ke;Zhuang Yuchen;Shao Shuai;Zhi Dalong;Hao Junfeng;Jin Liang;Qiao Pei;Ouyang Weiming;Wang Gang
31 Keratin 17 upregulate the expression of CXCL1 in human psoriastic keratinocyte cells through going the nucleus 会议论文 Luo Yixin;Zhu Zhenlai;Dang Erle;Wang Gang
32 Permanent alteration of Abcc6 with in vivo CRISPR-Cas9 genome editing 会议论文 Zhi Danglong;Dang Erle;Wang Gang
33 E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis. 期刊论文 Yang Luting;Jin Liang;Ke Yao;Fan Xueli;Zhang Tongmei;Zhang Chen;Bian Huijie;Wang Gang
34 Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17 期刊论文 Yang Luting;Fan Xueli;Cui Tingting;Dang Erle;Wang Gang
35 银屑病发病新机制及规范化治疗 奖励 王刚;李巍;付萌;晋亮;刘玉峰;王雷;李承新;沈柱;党二乐;高琳;常婷
36 MMP9-mediated Semaphorin4D shedding from T cells orchestrates chemokine secretion and CD8 + T cell migration in oral lichen planus 会议论文 Ke Yao;Shen Shengxian;Dang Erle;Zhang Tongmei;Qiao Hongjiang;Liu Qing;Wang Gang
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