【81170419】Notch信号通路在胎肝干/祖细胞自我更新和分化中的调控作用及其分子机制研究国家自然基金项目

Notch信号通路在胎肝干/祖细胞自我更新和分化中的调控作用及其分子机制研究

项目批准号： 81170419

批准年份： 2011

学科分类： H0311.肝保护和人工肝

项目负责人：陶开山

资助类别：面上项目

负责人职称：教授

依托单位：中国人民解放军第四军医大学

资助金额： 60万元

关键词： Notch信号;胎肝干/祖细胞;自我更新;分化方向;细胞治疗

起止时间： 2012-01-01到2015-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice	期刊论文	Zhang Hongtao\|Wang Desheng\|Tao Kaishan\|Dou Kefeng\|
2	Beneficial effects of splenectomy on liver regeneration in a rat model of massive hepatectomy	期刊论文	Liu, Wei-Hui\|Raut, Vikram\|Tao, Kai-Shan\|Dou, Ke-Feng\|
3	绿色荧光蛋白转基因小鼠胎肝干细胞在体内外定向分化的潜能	期刊论文	刘杰\|王兴\|郑志刚\|陶开山\|
4	肝移植与肝豆状核变性	期刊论文	张洪涛\|窦科峰\|陶开山\|李琳\|
5	Lumican Expression in Pancreatic Ductal Adenocarcinoma	期刊论文	Lu, Cheng-Yi\|Yang, Yan-Ling\|Dou, Ke-Feng\|Tao, Kai-Shan\|
6	肝癌干细胞研究进展	期刊论文	高远\|党立力\|刘卫辉\|窦科峰\|
7	Downregulation of miR-200a Induces EMT Phenotypes and CSC-like Signatures through Targeting the beta-catenin Pathway in Hepatic Oval Cells	期刊论文	Li, Xia\|Wang, Desheng\|Tao, Kaishan\|Dou, Kefeng\|
8	肝癌干细胞的研究进展	期刊论文	刘广欣\|党立力\|黄启科\|陶开山\|
9	Annexin A2 Promotes the Migration and Invasion of Human Hepatocellular Carcinoma Cells In Vitro by Regulating the Shedding of CD147-Harboring Microvesicles from Tumor Cells	期刊论文	Tao, Kai-Shan\|Zhou, Wen-Ping\|Chen, Zhi-Nan\|Dou, Ke-Feng\|
10	Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo	期刊论文	Wang, Xing\|Gong, Zhenbing\|Dou, Kefeng\|Tao, Kaishan\|
11	Notch is the key factor in the process of fetal liver stem/progenitor cells differentiation into hepatocytes	期刊论文	Li, Nanlin\|Tang, Lijun\|Liu, Weihui\|Dou, Kefeng\|
12	不同浓度HGF、EGF优化大鼠胎肝干细胞体外培养的研究	期刊论文	张宁\|王廷\|吕勇刚\|陶开山\|
13	Efficient Enrichment of Hepatic Cancer Stem-Like Cells from a Primary Rat HCC Model via a Density Gradient Centrifugation-Centered Method	期刊论文	Tao, Kai-shan\|Wang, Tao\|Tang, Li-jun\|Dou, Ke-feng\|
14	Unbalanced distribution of materials the art of giving rise to hepatocytes from liver stemprogenitor cells	期刊论文	Tao Wang\|Hong-Tao Yan\|Hao Luo\|Li-Jun Tang\|
15	Curcumin regulates hepatoma cell proliferation and apoptosis through the Notch signaling pathway	期刊论文	Huang, Qi-Ke\|Dang, Li-Li\|Liu, Guang-Xin\|Tao, Kai-Shan\|
16	不同浓度HGF、EGF优化大鼠胎肝干细胞体外培养的研究	期刊论文	张宁\|王廷\|吕勇刚\|陶开山\|
17	改良胰管空肠端侧吻合在胰十二指肠切除术中的应用	期刊论文	岳树强\|杨雁灵\|陶开山\|窦科峰\|
18	胎肝干细胞治疗终末期肝病的研究进展	期刊论文	陶开山\|
19	Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo	期刊论文	陶开山\|
20	Presence of FOXP3(+)Treg cells is correlated with colorectal cancer progression	期刊论文	Dang, Lili\|Chu, Dake\|Tao, Kaishan\|Wang, Weizhong\|
21	小分子干扰RNA介导的RhoA沉默优化胎肝干细胞培养	期刊论文	杨平\|寇明文\|张宁\|陶开山\|
22	High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma	期刊论文	Zhang, Hong-Tao\|Li, Jun\|Tao, Kai-Shan\|Xie, Bai-Zhi\|
23	Notch is the key factor in the process of fetal liver stem/progenitor cells differentiation into hepatocytes	期刊论文	陶开山\|
24	血清miR-21及AFP在大鼠肝癌发生过程中的动态表达比较分析	期刊论文	陶开山\|
25	Possibility of the Enhanced Progression of Fetal Liver Stem/Progenitor Cells Therapy for Treating End-stage Liver Diseases by Regulating the Notch Signaling Pathway	期刊论文	Liu, Weihui\|Zhong, Xiao\|Dou, Kefeng\|Tao, Kaishan\|
26	胎肝干细胞治疗终末期肝病的研究进展	期刊论文	尤楠\|刘卫辉\|窦科峰\|
27	一种大鼠肝癌干细胞的离心富集方法	期刊论文	陶开山\|
28	Neuroprotective Effects of Flax Lignan Against NMDA-Induced Neurotoxicity In Vitro	期刊论文	Wu, Yu-Mei\|Liu, Shui-Bing\|Tao, Kai-Shan\|Zhao, Ming-Gao\|
29	MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells	期刊论文	Lu, Cheng-Yi\|Yang, Yan-Ling\|Dou, Ke-Feng\|Tao, Kai-Shan\|
30	The possibility of the enhanced progression of fetal liver stem/progenitor cells therapy for treating end-stage liver diseases by regulating the Notch signaling pathway	期刊论文	刘卫辉\|钟晓\|窦科峰\|陶开山\|
31	Tg737基因参与胎肝干细胞正常分化的机制研究	期刊论文	李伟强\|张卓超\|窦科峰\|陶开山\|
32	Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest (vol 51, pg 659, 2012)	期刊论文	Zhang, Ming\|You, Houcheng\|Dou, Kefeng\|Tao, Kaishan\|
33	Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells	期刊论文	陶开山\|
34	Notch inhibition promotes fetal liver stem？progenitor cells differentiation into hepatocytes via the inhibition of HNF-1β	期刊论文	Zhu Huang\|Nan-lin Li\|Wei-hui Liu\|Li-jun Tang\|
35	大鼠门静脉分支残端置管模型构建及细胞移植途径的评价	期刊论文	黄启科\|周亮\|张福琴\|陶开山\|
36	RNA interference of GGTA1 physiological and immune functions in immortalized porcine aortic endothelial cells	期刊论文	Yang, Zhaoxu\|Wang, Desheng\|Tao, Kaishan\|Dou, Kefeng\|
37	Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest	期刊论文	Zhang, Ming\|You, Houcheng\|Dou, Kefeng\|Tao, Kaishan\|
38	several important in vitro improvements in the amplification, differentiation and tracing of fetal liver stem/progenitor cells	期刊论文	Tao Wang\|Zhen-bin Gong\|Hong-bao Liu\|Ke-feng Dou\|
39	Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway	期刊论文	Zheng, Zhigang\|You, Nan\|Dou, Kefeng\|Li, Haimin\|
40	小分子干扰RNA介导的RhoA沉默优化胎肝干细胞培养	期刊论文	杨平\|寇明文\|张宁\|陶开山\|
41	Efficient Enrichment of Hepatic Cancer Stem-Like Cells from a Primary Rat HCC Model via a Density Gradient Centrifugation-Centered Method	期刊论文	陶开山\|
42	低剂量LPS预处理的间充质干细胞对胰岛保护作用的研究	期刊论文	于泳\|王德盛\|陶开山\|窦科峰\|
43	Notch信号通路调控胎肝干/祖细胞治疗终末期肝病的研究进展	期刊论文	尤楠\|党立力\|刘广欣\|陶开山\|
44	异种肝移植现状与未来	期刊论文	李霄\|陶开山\|潘登科\|周亮\|
45	Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells	期刊论文	Wang, Desheng\|He, Yong\|Dou, Kefeng\|Tao, Kaishan\|
46	Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest (vol 51, pg 659, 2012)	期刊论文	Zhang, Ming\|You, Houcheng\|Dou, Kefeng\|Tao, Kaishan\|

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