内源甲醛通过特定miRs触发Aβ在不同脑区生成及沉积引起认知障碍生物学机制
82071214
2020
H0902.意识障碍与认知功能障碍
童志前
面上项目
研究员
北京老年医院
55万元
不同脑区;认知障碍;β-淀粉样蛋白;microRNAs;内源甲醛
2021-01-01到2024-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Tactile discrimination as a diagnostic indicator of cognitive decline in patients with mild cognitive impairment: A narrative review | 期刊论文 | Xu J;Sun Y;Zhu X;Pan S;Tong Z;Jiang K. |
| 2 | Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases | 期刊论文 | Jinan Xu;Xingjiang Jin;Zuting Ye;Dandan Wang;Hang Zhao;Zhiqian Tong |
| 3 | 阿尔茨海默病及相关痴呆的发生与早期诊治 | 奖励 | 贾建平;赫荣乔;贾龙飞;童志前;魏萃柏 |
| 4 | Neuropsychiatric Behavioral Assessments in Mice After Acute and Long-Term Treatments of Low-Intensity Pulsed Ultrasound | 期刊论文 | Ye Li;Yiqing Wu;Qi Luo;Xuanjie Ye;Jie Chen;Yuanlin Su;Ke Zhao;Xinmin Li;Jing Lin;Zhiqian Tong;Qi Wang;Dongwu Xu |
| 5 | Aβ-binding with alcohol dehydrogenase drives Alzheimer's disease pathogenesis: A review | 期刊论文 | Zuting Ye;Yanming Liu;Xingjiang Jin;Yiqing Wu;Hang Zhao;Tingting Gao;Qiangfeng Deng;Jianhua Cheng;Jing Lin;Zhiqian Tong |
| 6 | 脑细胞外间隙成像探测技术与应用 | 奖励 | 韩鸿宾;和清源;傅瑜;王伟;仇子龙;童志前;闫军浩;卢嘉宾 |
| 7 | Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives | 期刊论文 | Hang Zhao;Xuerong Huang;Zhiqian Tong |
| 8 | 一种虾青素脂质体及其制备方法和应用 | 专利 | 谷子琦;宋毅澜;黎翔;杨婉婷;丁翎;寇艺多;童志前 |
| 9 | Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice | 期刊论文 | Zhao Danrui;Wu Yiqing;Zhao Hang;Zhang Fengji;Wang Junting;Liu Yiying;Lin Jing;Huang Yirui;Pan Wenhao;Qi Jiahui;Chen Nan;Yang Xu;Xu Wen;Tong Zhiqian;Cheng Jianhua |
| 10 | PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde | 期刊论文 | Ziqi Gu;Hang Zhao;Yilan Song;Yiduo Kou;Wanting Yang;Ye Li;Xiang Li;Ling Ding;Zihui Sun;Jing Lin;Qi Wang;Xi Li;Xu Yang;Xuerong Huang;Chuang Yang;Zhiqian Tong |
| 11 | Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases | 期刊论文 | Zixi Tian;Kai Huang;Wanting Yang;Ying Chen;Wanjia Lyv;Beilei Zhu;Xu Yang;Ping Ma;Zhiqian Tong |
| 12 | Phototherapy for age-related brain diseases: Challenges, successes and future | 期刊论文 | Ling Ding;Ziqi Gu;Haishu Chen;Panpan Wang;Yilan Song;Xincheng Zhang;Mengyu Li;Jinhan Chen;Hongbin Han;Jianhua Cheng;Zhiqian Tong |
| 13 | Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes | 期刊论文 | Zhiqian Tong;Yun Zhang;Yufei Mei;Xiangpei Yue;Wenjing Jiang;Li Ai;Yan Yu;Hongjun Luo;Hui Li;Wenhong Luo;Xu Yang;Jihui Lyv;Rongqiao He;Weihong Song;Zhiqian Tong |
| 14 | Formaldehyde initiates memory and motor impairments under weightlessness condition | 期刊论文 | Tianhao Mei;Ying Chen;Yajuan Gao;Hang Zhao;Xingzhou Lyu;Jing Lin;Tianye Niu;Hongbin Han;Zhiqian Tong |
| 15 | Formic acid induces hypertension-related hemorrhage in hSSAOTG in mice and human. | 期刊论文 | Ya-lan Di;Yan Yu;Sheng-jie Zhao;Nayan Huang;Xue-chao Fei;Dan-dan Yao;Li Ai;Ji-hui Lyu;Rong-qiao He;Jian-jun Li;Zhi-qian Tong |
| 16 | 脑肿瘤细胞微环境体系“三室模型”创新理论与技术的精准诊疗应用 | 奖励 | 杨军;韩鸿宾;童志前 |
| 17 | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading | 期刊论文 | Dandan Yao;Qingyuan He;Shangying Bai;Hang Zhao;Jun Yang;Dehua Cui;Yan Yu;Xuechao Fei;Yufei Mei;Ye Cheng;Shi Yan;Nayan Huang;Yalan Di;Xianjie Cai;Rui Wang;Yajuan Gao;Fangxiao Cheng;Shengjie Zhao;Xu Yang;Xiang Cai;Hongbin Han;Jihui Lyu;Zhiqian Tong |
| 18 | Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity | 期刊论文 | Zixi Tian;Panpan Wang;Kai Huang;Jie Yu;Mange Zhang;Yanming Liu;Hang Zhao;Beilei Zhu;Xuerong Huang;Zhiqian Tong |
| 19 | Tropospheric formaldehyde levels infer ambient formaldehyde-induced brain diseases and global burden in China, 2013–2019 | 期刊论文 | Ye Yuan;Yiqing Wu;Hang Zhao;Jie Ren;Wenting Su;Yiduo Kou;Qi Wang;Jianhua Cheng;Zhiqian Tong |
| 20 | New Insights into Alzheimer's Disease: Novel Pathogenesis, Drug Target and Delivery | 期刊论文 | Chen H;Xu J;Xu H;Luo T;Li Y;Jiang K;Shentu Y;Tong Z. |
| 21 | Formaldehyde toxicity in age-related neurological dementia | 期刊论文 | Yiduo Kou;Hang Zhao;Dehua Cui;Hongbin Han;Zhiqian Tong |
| 22 | 一种光疗仪 | 专利 | 田梓希;黄凯;宇婕;张曼格;刘晏铭;朱蓓蕾;童志前 |
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