胃癌多药耐药相关分子群的网络调控及耐药标志与逆转剂筛选

30530780
2005
H18.肿瘤学
樊代明
重点项目
教授
中国人民解放军第四军医大学
160万元
逆转剂;胃癌;调控网络;多药耐药;RNA干涉
2006-01-01到2009-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis. 期刊论文
2 CIAPIN1 inhibits gastric cancer cell proliferation and cell cycle progression by downregulating CyclinD1 and upregulating P27. 期刊论文
3 KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells. 期刊论文
4 RhoC is essential for the metastasis of gastric cancer. 期刊论文
5 Inhibition of Osteopontin would suppress angiogenesis in gastric cancer. 期刊论文
6 Preparation and Characterization of a Specific Monoclonal Antibody Against a New Gene Product: URG11. 期刊论文
7 Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway. 期刊论文
8 Overexpression of PrP and Its Antiapoptosis Function in Gastric Cancer. 期刊论文
9 A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. 期刊论文
10 Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. 期刊论文
11 Zinc ribbon domain containing 1 protein: modulator of multidrug resistance, tumorigenesis and cell cycle. 期刊论文
12 Potent Inhibition of Human Gastric Cancer by HER2-directed Induction of Apoptosis with Anti-HER2 Antibody and Caspase-3 Fusion Protein. 期刊论文
13 Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp. 期刊论文
14 Identification and distribution of thioredoxin-like 2 as the antigen for the monoclonal antibody MC3 specific to colorectal cancer. 期刊论文
15 Upregulation of ZNRD1 Enhances Cisplatin Resistance in Human Esophageal Cancer Cells by Regulation of ERCC1 and Bcl-2. 期刊论文
16 Establishment and Characterization of Calcyclin Binding Protein (CacyBP) Monoclonal Antibody. 期刊论文
17 RUNX3 Inhibits Growth of HCC Cells and HCC Xenografts in Mice in Combination With Adriamycin. 期刊论文
18 Downregulated expression of CIAPIN1 may contribute to gastric carcinogenesis by accelerating cell proliferation and promoting cell cycle progression. 期刊论文
19 R-Flurbiprofen Reverses Multidrug Resistance, Proliferation and Metastasis in Gastric Cancer Cells by p75(NTR) Induction (dagger). 期刊论文
20 Up-regulation of tumor suppressor genes might promote the malignant phenotype of cancer cells. 期刊论文
21 Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC. 期刊论文
22 Hypoxia-inducible factor-1alpha contributes to hypoxia-induced chemoresistance in gastric cancer. 期刊论文
23 Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges. 期刊论文
24 p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells. 期刊论文
25 Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA. 期刊论文
26 Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. 期刊论文
27 Enhanced Cell Survival of Gastric Cancer Cells By a Novel Gene URG4. 期刊论文
28 A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy. 期刊论文
29 Subcellular Localization of CIAPIN1. 期刊论文
30 Mad2beta, an alternative variant of Mad2 reducing mitotic arrest and apoptosis induced by adriamycin in gastric cancer cells. 期刊论文
31 Differential expression of calcium-related genes in gastric cancer cells transfected with cellular prion protein. 期刊论文
32 Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. 期刊论文
33 Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells. 期刊论文
34 Detection of Serum Gastric Cancer-Associated MG7-Ag from Gastric Cancer Patients Using a Sensitive and Convenient ELISA Method. 期刊论文
35 Overexpression of a New Gene p28GANK Confers Multidrug Resistance of Gastric Cancer Cells. 期刊论文
36 Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC. 期刊论文
37 Expression and Prognostic Value of ZNRD1 in Esophageal Squamous Cell Carcinoma. 期刊论文
38 胃癌恶性表型相关分子群的发现及其序贯预防策略的建立和应用 奖励
39 MAD2 as a key component of mitotic checkpoint: a probable prognostic factor of gastric cancer. 期刊论文
40 肿瘤研究前沿（第7卷） 专著
41 KCl Depolarization Increases HIF-1 Transcriptional Activity via the Calcium-Independent Pathway in SGC7901 Gastric Cancer Cells. 期刊论文
42 ZNRD1 might mediate UV irradiation related DNA damage and repair in human esophageal cancer cells by regulation of ERCC1. 期刊论文
43 CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells. 期刊论文
44 Akt1/protein Kinase Balpha is Involved in Gastric Cancer Progression and Cell Proliferation. 期刊论文
45 EpCAM: A Potential Antimetastatic Target for Gastric Cancer. 期刊论文
46 Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer. 期刊论文
47 Reduction of TIP30 correlates with poor prognosis of gastric cancer patients and its restoration drastically inhibits tumor growth and metastasis. 期刊论文
48 URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. 期刊论文
49 Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. 期刊论文
50 Human ribosomal protein S13 promotes gastric cancer growth through downregulating p27(Kip1). 期刊论文
51 RhoE enhances multidrug resistance of gastric cancer cells by suppressing Bax. 期刊论文
52 TRF2 Promotes Multidrug Resistance in Gastric Cancer Cells. 期刊论文
53 Function of PrP(C)(1-OPRD) in biological activities of gastric cancer cell lines. 期刊论文
54 Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. 期刊论文
55 Hypoxia Induced Overexpression of PrP(C) in Gastric Cancer Cell Lines. 期刊论文
56 Identification of GAS1 as an epirubicin resistance related gene in human gastric cancer cells with a partially randomized siRNA library. 期刊论文
57 CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. 期刊论文
58 Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential. 期刊论文
59 URG11 Promotes Gastric Cancer Growth and Invasion by Activation of beta-Catenin Signaling Pathway. 期刊论文
60 Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. 期刊论文
61 肿瘤耐药相关基因数据库DREGET 期刊论文
62 胃癌细胞多药耐药性分子机制研究 奖励
63 Molecular basis of therapeutic approaches to gastric cancer. 期刊论文
64 Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. 期刊论文
65 Role of Racl and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. 期刊论文
66 Distribution of CIAPIN1 in Normal Fetal and Adult Human Tissues. 期刊论文
67 RUNX3 directly Interacts with Intracellular Domain of Notch1 and Suppresses Notch Signaling in Hepatocellular Carcinoma Cells. 期刊论文
68 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. 期刊论文
69 DARPP-32 Mediates Multidrug Resistance of Gastric Cancer Through Regulation of P-gp and ZNRD1. 期刊论文
70 Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. 期刊论文
71 Expression and significance of TWIST basic helix-loop-helix protein overexpression in gastric cancer. 期刊论文
72 Expression and significance of HERG protein in gastric cancer. 期刊论文
73 Overview of mimotopes and related strategies in tumor vaccine development. 期刊论文
74 Cellular prion protein promotes invasion and metastasis of gastric cancer. 期刊论文
75 Mechanisms of growth arrest by zinc ribbon domain-containing 1 (ZNRD1) in gastric cancer cells. 期刊论文
76 Expression of 15-PGDH is down-regulated by COX-2 in gastric cancer. 期刊论文
77 Hepatitis B in China. 期刊论文
78 ERK/MAPK activation involves in hypoxia-induced MGr1-Ag/37LRP expression and contributes to apoptosis resistance in gastric cancer. 期刊论文
79 ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2. 期刊论文
80 肿瘤研究前沿（第8卷） 专著
81 Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells. 期刊论文
82 Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo. 期刊论文
83 High frequency occurrence of 1-OPRD variant of PRNP gene in gastric cancer cell lines and Chinese population with gastric cancer. 期刊论文
84 Inhibitory effects of a specific phage-displayed peptide on high peritoneal metastasis of gastric cancer. 期刊论文
85 Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation. 期刊论文
86 p75 Neurotrophin Receptor Inhibits Invasion and Metastasis of Gastric Cancer. 期刊论文
87 Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: A novel cancer biomarker. 期刊论文
88 Expression, Purification, and Characterization of Recombinant Protein GX1-rmhTNFalpha. 期刊论文
89 Hypoxia induced HIF-1 accumulation and VEGF expression in gastric epithelial mucosa cell: involvement of ERK1/2 and PI3K/Akt. 期刊论文
90 Reversal of Multidrug Resistance of Adriamycin-resistant Gastric Adenocarcinoma Cells Through the Up-regulation of DARPP-32. 期刊论文
91 Expression and Clinical Significance of CacyBP/SIP in Pancreatic Cancer. 期刊论文
92 Expression of CacyBP/SIP Protein in Normal and Malignant Human Tissues: An Immunohistochemical Survey. 期刊论文
93 Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer. 期刊论文
94 Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS. 期刊论文
95 Expression and Prognostic Value of MG7-Ag in Patients With Surgically Resectable Esophageal Squamous Cell Carcinoma. 期刊论文
96 Reversal of Multidrug Resistance of Gastric Cancer Cells by Downregulation of Akt1 with Akt1 siRNA. 期刊论文
97 Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity. 期刊论文
98 Regulation of Multidrug Resistance by MGr1-Antigen in Gastric Cancer Cells. 期刊论文
99 Survivin, the Promising Target in Hepatocellular Carcinoma Gene Therapy. 期刊论文
100 Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. 期刊论文
101 Identification of GAS1 as an epirubicin resistance related gene in human gastric cancer cells with a partially randomized siRNA library. 期刊论文
102 Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer. 期刊论文
103 Expression and significance of TWIST basic helix-loop-helix protein overexpression in gastric cancer. 期刊论文
104 Preparation and Characterization of a Specific Monoclonal Antibody Against a New Gene Product: URG11. 期刊论文
105 Hepatitis B in China. 期刊论文
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