腺病毒CRISPR/Cas9系统介导在体修复OTOF突变 听神经病小鼠耳蜗带状突触功能的研究

81770997
2017
H1404.听觉异常与平衡障碍
柳柯
面上项目
教授
首都医科大学
51万元
听神经病;耳蜗带状突触;CRISPR/Cas9系统;人工耳蜗植入;OTOF突变
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 100dB SPL白噪声暴露对小鼠耳蜗听神经髓鞘的影响 期刊论文 郭晓安;柯朝阳;柳柯;魏薇;施磊
2 The c.824C>A and c.616dupA mutations in the SLC17a8 gene are associated with auditory neuropathy and lead to defective expression of VGluT3 期刊论文 Yue Qi;Shusheng Gong;Ke Liu;Yueshuai Song
3 Long-term exposure to low-intensity environmental noise aggravates age-related hearing loss via disruption of cochlear ribbon synapses 期刊论文 Feng Shuai;Yang Le;Hui Lian;Luo Yangtuo;Du Zhengde;Xiong Wei;Liu Ke;Jiang Xuejun
4 中-低强度噪声暴露对耳蜗带状突触的影响 期刊论文 王园园;孙毓晗;柳柯;孔婷婷
5 Repeated Moderate Sound Exposure Causes Accumulated Trauma to Cochlear Ribbon Synapses in Mice 期刊论文 Yangtuo Luo;Tengfei Qu;Qingling Song;Yue Qi;Shukui Yu;Shusheng Gong;Ke Liu;Xuejun Jiang
6 Autophagy is Required for Remodeling in Postnatal Developing Ribbon Synapses of Cochlear Inner Hair Cells 期刊论文 Wei Xiong;Wei Wei;Yue Qi;Zhengde Du;Tengfei Qu;Ke Liu;Shusheng Gong
7 RNA-seq profiling and co-expression network analysis of long noncoding RNAs and mRNAs reveal novel pathogenesis of noise-induced hidden hearing loss. 期刊论文 Wei Wei;Shi Xi;Xiong Wei;He Lu;Du Zheng-De;Qu Tengfei;Qi Yue;Gong Shu-Sheng;Liu Ke;Ma Xiulan
8 Dynamic Changes of Functional Neuronal Activities between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram. 期刊论文 Qu Tengfei;Qi Yue;Yu Shukui;Du Zhengde;Wei Wei;Cai Aoling;Wang Jie;Nie Binbin;Liu Ke;Gong Shusheng
9 Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea. 期刊论文 Yu Shu Kui;Du Zheng De;Song Qing Ling;Qu Teng Fei;Qi Yue;Xiong Wei;He Lu;Wei Wei;Gong Shu Sheng;Liu Ke
10 早期听觉衰老小鼠在110dB白噪声暴露下听力损害特征及机制研究 期刊论文 丁同慧;柳柯;阎艾慧
11 Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway 期刊论文 Wenqi Liang;Chunli Zhao;Zhongrui Chen;Zijing Yang;Ke Liu;Shusheng Gong
12 Loss of cochlear ribbon synapses in the early stage of aging causes initial hearing impairment. 期刊论文 Wei Xiong;Shukui Yu;Ke Liu;Shusheng Gong
13 Otof 1273(C>T)基因定点突变的耳聋小鼠模型的构建方法及其应用。 专利 柳柯;时晰
14 Long-term Conductive Auditory Deprivation During Early Development Causes Irreversible Hearing Impairment and Cochlear Synaptic Disruption. 期刊论文 Yue Qi;Shukui Yu;Zhengde Du;Tengfei Qu;Lu He;Wei Xiong;Wei Wei;Ke Liu;Shusheng Gong
15 Deletion of C1ql1 Causes Hearing Loss and Abnormal Auditory Nerve Fibers in the Mouse Cochlea 期刊论文 Yue Qi;Wei Xiong;Shukui Yu;Zhengde Du;Tengfei Qu;Lu He;Wei Wei;Lingjun Zhang;Ke Liu;Yi Li;David Z. He;Shusheng Gong
16 隐匿性听力损失和耳蜗带状突触病变——对听觉损害与保护的新考量 期刊论文 柳柯;龚树生
17 隐匿性听力损失的临床特征、诱发因素和致病机制 期刊论文 庞功采;孙毓晗;柳柯
18 Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold 期刊论文 Zhang Wei;Peng Zhe;Yu ShuKui;Song Qing-Ling;Qu Teng-Fei;He Lu;Liu Ke;Gong Shu-Sheng
19 Complete Elimination of Peripheral Auditory Input Before Onset of Hearing Causes Long-Lasting Impaired Social Memory in Mice 期刊论文 Rui Guo;Yang Li;Jiao Liu;Shusheng Gong;Ke Liu
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