膳食氧化固醇通过调节肠道微生态诱导的阿尔茨海默发生发展的作用及机制

81673149
2016
H3003.人类营养
肖荣
面上项目
教授
首都医科大学
60万元
肠道微生态;微小RNA;β淀粉样肽清除;阿尔茨海默病;氧化固醇
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 27-hydroxycholesterol promotes A beta accumulation via altering A beta metabolism in mild cognitive impairment patients and APP/PS1 mice 期刊论文 Zhang Xiaona;Xi Yuandi;Yu Huiyan;An Yu;Wang Ying;Tao Lingwei;Wang Yushan;Liu Wen;Wang Tao;Xiao Rong
2 Dietary Intake of Riboflavin and Unsaturated Fatty Acid Can Improve the Multi-Domain Cognitive Function in Middle-Aged and Elderly Populations: A 2-Year Prospective Cohort Study 期刊论文 Tao Lingwei;Liu Kuo;Chen Si;Yu Huiyan;An Yu;Wang Ying;Zhang Xiaona;Wang Yushan;Qin Zhongsheng;Xiao Rong
3 27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells 期刊论文 Chen Si;Zhou Cui;Yu Huiyan;Tao Lingwei;An Yu;Zhang Xiaona;Wang Ying;Wang Yushan;Xiao Rong
4 27-Hydroxycholesterol promotes the transfer of astrocyte-derived cholesterol to neurons in co-cultured SH-SY5Y cells and C6 cells 期刊论文 Yushan Wang;Xiaona Zhang;Tao Wang;Wen Liu;Lijing Wang;Ling Hao;Mengwei Ju;Rong Xiao
5 The Correlation between Early Stages of Life Exposed to Chinese Famine and Cognitive Decline in Adulthood: Nutrition of Adulthood Plays an Important Role in the Link? 期刊论文 Rong Hongguo;Xi Yuandi;An Yu;Tao Lingwei;Zhang Xiaona;Yu Huiyan;Wang Ying;Qin Zhongsheng;Xiao Rong
6 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells 期刊论文 An Yu;Zhang Dan-Di;Yu Huan-Ling;Ma Wei-Wei;Lu Yan-Hui;Liu Quan-Ri;Xiao Rong
7 27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction 期刊论文 Wang Ying;An Yu;Ma Weiwei;Yu Huiyan;Lu Yanhui;Zhang Xiaona;Wang Yushan;Liu Wen;Wang Tao;Xiao Rong
8 Dietary intakes and biomarker patterns of folate, vitamin B-6, and vitamin B-12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1 期刊论文 An Yu;Feng Lingli;Zhang Xiaona;Wang Ying;Wang Yushan;Tao Lingwei;Qin Zhongsheng;Xiao Rong
9 Increased Levels of 27-Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats 期刊论文 Zhang Xiaona;Lv Chenyan;An Yu;Liu Quanri;Rong Hongguo;Tao Lingwei;Wang Ying;Wang Yushan;Xiao Rong
10 Longitudinal and Nonlinear Relations of Dietary and Serum cholesterol in Midlife with Cognitive Decline: Results from EMCOA Study 期刊论文 Yu An;Xiaona Zhang;Ying Wang;Yushan Wang;Wen Liu;Tao Wang;Zhongsheng Qin;Rong Xiao
11 Patterns of cognitive function in middle-aged and elderly Chinese adults—findings from the EMCOA study 期刊论文 Yu An;Lingli Feng;Xiaona Zhang;Ying Wang;Yushan Wang;Lingwei Tao;Yanhui Lu;Zhongsheng Qin;Rong Xiao
12 27-Hydroxycholesterol Alters Synaptic Structural and Functional Plasticity in Hippocampal Neuronal Cultures 期刊论文 Wang Yushan;An Yu;Zhang Dandi;Yu Huiyan;Zhang Xiaona;Wang Ying;Tao Lingwei;Xiao Rong
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