基于嘌呤和嘧啶核心骨架的肿瘤靶向性MGMT抑制剂的设计、合成与生物活性评价

82003599
2020
H3401.合成药物化学
孙国辉
青年科学基金项目
副教授
北京工业大学
24万元
耐药性;抗癌烷化剂;肿瘤靶向性;O6-甲基鸟嘌呤-DNA甲基转移酶;抑制剂
2021-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The Dual Role of DNA Repair Protein MGMT in Cancer Prevention and Treatment 期刊论文 Peiying Bai;Tengjiao Fan;Guohui Sun;Xin Wang;Lijiao Zhao;Rugang Zhong
2 Modulating MGMT expression through interfering with cell signaling pathways 期刊论文 Peiying Bai;Tengjiao Fan;Xin Wang;Lijiao Zhao;Rugang Zhong;Guohui Sun
3 Chemometric QSAR modeling of acute oral toxicity of Polycyclic Aromatic Hydrocarbons (PAHs) to rat using simple 2D descriptors and interspecies toxicity modeling with mouse 期刊论文 Guohui Sun;Yifan Zhang;Luyu Pei;Yuqing Lou;Yao Mu;Jiayi Yun;Feifan Li;Yachen Wang;Zhaoqi Hao;Sha Xi;Chen Li;Chuhan Chen;Lijiao Zhao;Na Zhang;Rugang Zhong;Yongzhen Peng
4 Molecular Toxicology and Cancer Prevention 专著 Guohui Sun;Chongwen Wang
5 Quantitative Structure-Activity Relationship (QSAR) Studies on the Toxic Effects of Nitroaromatic Compounds (NACs): A Systematic Review 期刊论文 Tao Huang;Guohui Sun;Lijiao Zhao;Na Zhang;Rugang Zhong;Yongzhen Peng
6 Ecotoxicological QSAR modelling of the acute toxicity of fused and non-fused polycyclic aromatic hydrocarbons (FNFPAHs) against two aquatic organisms: Consensus modelling and comparison with ECOSAR 期刊论文 Feifan Li;Guohui Sun;Tengjiao Fan;Na Zhang;Lijiao Zhao;Rugang Zhong;Yongzhen Peng
7 Systematic QSAR and iQCCR modelling of fused/non-fused aromatic hydrocarbons (FNFAHs) carcinogenicity to rodents: reducing unnecessary chemical synthesis and animal testing 期刊论文 Feifan Li;Tengjiao Fan;Guohui Sun;Lijiao Zhao;Rugang Zhong;Yongzhen Peng
8 Molecular Toxicology and Cancer Prevention 期刊论文 Guohui Sun;Chongwen Wang
9 QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency 期刊论文 Guohui Sun;Peiying Bai;Tengjiao Fan;Lijiao Zhao;Rugang Zhong;R. Stanley McElhinney;T. Brian H. McMurry;Dorothy J. Donnelly;Joan E. McCormick;Jane Kelly;Geoffrey P. Margison
10 2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation 期刊论文 Xiaodong Sun;Tengjiao Fan;Guohui Sun;Yue Zhou;Yaxin Huang;Na Zhang;Lijiao Zhao;Rugang Zhong;Yongzhen Peng
11 一种基于2D 分子描述符的 PAHs 致癌性预测方法及预测模型 专利 孙国辉;李非凡;陈硕;赵丽娇;钟儒刚
12 Environmental toxicity risk evaluation of nitroaromatic compounds: Machine learning driven binary/multiple classification and design of safe alternatives 期刊论文 Yuxing Hao;Tengjiao Fan;Guohui Sun;Feifan Li;Na Zhang;Lijiao Zhao;Rugang Zhong
13 Ecotoxicological QSAR study of fused/non-fused polycyclic aromatic hydrocarbons (FNFPAHs): Assessment and priority ranking of the acute toxicity to Pimephales promelas by QSAR and consensus modeling methods 期刊论文 Shuo Chen;Guohui Sun;Tengjiao Fan;Feifan Li;Yuancong Xu;Na Zhang;Lijiao Zhao;Rugang Zhong
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