组蛋白H3K27甲基转移酶EZH2在顺铂致急慢性肾损伤中的作用和机制研究

81670623
2016
H0502.泌尿系统损伤与修复
庄守纲
面上项目
教授
同济大学
58万元
表观遗传调控;肾脏纤维化;急性肾损伤;EZH2;顺铂
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion 期刊论文 Chongxiang Xiong;Xiujuan Zang u;Xiaoxu Zhou;Lirong Liu;Monica V Masucci;Jinhua Tang;Xuezhu Li;Na Liu;George Bayliss;Ting C Zhao;Shougang Zhuang
2 Histone deacetylase 6 inhibition counteracts the epithelial-mesenchymal transition of peritoneal mesothelial cells and prevents peritoneal fibrosis 期刊论文 Liuqing Xu;Na Liu;Hongwei Gu;Hongrui Wang;Yingfeng Shi;Xiaoyan Ma;Shuchen Ma;Jun Ni;Min Tao;Andong Qiu;Shougang Zhuang
3 Targeting Src attenuates peritoneal fibrosis and inhibits the epithelial to mesenchymal transition 期刊论文 Jun Wang;Li Wang;Liuqing Xu;Yingfeng Shi;Feng Liu;Hualin Qi;Na Liu;Shougang Zhuang
4 慢性肾脏病 专著 庄守纲
5 Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-β and EGFR signaling pathways in obstructive nephropathy 期刊论文 Xingying Chen;Chao Yu;Xiying Hou;Jialu Li;Tingting Li;Andong Qiu;Na Liu;Shougang Zhuang
6 Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis 期刊论文 Chongxiang Xiong;Yingjie Guan;Xiaoxu Zhou;Lirong Liu;Michelle A Zhuang;Wei Zhang;Yunhe Zhang;Monica V Masucci;George Bayliss;Ting C Zhao;Shougang Zhuang
7 Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression 期刊论文 Chao Yu;Chongxiang Xiong;Jinhua Tang;Xiying Hou;Na Liu;George Bayliss;Shougang Zhuang
8 Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia 期刊论文 Yingfeng Shi;Liuqing Xu;Min Tao;Lu Fang;Jiasun Lu;Hongwei Gu;Shuchen Ma;Tao Lin;Yi Wang;Wenfang Bao;Andong Qiu;Shougang Zhuang;Na Liu
9 3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression 期刊论文 Jun Ni;Xiying Hou;Xueqiao Wang;Yinfeng Shi;Liuqing Xu;Xiaoqing Zheng;Na Liu 1;Andong Qiu;Shougang Zhuang
10 Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats 期刊论文 Na Liu;Liuqing Xu;Yingfeng Shi;Lu Fang;Hongwei Gu;Hongrui Wang;Xiaoqiang Ding;Shougang Zhuang
11 Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial-mesenchymal transition 期刊论文 Lirong Liu;Jianan Zou;Yingjie Guan;Yunhe Zhang;Wei Zhang;Xiaoxu Zhou;Chongxiang Xiong;Evelyn Tolbert;Ting C Zhao;George Bayliss;Shougang Zhuang
12 Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosi 期刊论文 Yunhe Zhang;Jianan Zou;Evelyn Tolbert;Ting C Zhao;George Bayliss;Shougang Zhuang
13 Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury 期刊论文 Wei Zhang;Yinjie Guan;George Bayliss;Shougang Zhuang
14 Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury 期刊论文 Jinhua Tang;Yingfeng Shi;Na Liu;Liuqing Xu;Xiujuan Zang;Peibin Li;Juanlian Zhang;Xiaoqing Zheng;Andong Qiu;Shougang Zhuang
15 Nintedanib, a triple tyrosine kinase inhibitor, attenuates renal fibrosis in chronic kidney disease 期刊论文 Feng Liu;Li Wang;Hualin Qi;Jun Wang;Yi Wang;Wei Jiang;Liuqing Xu;Na Liu;Shougang Zhuang
16 Delayed administration of suramin attenuates peritoneal fibrosis in rats 期刊论文 Chongxiang Xiong;Na Liu;Xiaofei Shao;Sairah Sharif;Hequn Zou x;Shougang Zhuang
17 Targeting enhancer of zeste homolog 2 protects against acute kidney injury 期刊论文 X Zhou;X ZangC;Y Guan;T Tolbert;T C Zhao;G Bayliss;S Zhuang
18 Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis 期刊论文 Xiaoxu Zhou;Chongxiang Xiong;Evelyn Tolbert;Ting C Zhao;George Bayliss;Shougang Zhuang
19 Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling 期刊论文 Yu Zhu;Chao Yu;Shougang Zhuang
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