ALA光动力联合PD-1/PD-L1抑制剂治疗皮肤鳞状细胞癌的效应与机制研究
81872212
2018
H1817.肿瘤物理治疗
王秀丽
面上项目
教授
同济大学
57万元
效应T细胞;抗肿瘤免疫;程序性死亡分子1/程序性死亡分子配体1（PD-1/PD-L1）;5-氨基酮戊酸光动力疗法（ALA-PDT）;皮肤鳞状细胞癌（SCC）
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 5-氨基酮戊酸光动力治疗中重度痤疮的技术创新与临床应用 | 奖励 | 王秀丽;鞠强;张玲琳;王宏伟;石磊;王佩茹;张国龙 |
| 2 | Transcriptomic analysis of mechanism of melanoma cell death induced by photothermal therapy | 期刊论文 | Guorong Yan;Lei Shi;Fuhe Zhang;Min Luo;Guolong Zhang;Pei Liu;Kaili Liu;Wei R Chen;Xiuli Wang |
| 3 | ALA-PDT successfully treated Majocchi’s granuloma by directly killing Trichophyton tonsurans and recruiting T lymphocytes | 期刊论文 | Lei Shi;Qianqian Wu;Jin Yang;Jingwen Tan;Hong Yang;Chan Hu;Yunfeng Zhang;Haiyan Zhang;Linglin Zhang;Yeqiang Liu;Lianjuan Yang;Xiuli Wang |
| 4 | Long-term improvement on photoaging after ALA photodynamic therapy for actinic keratosis: A retrospective study | 期刊论文 | Linglin Zhang;Zijun Zhao;Peiru Wang;Guolong Zhang;Bo Wang;Lei Shi;Xiaojing Liu;Zhongxia Zhou;Xiuli Wang |
| 5 | Differential Diagnosis and Precision Therapy of Two Typical Malignant Cutaneous Tumors Leveraging Their Tumor Microenvironment: A Photomedicine Strategy | 期刊论文 | Peiru Wang;Weitao Yang;Shuzhan Shen;Chao Wu;Long Wen;Qian Cheng;Bingbo Zhang;Xiuli Wang |
| 6 | Modified 5-aminolevulinic acid photodynamic therapy to reduce pain in the treatment of moderate to severe acne vulgaris: A prospective, randomized split-face study | 期刊论文 | Yunfeng Zhang;Haiyan Zhang;Linglin Zhang;Peiru Wang;Lei Shi;Guolong Zhang;Zhongxia Zhou;Stuart Marcus;Xiuli Wang |
| 7 | 皮肤恶性肿瘤5-氨基酮戊酸光动力诊疗与康复体系的创建与应用 | 奖励 | 王秀丽;方方;李智铭;张国龙;王宏伟;黄鹏;石磊;张玲琳;周忠霞;王佩茹;张海艳 |
| 8 | Efficacy of photodynamic therapy in actinic cheilitis: A systematic review | 期刊论文 | Yuling Yang;Shuzhan Shen;Peiru Wang;Xiuli Wang |
| 9 | The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy | 期刊论文 | Lude Zhu;Guolong Zhang;Peiru Wang;Linglin Zhang;Jie Ji;Xiaojing Liu;Zhongxia Zhou;Jingjun Zhao;Xiuli Wang |
| 10 | 奥马珠单抗在皮肤科的应用 | 期刊论文 | 杨雨桐;石磊;王秀丽 |
| 11 | 新型无痛光动力治疗皮肤病关键技术及转化——新型实时可控无痛光动力治疗智能系统 | 奖励 | 王秀丽 |
| 12 | CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages | 期刊论文 | Jie Ji;Peiru Wang;Qian Zhou;Lude Zhu;Haiyan Zhang;Yunfeng Zhang;Zhe Zheng;Anil Kumar Bhatta;Goulong Zhang;Xiuli Wang |
| 13 | A prospective study of adverse reactions of ALA-PDT for acne vulgaris | 期刊论文 | Lei Shi;Jiayi Yang;Linglin Zhang;Yunfeng Zhang;Guorong Yan;Haiyan Zhang;Xiaojing Liu;Jin Yang;Peiru Wang;Guolong Zhang;Zhongxia Zhou;Xiuli Wang |
| 14 | Loss of retinoic acid receptor-related receptor alpha (Roralpha) promotes the progression of UV-induced cSCC | 期刊论文 | Guolong Zhang;Guorong Yan;Zhiliang Fu;Yuhao Wu;Fei Wu;Zhe Zheng;Shan Fang;Ying Gao;Xunxia Bao;Yeqiang Liu;Xiuli Wang;Sibo Zhu |
| 15 | 光动力治疗老年性皮肤肿瘤应用及研究进展 | 期刊论文 | 张海艳;王佩茹;王秀丽 |
| 16 | Molecular characterization of gene expression changes in murine cutaneous squamous cell carcinoma after 5-aminolevulinic acid photodynamic therapy | 期刊论文 | Shan Fang;Yuhao Wu;Haiyan Zhang;Qingyu Zeng;Peiru Wang;Linglin Zhang;Guorong Yan;Guolong Zhang;Xiuli Wang |
| 17 | Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation | 期刊论文 | Pei Liu;Weitao Yang;Lei Shi;Haiyan Zhang;Yan Xu;Peiru Wang;Guolong Zhang;Wei R.Chen;Bingbo Zhang;Xiuli Wang |
| 18 | Optical coherence tomography-based non-invasive evaluation of premalignant lesions in SKH-1 mice | 期刊论文 | Chu Zhou;Haonan Zhang;Peiru Wang;Lei Shi;Long Wen;Qi Chen;Guolong Zhang;Cheng Wang;Xiuli Wang |
| 19 | 一种用于皮肤检测的单阵元光声谱信号获取系统及方法 | 专利 | 王秀丽;王佩茹;文龙;程茜 |
| 20 | ALA-PDT combined holmium laser therapy of postoperative recurrent extramammary paget’s disease | 期刊论文 | Chunxiao Li;Lehang Guo;Peiru Wang;Lei Shi;Xiaofei Sun;Chan Hu;Guolong Zhang;Linglin Zhang;Yunfeng Zhang;Xiuli Wang |
| 21 | 光动力治疗操作技术规范 | 专著 | 王洪武;高社干;胡韶山;李长岭;李黎波;王秀丽 |
| 22 | Adverse reactions of ALA-PDT for the treatment of cutaneous diseases: A retrospective study | 期刊论文 | Lei Shi;Jiayi Yang;Linglin Zhang;Yunfeng Zhang;Guorong Yan;Haiyan Zhang;Jin Yang;Peiru Wang;Guolong Zhang;Zhongxia Zhou;Xiuli Wang |
| 23 | PD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinoma | 期刊论文 | Qingyu Zeng;Jiayi Yang;Jie Ji;Peiru Wang;Linglin Zhang;Guorong Yan;Yuhao Wu;Qi Chen;Jia Liu;Guolong Zhang;Xiuli Wang |
| 24 | 5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8 | 期刊论文 | Linglin Zhang;Jiayi Yang;Xiaojing Liu;Detian Xu;Lei Shi;Jia Liu;Qingyu Zeng;Xiuli Wang |
| 25 | SKH-1小鼠皮肤鳞癌细胞系及其在移植性瘤模型制备中应用 | 专利 | 王秀丽;王宏伟;吉杰 |
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