hnRNPK介导染色质重塑调控软骨基质合成在软骨再生修复中的作用与机制研究
92068105
2020
H0604.骨、关节、软组织损伤与修复
苏培强
重大研究计划
教授
中山大学
79万元
骨关节炎;软骨基质;软骨修复;染色质重塑;核内不均一核糖核蛋白K
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling | 期刊论文 | Chengzhi Wu;Hengyu Liu;Dongmei Zhong;Xiaoming Yang;Zhiheng Liao;Yuyu Chen;Shun Zhang;Deying Su;Baolin Zhang;Chuan Li;Liru Tian;Caixia Xu;Peiqiang Su |
| 2 | Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF-κB Signaling Pathways | 期刊论文 | Zhiheng Liao;Deying Su;Hengyu Liu;David Y. B. Deng;Jinna Wu;Yuyu Chen;Weimin Guo;Shun Zhang;Zhuling Li;Xiaona Ke;Tingting Wang;Taifeng Zhou;Peiqiang Su |
| 3 | 一种椎间盘退变动物模型的构建方法及应用 | 专利 | 苏培强;周太峰;吴金娜;陈宇煜;廖智恒;刘恒宇;张舜 |
| 4 | Spatiotemporal characterization of human early intervertebral disc formation at single-cell resolution | 期刊论文 | Taifeng Zhou;Yu Chen;Zhiheng Liao;Long Zhang;Deying Su;Zhuling Li;Xiaoming Yang;Xiaona Ke;Hengyu Liu;Yuyu Chen;Ricong Weng;Huimin Shen;Caixia Xu;Yong Wan;Ren Xu;Peiqiang Su |
| 5 | T52 attenuates oncogenic STAT3 signaling and suppresses osteosarcoma | 期刊论文 | Liru Tian;Chuan Li;Limin Xiang;Jia Zeng;Shuqing Chen;Weimin Guo;Shulin Chen;Yihai Wang;Xiangjiu He;Peiqiang Su;Caixia Xu |
| 6 | Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis | 期刊论文 | Yuyu Chen;Jinna Wu;Shun Zhang;Wenjie Gao;Zhiheng Liao;Taifeng Zhou;Yongyong Li;Deying Su;Hengyu Liu;Xiaoming Yang;Peiqiang Su;Caixia Xu |
| 7 | Self-amplifying loop of NF-kB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration | 期刊论文 | Jinna Wu;Yuyu Chen;Zhiheng Liao;Hengyu Liu;Shun Zhang;Dongmei Zhong;Xianjian Qiu;Taiqiu Chen;Deying Su;Xiaona Ke;Yong Wan;Taifeng Zhou;Peiqiang Su |
| 8 | M13, an anthraquinone compound isolated from Morinda officinalis promotes the osteogenic differentiation of MSCs by targeting Wnt/β-catenin signaling | 期刊论文 | Chuan Li;Liru Tian;Yihai Wang;Huan Luo;Jia Zeng;Peiqiang Su;Shulin Chen;Zhiheng Liao;Weimin Guo;Xiangjiu He;Shuqing Chen;Caixia Xu |
| 9 | Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf | 期刊论文 | Yuyu Chen;Taifeng Zhou;Zhiheng Liao;Wenjie Gao;Jinna Wu;Shun Zhang;Yongyong Li;Hengyu Liu;Hang Zhou;Caixia Xu;Peiqiang Su |
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