配合物对生物酶及核酸的化学动态修饰及探测

91953117
2019
B0702.生物分子的化学生物学
毛宗万
重大研究计划
教授
中山大学
60万元
动态探测;核酸;金属酶;配合物;化学修饰
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Two Novel Fan-Shaped Trinuclear Pt(ii) Complexes Act as G-quadruplex Binders and Telomerase Inhibitors 期刊论文 C.-X. Xu;L.-Y. Liu;B. Lv;H.-Y. Zhao;Q. Cao;T. Zhai;Z.-W. Mao
2 A Polarity-Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis 期刊论文 K.-N. Wang;L.-Y. Liu;D. Mao;S. Xu;C.-P. Tan;Q. Cao;Z.-W. Mao;B. Liu
3 CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors 期刊论文 Q. Cao;D.-J. Zhou;Z.-Y. Pan;G.-G. Yang;H. Zhang;L.-N. Ji;Z.-W. Mao
4 Anion-Responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death 期刊论文 F.-X. Wang;J.-W. Liu;X.-Q. Hong;C.-P. Tan;L. Zhang;W.-H. Chen;P. Sadler;Z.-W. Mao
5 Light-Driven Cascade Mitochondria-to-Nucleus Photosensitization in Cancer Cell Ablation 期刊论文 K.-N. Wang;L.-Y. Liu;G. Qi;X.-J. Chao;W. Ma;Z. Yu;Q. Pan;Z.-W. Mao;B. Liu
6 Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes 期刊论文 L.-Y. Liu;T.-Z. Ma;Y.-L. Zeng;W. Liu;Z.-W. Mao
7 Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol 期刊论文 X. Tao;L. Zhang;L. Du;K. Lu;Z. Zhao;Y. Xie;X. Li;S. Huang;P.-H. Wang;J.-A. Pan;W. Xia;J. Dai;Z.-W. Mao
8 What blocks more anticancer platinum complexes from experiment to Clinic: Major Problems and Potential Strategies from Drug Design Perspectives 期刊论文 K. Peng;B.-B. Liang;W. Liu;Z.-W. Mao
9 Regulation of DNA-Binding Activity of the Staphylococcus Aureus Catabolite Control Protein A by Copper (II)-Mediated Oxidation 期刊论文 X. Liao;H. Li;Y. Guo;F. Yang;Y. Chen;X. He;H. Li;W. Xia;Z.-W. Mao;H. Sun
10 Multiple-Color Platinum Complex with Super-Large Stokes Shift for Super-Resolution Imaging of Autolysosome Escape 期刊论文 L.-Y. Liu;H. Fang;Q. Chen;M. H.-Y. Chan;M. Ng;K.-N. Wang;W. Liu;Z. Tian;J. Diao;Z.-W. Mao;V. W.-W. Yam
11 Real-Time Tracking of ER Turnover during ERLAD by a Rhenium Complex via Lifetime Imaging 期刊论文 L. Hao;Y.-Y. Ling;Z.-X. Huang;Z.-Y. Pan;C.-P. Tan;Z.-W. Mao
12 An Enhanced Photothermal Therapeutic Iridium Hybrid Platform Reversing the Tumor Hypoxic Microenvironment 期刊论文 H. Zhang;X. Chen;S. Li;J. Shen;Z.-W. Mao
13 Selectivity and Targeting of G-quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics 期刊论文 B.-C. Zhu;J. He;W. Liu;X.-Y. Xia;L.-Y. Liu;B.-B. Liang;H.-G. Yao;B. Liu;L.-N. Ji;Z.-W. Mao
14 Precisely Assembled Nanoparticles against Cisplatin Resistance via Cancer-Specific Targeting of Mitochondria and Imaging-Guided Chemo-Photothermal Therapy 期刊论文 G.-G. Yang;Z.-Y. Pan;D.-Y. Zhang;Q. Cao;L.-N. Ji;Z.-W. Mao
15 Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes 期刊论文 Z.-Y. Pan;C.-P. Tan;L.-S. Rao;H. Zhang;Y. Zheng;L. Hao;L.-N. Ji;Z.-W. Mao
16 G-quadruplex Structural Transition Driven by a Platinum Compound 期刊论文 W. Liu;B.-C. Zhu;L.-Y. Liu;X.-Y. Xia;Z.-W. Mao
17 Light-Triggered Nitric Oxide Release Photosensitizer to Combat Bacterial Biofilm Infections 期刊论文 Z. Zhao;H. Li;X. Tao;Y. Xie;L. Yang;Z.-W. Mao;W. Xia
18 A Continuous Add-On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis 期刊论文 K.-N. Wang;X. Shao;Z. Tian;L.-Y. Liu;C. Zhang;C.-P. Tan;J. Zhang;P. Ling;F. Liu;Q. Chen;J. Diao;Z.-W. Mao
19 Self-Amplifying Iridium(III) Photosensitizer for Ferroptosis-Mediated Immunotherapy Against Transferrin Receptor-Overexpressing Cancer 期刊论文 Y.-Y. Ling;W.-J. Wang;L. Hao;X.-W. Wu;J.-H. Liang;H. Zhang;Z.-W. Mao;C.-P. Tan
20 Simultaneous Photoactivation of cGAS-STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy 期刊论文 Y.-Y. Ling;X.-Y. Xia;L. Hao;W.-J. Wang;H. Zhang;L.-Y. Liu;W. Liu;Z.-Y. Li;C.-P. Tan;Z.-W. Mao
21 Approaches Towards Understanding the Mechanism-of-Action of Metallodrugs 期刊论文 X.-L. Xiong;L.-Y. Liu;Z.-W. Mao;T.-T. Zou
22 Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid 期刊论文 L.-Y. Liu;K.-N. Wang;W. Liu;Y.-L. Zeng;M.-X. Hou;J. Yang;Z.-W. Mao
23 In Situ Prodrug Activation by an Affibody–Ruthenium Catalyst Hybrid for HER2-Targeted Chemotherapy 期刊论文 Z. Zhao;X. Tao;Y. Xie;Q. Lai;W. Lin;K. Lu;J. Wang;W. Xia;Z.-W. Mao
24 The Design of Cyclometalated Iridium(III)-Metformin Complexes for Hypoxic Cancer Treatment 期刊论文 J. Yang;H.-J. Fang;Q. Cao;Z.-W. Mao
25 A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity 期刊论文 X. Su;W.-J. Wang;Q. Cao;H. Zhang;B. Liu;Y. Ling;X. Zhou;Z.-W. Mao
26 Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex 期刊论文 W.-J. Wang;M. Xia;C.-P. Tan;Y.-J. Wang;Y.-B. Zhang;G.-H. Li;Z.-W. Mao
27 Pt(IV)-Deferasirox Prodrug Combats DNA Damage Repair by Regulating RNA N-6-Methyladenosine Methylation 期刊论文 Z.-Y. Pan;Y.-Y. Ling;H. Zhang;L. Hao;C.-P. Tan;Z.-W. Mao
28 A Platinum–Ruthenium Hybrid Prodrug with Multi-Enzymatic Activities for Chemo-Catalytic Therapy of Hypoxic Tumors 期刊论文 G.-G. Yang;X.-X. Su;B.-B. Liang;Z.-Y. Pan;Q. Cao;Z.-W. Mao
29 Inhibition of Quorum-Sensing Regulator from Pseudomonas aeruginosa Using a Flavone Derivative 期刊论文 Y. Xie;J. Chen;B. Wang;A.-Y. Peng;Z.-W. Mao;W. Xia
30 3D CoPt Nanostructures Hybridized with Iridium Complexes for Multimodal Imaging and Combined Photothermal-Chemotherapy 期刊论文 H. Zhang;D.-Y. Zhang;J. Shen;Z.-W. Mao
31 Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination 期刊论文 L.-Y. Liu;W. Liu;K.-N. Wang;B.-C. Zhu;X.-Y. Xia;L.-N. Ji;Z.-W. Mao
32 Probing Cell Membrane Damage Using Molecular Rotor Probe with Membrane-to-Nucleus Translocation 期刊论文 K.-N. Wang;G. Qi;H. Chu;X.-J. Chao;L.-Y. Liu;G. Li;Q. Cao;Z.-W. Mao;B. Liu
33 Solution Structure of a Thrombin Binding Aptamer Complex with a Non-Planar Platinum(II) Compound 期刊论文 B.-C. Zhu;J. He;X.-Y. Xia;J. Jiang;W. Liu;L.-Y. Liu;B.-B. Liang;H.-G. Yao;Z. Ke;W. Xia;Z.-W. Mao
34 Ferroptosis-Enhanced Cancer Immunity by a Ferrocene-Appended Iridium(III) Diphosphine Complex 期刊论文 W.-J. Wang;Y.-Y. Ling;Y.-M. Zhong;Z.-Y. Li;C.-P. Tan;Z.-W. Mao
35 Mitochondria-Targeting Monofunctional Platinum(ii)-Lonidamine Conjugates for Cancer Cell De-energization 期刊论文 N. Muhammad;C.-P. Tan;K. Muhammad;J. Wang;N. Sadia;Z.-Y. Pan;L.-N. Ji;Z.-W. Mao
36 Regulating Tumor N6-Methyladenosine Methylation Landscape using Hypoxia-Modulating OsSx Nanoparticles 期刊论文 Y. Zheng;Y. Ling;D.-Y. Zhang;C.-P. Tan;H. Zhang;G.-G. Yang;H. Wang;L.-N. Ji;Z.-W. Mao
37 Allosteric Inhibition of SARS-CoV-2 3CL Protease by Colloidal Bismuth Subcitrate 期刊论文 X. Tao;L. Zhang;L. Du;R. Liao;H. Cai;K. Lu;Z. Zhao;Y. Xie;P.-H. Wang;J.-A. Pan;Y. Zhang;G. Li;J. Dai;Z.-W. Mao;W. Xia
38 A Nuclear-Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation 期刊论文 K.-N. Wang;L.-Y. Liu;D. Mao;M.-X. Hou;C.-P. Tan;Z.-W. Mao;B. Liu
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