三级淋巴样结构中的ICOSL+B细胞亚群启动抗肿瘤免疫的机制研究
91942309
2019
H1102.免疫应答异常
苏士成
重大研究计划
主任医师
中山大学
250万元
三级淋巴样结构;抗肿瘤免疫;免疫源性细胞死亡;乳腺肿瘤;B细胞亚群
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Eosinophil extracellular traps drive asthma progression through neuro-immune signals | 期刊论文 | Yiwen Lu;Yijiao Huang;Jiang Li;Jingying Huang;Lizhi Zhang;Jingwei Feng;Jiaqian Li;Qidong Xia;Qiyi Zhao;Linjie Huang;Shanping Jiang;Shicheng Su |
| 2 | Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output | 期刊论文 | Qiyi Zhao;Jiayu Liu;Hong Deng;Ruiying Ma;Jian-You Liao;Huixin Liang;Jingxiong Hu;Jiaqian Li;Zhiyong Guo;Junchao Cai;Xiao-Ding Xu;Gao Zhiliang;Shicheng Su |
| 3 | 霍英东教育基金第十七届高等院校青年教师奖 | 奖励 | 苏士成 |
| 4 | Mitochondria-specific delivery system for targeted regulation of mitochondrial gene expression | 期刊论文 | Shicheng Su;Shuwen Cao;Jiayu Liu;Xiaoding Xu |
| 5 | CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition | 期刊论文 | Xinwei Liu;Yiwen Lu;Jingying Huang;Yue Xing;Huiqi Dai;Liling Zhu;Shunrong Li;Jingwei Feng;Boxuan Zhou;Jiaqian Li;Qidong Xia;Jiang Li;Min Huang;Yuanting Gu;Shicheng Su |
| 6 | B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis | 期刊论文 | Zeng Qiuhui;Wei Yuan;Lao Xiangming;Chen Dongping;Huang Chunxiang;Lin Qiangyi;He Min;Liao Yuan;Zheng Limin;Li Bao;Zhang Guangbo;Chen Yun;Kuang Dongming |
| 7 | CD16+成纤维细胞在诊断、预防和治疗单克隆抗体耐药乳腺癌中的应用 | 专利 | 苏士成;陆艺文 |
| 8 | CCDC25在预测乳腺癌预后、抑制乳腺癌远处器官转移中的应用 | 专利 | 宋尔卫;苏士成;杨林槟;陈嘉宁;张晓倩;李嘉倩;李和亮 |
| 9 | 科学探索奖 | 奖励 | 苏士成 |
| 10 | Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination | 期刊论文 | Yiming Tu;Zhenyao Chen;Pengzhan Zhao;Guangchi Sun;Zhongyuan Bao;Honglu Chao;Liang Fan;Chong Li;Yongping You;Yan Qu;Yun Chen;Jing Ji |
| 11 | A CD10‐OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1 | 期刊论文 | Shubin Yu;Yiwen Lu;An Su;Jianing Chen;Jiang Li;Boxuan Zhou;Xinwei Liu;Qidong Xia;Yihong Li;Jiaqian Li;Min Huang;Yingying Ye;Qiyi Zhao;Sushi Jiang;Xiaoqing Yan;Xiaojuan Wang;Can Di;Jiayao Pan;Shicheng Su |
| 12 | VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis | 期刊论文 | Jiaqian Li;Di Huang;Bingxi Lei;Jingying Huang;Linbing Yang;Man Nie;Shicheng Su;Qiyi Zhao;Ying Wang |
| 13 | 乳腺癌新辅助化疗耐药标志物及其应用 | 专利 | 苏士成;赵绮毅;黎江 |
| 14 | 中国细胞生物学学会青年科学家奖 | 奖励 | 苏士成 |
| 15 | Mitochondrial noncoding RNAs: new wine in an old bottle | 期刊论文 | Huixin Liang;Jiayu Liu;Shicheng Su;Qiyi Zhao |
| 16 | 一种雌激素受体阳性的小鼠乳腺癌细胞株的制备方法 | 专利 | 苏士成;李嘉倩 |
| 17 | 血清MPO-DNA在预测乳腺癌预后抑制乳腺癌远处器官转移中的应用 | 专利 | 宋尔卫;苏士成;杨林槟;陈嘉宁;张晓倩;李嘉倩;李和亮 |
| 18 | Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma | 期刊论文 | Boyuan Liu;Zewei Zhou;Yu Jin;Jinying Lu;Dongju Feng;Rui Peng;Hua Sun;Xiaoxin Mu;Changxian Li;Yun Chen |
| 19 | 首届钟南山青年科技创新奖 | 奖励 | 苏士成 |
| 20 | Tumor-associated macrophages promote PD-L1 expression in tumor cells by regulating PKM2 nuclear translocation in pancreatic ductal adenocarcinoma | 期刊论文 | Qing Xia;Jing Jia;Chupeng Hu;Jinying Lu;Jiajin Li;Haiyan Xu;Jianchen Fang;Dongju Feng;Liwei Wang;Yun Chen |
| 21 | Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma | 期刊论文 | Yao Yao;Zhongyi Yan;Senlin Lian;Liangnian Wei;Chao Zhou;Dongju Feng;Yuan Zhang;Jianrong Yang;Ming Li;Yun Chen |
| 22 | Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition | 期刊论文 | Jiang Li;Yingying Ye;Zhihan Liu;Guoyang Zhang;Huiqi Dai;Jiaqian Li;Boxuan Zhou;Yihong Li;Qiyi Zhao;Jingying Huang;Jingwei Feng;Shu Liu;Peigang Ruan;Jinjing Wang;Jiang Liu;Min Huang;Xinwei Liu;Shubin Yu;Ziyang Liang;Liping Ma;Xiaoxia Gou;Guoliang Zhang;Nian Chen;Yiwen Lu;Can Di;Qidong Xia;Jiayao Pan;Ru Feng;Qingqing Cai;Shicheng Su |
| 23 | 中源协和生命医学创新突破奖 | 奖励 | 苏士成 |
| 24 | The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer | 期刊论文 | Jiang Liu;Liyan Lao;Jianing Chen;Jiang Li;Wenfeng Zeng;Xiaofeng Zhu;Jiaqian Li;Xueman Chen;Linbin Yang;Yue Xing;Fei Chen;Di Huang;Xiaoqian Zhang;Wei Wei;Chang Gong;Shuya Huang;Zhigang Yu;Zhihua Li;Linhan Yang;Jinping Liu;Xiaozhen Liu;Qinghui Zheng;Xuli Meng;Jing Liang;Luyang Sun;Musheng Zeng;Mengfeng Li;Qiang Liu;Shicheng Su;Erwei Song |
| 25 | Targeting Regulator of G-protein Signaling 1 in Tumor-specific T cells Enhances Their Trafficking to Breast Cancer | 期刊论文 | Di Huang;Xueman Chen;Xin Zeng;Liyan Lao;Jiaqian Li;Yue Xing;Yiwen Lu;Qian Ouyang;Jianing Chen;Linbin Yang;Fengxi Su;Herui Yao;Qiang Liu;Shicheng Su;Erwei Song |
| 26 | Protocol for Single-Cell Analysis of Tumor-Infiltrating B Cells Isolated from Human Breast Cancer Tissue Before and After Neo-adjuvant Chemotherapy | 期刊论文 | Yiwen Lu;Jian-You Liao;Shicheng Su |
| 27 | 十大医学创新专家 | 奖励 | 苏士成 |
| 28 | PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma | 期刊论文 | Li-Gong Lu;Zhi-Ling Zhou;Xu-Yan Wang;Bo-Yuan Liu;Jin-Ying Lu;Shuai Liu;Guang-Bo Zhang;Mei-Xiao Zhan;Yun Chen |
| 29 | Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation | 期刊论文 | Jiang Li;Qidong Xia;Can Di;Chunni Li;Hang Si;Boxuan Zhou;Shubin Yu;Yihong Li;Jingying Huang;Yiwen Lu;Min Huang;Huixin Liang;Xinwei Liu;Qiyi Zhao |
| 30 | DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25 | 期刊论文 | Linbin Yang;Qiang Liu;Xiaoqian Zhang;Xinwei Liu;Boxuan Zhou;Jianing Chen;Di Huang;Jiaqian Li;Heliang Li;Fei Chen;Jiang Liu;Yue Xing;Xueman Chen;Shicheng Su;Erwei Song |
| 31 | Gastric Microbiome Alterations Are Associated with Decreased CD8+ Tissue-resident Memory T Cells in the Tumor Microenvironment of Gastric Cancer. | 期刊论文 | Rui Peng;Shuai Liu;Wenhua You;Yedi Huang;Chupeng Hu;Ye Gao;Xuemei Jia;Gang Li;Zekuan Xu;Yun Chen |
| 32 | Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity | 期刊论文 | Yiwen Lu;Qiyi Zhao;Jian-You Liao;Erwei Song;Qidong Xia;Jiayao Pan;Yihong Li;Jiaqian Li;Boxuan Zhou;Yingying Ye;Can Di;Shubin Yu;Yunjie Zeng;Shicheng Su |
| 33 | 一种肿瘤干细胞标记物的基因突变体、编码蛋白和应用 | 专利 | 苏士成;赵绮毅;黎江 |
| 34 | 靶向线粒体负载circRNA的纳米材料及其制备方法和应用 | 专利 | 苏士成;许小丁;刘嘉煜 |
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