慢性乙型肝炎组织微环境中巨噬细胞新亚群鉴定、发育来源及功能研究
91842309
2018
H2108.人乳头瘤病毒、狂犬病毒、细小病毒、朊病毒及其它病毒与感染
袁正宏
重大研究计划
研究员
复旦大学
282万元
巨噬细胞;乙型肝炎病毒;单细胞测序;原位杂交;肝脏微环境
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Functional Comparison of IFN‐α Subtypes Reveals Potent HBV Suppression by a Concerted Action of IFN‐α and ‐γ Signaling | 期刊论文 | Jieliang Chen;Yaming Li;Fritz Lai;Yang Wang;Kathrin Sutter;Ulf Dittmer;Jianyu Ye;Wenjing Zai;Min Liu;Fang Shen;Min Wu;Kongying Hu;Baocun Li;Mengji Lu;Xiaonan Zhang;Jiming Zhang;Jianhua Li;Qingfeng Chen;Zhenghong Yuan |
| 2 | Illuminating the Live-Cell Dynamics of Hepatitis B Virus covalent closed circular DNA using CRISPR-Tag | 期刊论文 | Jiahui Ding;Zhigang Yi;Wenjing Zai;Min Wu;Baohui Chen;Qiliang Cai;Xiaonan Zhang;Zhenghong Yuan |
| 3 | A streamlined clinical metagenomic sequencing protocol for rapid pathogen identification | 期刊论文 | Jia Xiaofang;Hu Lvyin;Wu Min;Ling Yun;Wang Wei;Lu Hongzhou;Yuan Zhenghong;Yi Zhigang;Zhang Xiaonan |
| 4 | Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes | 期刊论文 | Lei Yue;Chang Li;Mingzhu Xu;Min Wu;Jiahui Ding;Jiangxia Liu;Xiaonan Zhang;Zhenghong Yuan |
| 5 | Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV | 期刊论文 | Zhong Fang;Yi Zhang;Zhaoqin Zhu;Cong Wang;Yao Hu;Xiuhua Peng;Dandan Zhang;Jun Zhao;Bisheng Shi;Zhongliang Shen;Min Wu;Chunhua Xu;Jieliang Chen;Xiaohui Zhou;Youhua Xie;Hui Yu;Xiaonan Zhang;Jianhua Li;Yunwen Hu;Maya Kozlowski;Antonio Bertoletti;Zhenghong Yuan |
| 6 | Hepatitis B Virus cccDNA Minichromosomes in Distinct Epigenetic Transcriptional States Differ in Their Vulnerability to Damage | 期刊论文 | Yang Wang;Yumeng Li;Wenjing Zai;Kongying Hu;Yuanfei Zhu;Qiang Deng;Min Wu;Yaming Li;Jieliang Chen;Zhenghong Yuan |
| 7 | A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia | 期刊论文 | Min Wu;Cong Wang;Zhenghong Yuan;Zhong Fang;Boyin Qin;Xiaohui Zhou;Xiaonan Zhang;Zhenghong Yuan |
| 8 | HBV induced the discharge of intrinsic antiviral miRNAs in HBV-replicating hepatocytes via extracellular vesicles to facilitate its replication | 期刊论文 | Qiaofang Chu;Jianhua Li;Jieliang Chen;Zhenghong Yuan |
| 9 | Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy | 期刊论文 | Wenjing Zai;Kongying Hu;Jianyu Ye;Jiahui Ding;Cheng Huang;Yaming Li;Zhong Fang;Min Wu;Cong Wang;Jieliang Chen;Zhenghong Yuan |
| 10 | Serum ERK1/2 proteins fluctuating with HBV infection report frequency of viral-specific CD8 + T cells and predict IFNα therapeutic effect in chronic hepatitis B patients | 期刊论文 | Fang Zhong;Yu Xiaoyu;Tong Shuangmei;Lu Chuan;Huang Yuxian;Chen Liang;Yuan Zhenghong;Zhang Yi |
| 11 | The role of hepatitis B virus surface proteins in regulating the maturation and secretion of complete and incomplete virions | 期刊论文 | Mingzhu Xu;Chang Li;Jiahui Ding;Min Wu;Yijie Tang;Zhenghong Yuan;Xiaonan Zhang |
| 12 | 人α干扰素受体结合相关位点突变体及其用途 | 专利 | 袁正宏;陈捷亮;李亚明 |
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