阿尔茨海默病硫胺素代谢障碍损害认知功能相关的神经环路机制
91332201
2013
H0902.意识障碍与认知功能障碍
钟春玖
重大研究计划
教授
复旦大学
300万元
硫胺素代谢;阿尔茨海默病;神经环路;葡萄糖代谢;硫胺素焦磷酸激酶
2014-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease | 期刊论文 | Xiaoli Pan;Zhichun Chen;Guoqiang Fei;Shumei Pan;Weiqi Bao;Shuhua Ren;Yihui Guan;Chunjiu Zhong |
| 2 | Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata | 期刊论文 | Liu Huimin;Sang Shaoming;Lu Yuan;Wang Zhongfeng;Yu Xiang;Zhong Chunjiu |
| 3 | 放射性同位素氟-18代硫胺素、合成方法及应用 | 专利 | 钟春玖;王昌鹏 |
| 4 | Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease | 期刊论文 | Pan Xiaoli;Sang Shaoming;Fei Guoqiang;Jin Lirong;Liu Huimin;Wang Zhiliang;Wang Hui;Zhong Chunjiu |
| 5 | Oxidative stress in Alzheimer's disease | 期刊论文 | Chen Zhichun;Zhong Chunjiu |
| 6 | Environmental factors in the development and progression of late-onset Alzheimer's disease | 期刊论文 | Wainaina Moses N.;Chen Zhichun;Zhong Chunjiu |
| 7 | Iron Deposition Leads to Neuronal alpha-Synuclein Pathology by Inducing Autophagy Dysfunction | 期刊论文 | Wan Wenbin;Jin Lirong;Wang Zigao;Wang Lingyan;Fei Guoqiang;Ye Fanlong;Pan Xiaoli;Wang Changpeng;Zhong Chunjiu |
| 8 | Membrane Aging as the Real Culprit of Alzheimer's Disease: Modification of a Hypothesis | 期刊论文 | Qiujian Yu;Chunjiu Zhong |
| 9 | Iron Deposition Leads to Neuronal alpha-Synuclein Pathology by Inducing Autophagy Dysfunction | 期刊论文 | Wan Wenbin;Jin Lirong;Wang Zigao;Wang Lingyan;Fei Guoqiang;Ye Fanlong;Pan Xiaoli;Wang Changpeng;Zhong Chunjiu |
| 10 | Correlat ion of thiamine metabolite levels with cognitive function in the non-demented elderly | 期刊论文 | Lu Jingwen;Pan Xiaoli;Fei Guoqiang;Wang Changpeng;Zhao Lei;Sang Shaoming;Liu Huimin;Liu Meng;Wang Hui;Wang Zhiliang;Zhong Chunjiu |
| 11 | Insulin-like growth factor-1 protects SH-SY5Y cells against beta-amyloid-induced apoptosis via the PI3K/Akt-Nrf2 pathway | 期刊论文 | Wang Zigao;Xiong Lu;Wang Guanqun;Wan Wenbin;Zhong Chunjiu;Zu Hengbing |
| 12 | Environmental factors in the development and progression of late-onset Alzheimer's disease | 期刊论文 | Wainaina Moses N.;Chen Zhichun;Zhong Chunjiu |
| 13 | Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, while amyloid deposition does not | 期刊论文 | Shaoming Sang;Xiaoli Pan;Chichun Chen;Fan Zeng;Shumei Pan;Huimin Liu;Lirong JIn;Guoqiang Fei;Changpeng Wang;Shuhua Ren;Fangyang Jiao;WEiqi Bao;Weiyan Zhou;Yihui Guan;YIqiu Zhang;Hongcheng Shi;Yanjiang Wang;Xiang Yu;Yun Wang;Chunjiu Zhong |
| 14 | 骨形成蛋白-9作为制备治疗和/或预防与胆碱能系统退变相关疾病的药物组合物的用途 | 专利 | 钟春玖;王子高 |
| 15 | Oxidative stress in Alzheimer's disease | 期刊论文 | Chen Zhichun;Zhong Chunjiu |
| 16 | Correlat ion of thiamine metabolite levels with cognitive function in the non-demented elderly | 期刊论文 | Lu Jingwen;Pan Xiaoli;Fei Guoqiang;Wang Changpeng;Zhao Lei;Sang Shaoming;Liu Huimin;Liu Meng;Wang Hui;Wang Zhiliang;Zhong Chunjiu |
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